Results 91 to 100 of about 483,637 (297)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Ranking Alternatives on the Basis of the Intensity of Dominance and Fuzzy Logic within MAUT [PDF]
, 2010 We introduce dominance measuring methods to derive a ranking of alternatives to deal with incomplete information in multi-criteria decision making problems on the basis of Multi-Attribute Utility Theory (MAUT).
Jiménez Martín, Antonio +2 more
core +1 more source
Generalized Choquet-like aggregation functions for handling bipolar scales [PDF]
, 2006 International audienceWe are interested in modeling interaction between criteria in Multi-Criteria Decision Making when underlying scales are bipolar.
Grabisch, Michel, Labreuche, Christophe
core +3 more sources
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Dominance Measuring Approach using Stochastic Weights
, 2010 In this paper we propose an approach to obtain a ranking of alternatives in multicriteria decision-making problems when there is imprecision concerning the alternative performances, component utility functions and weights.
Aguayo Garcia, Ernesto Aaron +3 more
core
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Multicriteria Modelling of Irrigation Water Market at Basin Level [PDF]
This paper develops a multi-criteria methodology to simulate irrigation water markets at basin level. For this purpose it is assumed that irrigators try to optimise personal multi-attribute utility functions via their productive decision making process ...
José A. Gómez-Limón +1 more
core
Intelligent protocol adaptation for enhanced medical e-collaboration [PDF]
, 2003 Copyright @ 2003 AAAIDistributed multimedia e-health applications have a set specific requirements which must be taken into account effective use is to be made of the limited resources provided by public telecommunication networks.
Frank, AO, Ghinea, G, Magoulas, GD
core
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Sensitivity Analysis of TOPSIS Technique: The Results of Change in the Weight of One Attribute on the Final Ranking of Alternatives [PDF]
Journal of Optimization in Industrial Engineering, 2011 Most of data in Multi-attribute decision making (MADM) problems are changeable rather than constant and stable. Therefore, sensitivity analysis after problem solving can effectively contribute to making accurate decisions.
Alireza Alinezhad, Abbas Amini
doaj