Results 81 to 90 of about 8,584,194 (292)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Optimal Multi-Attribute Decision Making in Social Choice Problems [PDF]

Proceedings of the Twenty-Seventh International Joint Conference on Artificial Intelligence, 2018
My thesis solves problems of decision making when alternatives are characterized by multiple attributes, under natural restrictions on agents’ preferences that are motivated by practical and cognitive considerations.  Computing optimal decisions in these settings is often hard in general.
openaire   +3 more sources

A Multi-Attribute Pearson’s Picture Fuzzy Correlation-Based Decision-Making Method

, 2019
As a generalization of several fuzzy tools, picture fuzzy sets (PFSs) hold a special ability to perfectly portray inherent uncertain and vague decision preferences.
Dechao Sun, Dandan Luo, Hecheng Wu, Shouzhen Zeng, Yun Jin, Bo Peng   +5 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Multi-Attribute Decision-Making Model by Applying Grey Numbers

Informatica, 2009
Multi-attribute analysis is a useful tool in many economical, managerial, constructional, etc. problems. The accuracy of performance measures in COPRAS (The multi-attribute COmplex PRoportional ASsessment of alternatives) method is usually assumed to be accurate. This method assumes direct and proportional dependence of the weight and utility degree of
Zavadskas, Edmundas Kazimieras, Kaklauskas, Artūras, Turskis, Zenonas, Tamošaitienė, Jolanta   +3 more
openaire   +3 more sources

A spectrum of compromise aggregation operators for multi-attribute decision making.

, 2007
In many decision making problems, a number of independent attributes or criteria are often used to individually rate an alternative from an agent’s local perspective and then these individual ratings are combined to produce an overall assessment. Now, in
Luo, X., Jennings, N. R.
core  

A Distributed Agent-based Decision Support for Cloud Brokering [PDF]

, 2014
In goal oriented problems, decision-making is a crucial aspect aiming at enhancing the ability to make decisions by full autonomous, or supervised software agents.
Amato, Alba, Venticinque, Salvatore
core   +1 more source

Multi-Attribute Decision Making with Weighted Description Logics.

FLAP, 2017
We introduce a decision-theoretic framework based on Description Logics (DLs), which can be used to encode and solve single stage multi-attribute de- cision problems. In particular, we consider the background knowledge as a DL knowledge base where each attribute is represented by a concept, weighted by a utility value which is asserted by the user ...
Acar, Erman, Fink, Manuel, Meilicke, Christian, Thorne, Camilo, Stuckenschmidt, Heiner   +4 more
openaire   +3 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source