Results 101 to 110 of about 121,475 (299)

Modelling and optimizing multiple attribute decisions by using fuzzy sets [PDF]

The purpose of this paper is to present a coherent perspective of modeling and optimizing multiple attribute decisions by using fuzzy sets. In management practice we face most of the time the situation in which a problem have several possible solutions ...
Adina NEGRUSA, Gh. Gh. IONESCU
core  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Optimal Multi-Attribute Decision Making in Social Choice Problems [PDF]

Proceedings of the Twenty-Seventh International Joint Conference on Artificial Intelligence, 2018
My thesis solves problems of decision making when alternatives are characterized by multiple attributes, under natural restrictions on agents’ preferences that are motivated by practical and cognitive considerations.  Computing optimal decisions in these settings is often hard in general.
openaire   +2 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Development, test and comparison of two Multiple Criteria Decision Analysis(MCDA) models: A case of healthcare infrastructure location [PDF]

, 2015
When planning a new development, location decisions have always been a major issue. This paper examines and compares two modelling methods used to inform a healthcare infrastructure location decision. Two Multiple Criteria Decision Analysis (MCDA) models
Bamford, D, Bamford, David, Dehe, B, Dehe, Benjamin   +3 more
core   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Ranking Alternatives on the Basis of a Dominance Intensity Measure [PDF]

, 2010
The additive multi-attribute utility model is widely used within MultiAttribute Utility Theory (MAUT), demanding all the information describing the decision-making situation. However, these information requirements can obviously be far too strict in many
Jiménez Martín, Antonio, Moreno Díaz, Arminda, Aguayo Garcia, Ernesto Aaron, Mateos Caballero, Alfonso   +3 more
core   +1 more source

Discrete Pseudo-Quasi Overlap Functions and Their Applications in Fuzzy Multi-Attribute Group Decision-Making [PDF]

The overlap function, a continuous aggregation function, is widely used in classification, decision-making, image processing, etc. Compared to applications, overlap functions have also achieved fruitful results in theory, such as studies on the ...
Xiaohong Zhang, Mei Jing, Mei Wang, Jingqian Wang   +3 more
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source