Results 51 to 60 of about 41,062 (305)

Multi-Core optimization technology of unstructured grid based on Sunway TaihuLight [PDF]

Jisuanji gongcheng, 2019
In order to solve discrete memory access problem of unstructured grid in high performance computing,this paper proposes a general multi-core optimization algorithm according to the architecture features of the heterogeneous multi-core processor SW26010 ...
NI Hong, LIU Xin
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Enhancing Solar Convection Analysis With Multi‐Core Processors and GPUs

Engineering Reports
In the realm of astrophysical numerical calculations, the demand for enhanced computing power is imperative. The time‐consuming nature of calculations, particularly in the domain of solar convection, poses a significant challenge for Astrophysicists ...
Arash Heidari, Zahra Amiri, Mohammad Ali Jabraeil Jamali, Nima Jafari Navimipour   +3 more
doaj   +1 more source

Architectural-Space Exploration of Heterogeneous Reliability and Checkpointing Modes for Out-of-Order Superscalar Processors

IEEE Access, 2019
State-of-the-art reliability techniques and mechanisms deploy full-scale redundancy, like double or triple modular redundancy (DMR, TMR), on different layers of the computing stack to detect and/or correct such transient faults.
Bharath Srinivas Prabakaran, Mihika Dave, Florian Kriebel, Semeen Rehman, Muhammad Shafique   +4 more
doaj   +1 more source

Scalable parallelization of skyline computation for multi-core processors [PDF]

2015 IEEE 31st International Conference on Data Engineering, 2015
The skyline is an important query operator for multi-criteria decision making. It reduces a dataset to only those points that offer optimal trade-offs of dimensions. In general, it is very expensive to compute. Recently, multicore CPU algorithms have been proposed to accelerate the computation of the skyline.
Sean Chester, Darius Sidlauskas, Ira Assent, Kenneth S. Bøgh   +3 more
openaire   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A lock circuit for a multi-core processor [PDF]

, 2015
An integrated circuit comprising a multiple processor cores and a lock circuit that comprises a queue register with respective bits set or reset via respective, connections dedicated to respective processor cores, whereby the queue register identifies ...
Strøm, Torur Biskopstø
core  

Optimizing Large Language Models on Multi-Core CPUs: A Case Study of the BERT Model

Applied Sciences
The BERT model is regarded as the cornerstone of various pre-trained large language models that have achieved promising results in recent years. This article investigates how to optimize the BERT model in terms of fine-tuning speed and prediction ...
Lanxin Zhao, Wanrong Gao, Jianbin Fang
doaj   +1 more source

NeuroFlow: A General Purpose Spiking Neural Network Simulation Platform using Customizable Processors

Frontiers in Neuroscience, 2016
NeuroFlow is a scalable spiking neural network simulation platform for off-the-shelf high performance computing systems using customizable hardware processors such as Field-Programmable Gate Arrays (FPGAs).
Kit eCheung, Kit eCheung, Simon R Schultz, Wayne eLuk   +3 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source