Results 71 to 80 of about 9,250,502 (285)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Coherence and correspondence in engineering design: informing the conversation and connecting with judgment and decision-making research

Judgment and Decision Making, 2009
I show how the coherence/correspondence distinction can inform the conversation about decision methods for engineering design. Some engineers argue for the application of multi-attribute utility theory while others argue for what they call heuristics. To
Konstantinos V. Katsikopoulos, Philip T. Dunwoody, Robin Hogarth   +2 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

KomoTrip: a multi-day travel itinerary recommendation method based on the discrete komodo mlipir algorithm [PDF]

PeerJ Computer Science
Technological developments in recent years led to the emergence of increasingly sophisticated recommender systems to support multi-day travel itineraries that fall under the Tourist Trip Design Problem (TTDP). Various problem analogies are widely used to
Z. K. Abdurahman Baizal, Soni Fajar Surya Gumilang, Rio Nurtantyana, Rahmat Hendrawan   +3 more
doaj   +2 more sources

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

METHOD FOR REFINING WEIGHTS IN MULTI-CRITERIA UTILITY FUNCTION IN MAUT

KPI Science News
Background. In modern multi-criteria decision-making, a critical challenge is the determination of weight coefficients in the utility function. Classical MAUT (Multi-Attribute Utility Theory) methods often rely on subjective expert evaluations, leading ...
Viktoriia Polutsyhanova, Serhii Smyrnov   +1 more
doaj   +1 more source

Model of Human Error Probability based on dual-phase approach for learning process in cognitive-oriented tasks

International Journal of Industrial Engineering and Management, 2020
Human Error Probability (HEP) is a key element in the chain of events that could lead up to system accidents and despite the efforts of recently studies to evaluate the human reliability, many of the limitations and problems have not yet been solved. The
F. Facchini, S. Digiesi, G. Mummolo
doaj   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source

A novel Hellinger distance-based regret theory method for spherical fuzzy decision making model and its application in logistics

Scientific Reports
Actual decision making problems are often based on the company decision maker’s behavior factors, such as risk attitude, subjective preference, etc. Regret theory can well express the behavior of the decision maker.
Haiping Ren, Hui Zhou
doaj   +1 more source

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi, Giorgio Ricciardiello Mejia, Andre Metzger, Kang Hyun Ryu, Salonee Marwaha, Eva Grzegorczyk, Li Zhou, Eliana Jacobs, Boris Gilyadov, Claudia Kunney, Liqhwa Ncube, Ankit Parekh, Emmanuel Mignot, Fanny M. Elahi, Joseph Winer, Kathleen Poston, Andreas Brink‐Kjaer, Emmanuel H. During   +17 more
wiley   +1 more source