Results 61 to 70 of about 41,062 (305)
Garbage collection auto-tuning for Java MapReduce on Multi-Cores [PDF]
, 2011 MapReduce has been widely accepted as a simple programming pattern that can form the basis for efficient, large-scale, distributed data processing. The success of the MapReduce pattern has led to a variety of implementations for different computational ...
Brown, G. +7 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
System-Level Software for a Multi-Core MERASA Processor [PDF]
, 2009 In the EC FP-7 MERASA project a hard real-time capable multi-core processor is developed. The system-level software represents an abstraction layer between application software and embedded hardware. It has to provide basic functionalities of a real-time
Wolf, Julian, Kluge, Florian
core
Realization and Application of Shenwei Simultaneous Multithreading Functional Simulator [PDF]
Jisuanji gongcheng, 2016 imultaneous Multithreading(SMT) allows irrelevant instructions execute synchronously from multiple threads.It achieves the combination of Thread-level Parallelism(TLP) and Instruction-level Parallelism(ILP),enhances the performance of processor further ...
CHEN Weijian,GUO Yong,YIN Fei
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
An efficient processor allocation strategy that maintains a high degree of contiguity among processors in 2D mesh connected multicomputers [PDF]
, 2007 Two strategies are used for the allocation of jobs to processors connected by mesh topologies: contiguous allocation and non-contiguous allocation. In non-contiguous allocation, a job request can be split into smaller parts that are allocated to non ...
Ould-Khaoua, M. +7 more
core +1 more source
ESAIR: A Behavior-Based Robotic Software Architecture on Multi-Core Processor Platforms
International Journal of Automation and Smart Technology, 2013 This paper introduces an Embedded Software Architecture for Intelligent Robot systems (ESAIR) that addresses the issues of parallel thread executions on multi-core processor platforms. ESAIR provides a thread scheduling interface to improve the execution
Chin-Yuan Tseng +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source