Results 81 to 90 of about 2,755,308 (302)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Multi-authority attribute-based access control system in mHealth with traceability
Tongxin xuebao, 2018 Mobile healthcare (mHealth) is an emerging technology which facilitates the share of personal health records (PHR),however,it also brings the risk of the security and privacy of PHR.Attribute-based encryption (ABE) is regarded as a new cryptology to ...
Qi LI, Hongbo ZHU, Jinbo XIONG, Ruo MO
doaj
Bringing Care Governance to Ontario's Retirement Homes Sector
Health Reform Observer - Observatoire des Réformes de Santé, 2019 In 2010, the Ontario government introduced Bill 21, the Retirement Homes Act, 2010 (the Act), which required the licensing of retirement homes (RHs), residents' rights, care and safety standards, inspections, compliance and a newly formed Retirement ...
Blair Roblin +3 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Types of Multi-Level Governance [PDF]
The reallocation of authority upwards, downwards, and sideways from central states hasdrawn attention from a growing number of scholars in the social sciences.
Liesbet Hooghe, Gary Marks
core
Healthy communities: frequent GP attenders and their use of health services in 2012–13 [PDF]
, 2015 More than one-third of Australians (35.3%) went to a GP six or more times in 2012–13, and those who went most often tended to be older and less wealthy, were more likely to have several long-term health conditions and were more likely to see several ...
National Health Performance Authority
core