Results 61 to 70 of about 37,321 (258)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A Hesitation-Associated Multi-Attribute Decision-Making Method Based on Generalized Interval-Valued Hesitation Fuzzy Weighted Heronian Averaging Operator

Mathematics
In multi-attribute decision making (MADM), complex situations often arise where decision attributes are interval-valued hesitant fuzzy numbers (IVHFNs) and the attributes are interrelated.
Jiayou Shen, Nan Yang, Hejun Liang
doaj   +1 more source

Optimal Multi-Attribute Decision Making in Social Choice Problems [PDF]

Proceedings of the Twenty-Seventh International Joint Conference on Artificial Intelligence, 2018
My thesis solves problems of decision making when alternatives are characterized by multiple attributes, under natural restrictions on agents’ preferences that are motivated by practical and cognitive considerations.  Computing optimal decisions in these settings is often hard in general.
openaire   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A Fuzzy Approach for Ranking Discrete Multi-Attribute Alternatives under Uncertainty

Mathematics, 2020
This paper presents a fuzzy approach for ranking discrete alternatives in multi-attribute decision-making under uncertainty. Linguistic variables approximated by fuzzy numbers were applied for facilitating the making of pairwise comparison by the ...
Lihui Liu, Hepu Deng
doaj   +1 more source

Multi-Attribute Decision-Making Model by Applying Grey Numbers

Informatica, 2009
Multi-attribute analysis is a useful tool in many economical, managerial, constructional, etc. problems. The accuracy of performance measures in COPRAS (The multi-attribute COmplex PRoportional ASsessment of alternatives) method is usually assumed to be accurate. This method assumes direct and proportional dependence of the weight and utility degree of
Zavadskas, Edmundas Kazimieras, Kaklauskas, Artūras, Turskis, Zenonas, Tamošaitienė, Jolanta   +3 more
openaire   +3 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Multi-Attribute Decision Making with Weighted Description Logics.

FLAP, 2017
We introduce a decision-theoretic framework based on Description Logics (DLs), which can be used to encode and solve single stage multi-attribute de- cision problems. In particular, we consider the background knowledge as a DL knowledge base where each attribute is represented by a concept, weighted by a utility value which is asserted by the user ...
Acar, Erman, Fink, Manuel, Meilicke, Christian, Thorne, Camilo, Stuckenschmidt, Heiner   +4 more
openaire   +3 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source