Advanced Science, EarlyView.In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng +17 more
wiley +1 more source
Attention-based multi-agent reinforcement learning for traffic flow stability in mountainous tunnel entrances. [PDF]
Sci RepDuan M.
europepmc +1 more source
Massively Multiplexed Photonic Chip With Cross‐Channel Fusion For Harmonized Biosensing
Advanced Science, EarlyView.We introduce a transformative sensing platform integrating photonic multiplexing with over 10 000 sensors and a deep‐learning framework that combines domain adaptation and cross‐channel fusion for harmonized operation across heterogeneous chips. The platform achieves 99.3% identification accuracy and relative prediction errors of 10−4$^{-4}$ for ...
Ivan Saetchnikov +3 more
wiley +1 more source
A multi-agent reinforcement learning scheduling algorithm integrating state graph and task graph structural modeling for ride-sharing dispatching. [PDF]
Sci RepSha J, Song M, Sui G, Sun H, Dong D.
europepmc +1 more source
Advanced Science, EarlyView.By integrating knowledge‐augmented artificial intelligence with an oxygen‐supplemented 3D screening platform, a synergistic interaction between berberine and enzalutamide is identified. The framework integrates compound mechanisms of action with disease‐relevant signaling context to prioritize candidate combinations and generate testable pathway‐based ...
Chih‐Hui Lo +15 more
wiley +1 more source
A Novel Data-Driven Multi-Agent Reinforcement Learning Approach for Voltage Control Under Weak Grid Support. [PDF]
Sensors (Basel)Wu J +9 more
europepmc +1 more source
Terahertz Channel Modeling, Estimation and Localization in RIS‐Assisted Systems
Advanced Electronic Materials, EarlyView.Reconfigurable intelligent surfaces have become a recent intensive research focus. Based on practical applications, channel strategies for RIS‐assisted terahertz wireless communication systems are categorized into three different types: channel modeling, channel estimation, and channel localization.
Hongjing Wang +9 more
wiley +1 more source
Maynard Smith revisited: A multi-agent reinforcement learning approach to the coevolution of signalling behaviour. [PDF]
PLoS Comput BiolMacmillan-Scott O, Musolesi M.
europepmc +1 more source
From Materials to Systems: Challenges and Solutions for Fast‐Charge/Discharge Na‐Ion Batteries
Advanced Energy Materials, EarlyView.This review systematically analyzes the key characteristics limiting the fast‐charge/discharge capability of Na‐ion batteries (SIBs) from a multi‐scale perspective encompassing electrode materials, the electrode‐electrolyte interface, and the system. Furthermore, it presents practical solution strategies for the fundamental issues arising at each scale,
Bonyoung Ku +5 more
wiley +1 more source