Results 71 to 80 of about 22,844 (300)
Processors Allocation for MPSoCs With Single ISA Heterogeneous Multi-Core Architecture
IEEE Access, 2017 Single-instruction set architecture (ISA) heterogeneous multi-processor architecture is promising for developing multi-processor system-on-chips (MPSoCs). In this architecture, all processors execute the same instruction set, yet with various performance
Yi-Jung Chen +5 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Sukkur IBA Journal of Computing and Mathematical Sciences, 2017 In last decade, application developers attained improved performances by merely employing the machines based on higher-clocked processors. However, in 2003 multi-core processors emerged and eradicated the old processor manufacturing technology based on ...
Badri Munier +4 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Capability for Multi-Core and Many-Core Memory Systems: A Case-Study With Xeon Processors
IEEE Access, 2019 The general volume of data has exploded to unimaginable levels in the past decade. Therefore, the big data analytics has become an area of focus. Many frameworks have been developed for data analytics, such as Hadoop, Spark, etc.
Yuxuan Xing +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Estudo de casos com aplicações científicas de alto desempenho em agregados de computadores multi-core [PDF]
, 2008 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-graduação em Ciência da ComputaçãoEste trabalho de disserta»c~ao concentra seu esfor»co no estudo emp¶³rico de tr^es casos com ambientes de cluster ...
Silva Filho, Luiz Carlos Pinto
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source