Results 51 to 60 of about 17,273 (262)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Local “Battlegrounds”. Relocating Multi-Level and Multi-Actor Governance of Immigration
Revue Européenne des Migrations Internationales, 2021 The multi-level governance (MLG) approach is widely used to understand the complex processes of immigration policymaking. In this literature review, we consider both (i) the vertical dimension of MLG: the local, regional, national, European, or even ...
Iraklis Dimitriadis +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
HeliyonThe European energy system is undergoing a drastic change, focusing on reducing natural gas consumption and import. European households, which are responsible for 25 % of final energy consumption, mainly based on natural gas, could play a significant ...
Javanshir Fouladvand +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Land, 2020 The loss of ecosystem services through land degradation continues to be a significant concern for policymakers and land users around the world. Facilitating collective action among various actors is regarded as imperative in halting land degradation ...
Menelisi Falayi +2 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Cooperative Multi-Agent Reinforcement Learning With Approximate Model Learning
IEEE Access, 2020 In multi-agent reinforcement learning, it is essential for agents to learn communication protocol to optimize collaboration policies and to solve unstable learning problems.
Young Joon Park +2 more
doaj +1 more source