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Element 5 List of Courses Core General Education Assessment, 2021-2022

open access: yes, 2022
The List of Courses for Element 5 - Social Science as part of the institution’s ongoing general education Core assessment ...
Undergraduate Core Oversight Committee, Wright State University
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Multi-Threading a State-of-the-Art Maximum Clique Algorithm

open access: yesAlgorithms, 2013
We present a threaded parallel adaptation of a state-of-the-art maximum clique algorithm for dense, computationally challenging graphs. We show that near-linear speedups are achievable in practice and that superlinear speedups are common.
Patrick Prosser, Ciaran McCreesh
doaj   +1 more source

Element 4 Letter to Chairs from UCOC Core General Education Assessment, 2023-2024

open access: yes, 2023
The Letter to Chairs from UCOC for Element 4 - Arts/Humanities as part of the institution’s ongoing general education Core assessment ...
Undergraduate Core Oversight Committee, Wright State University
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Data marshaling for multi-core architectures [PDF]

open access: yesProceedings of the 37th annual international symposium on Computer architecture, 2010
Previous research has shown that Staged Execution (SE), i.e., dividing a program into segments and executing each segment at the core that has the data and/or functionality to best run that segment, can improve performance and save power. However, SE's benefit is limited because most segments access inter-segment data
M. Aater Suleman   +4 more
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

The SCC and the SICSA multi-core challenge [PDF]

open access: yes, 2011
Two phases of the SICSA Multi-core Challenge have gone past. The first challenge was to produce concordances of books for sequences of words up to length N; and the second to simulate the motion of N celestial bodies under gravity.
Cockshott, W.P., Koliousis, A.
core  

High performance deep packet inspection on multi-core platform [PDF]

open access: yes, 2009
Deep packet inspection (DPI) provides the ability to perform quality of service (QoS) and Intrusion Detection on network packets. But since the explosive growth of Internet, performance and scalability issues have been raised due to the gap between ...
Wang, Xiaojun   +5 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

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