Results 81 to 90 of about 22,844 (300)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Performance evaluation of multi-core multi-cluster architecture

, 2014
A multi-core cluster is a cluster composed of numbers of nodes where each node has a number of processors, each with more than one core within each single chip. Cluster nodes are connected via an interconnection network.
Walters, Robert John, Hamid, Norhazlina, Wills, Gary B., Walters, Robert J., Wills, Gary Brian   +4 more
core  

FPGA multi-core processors power consumption: soft- core vs. hard-core

, 2018
Actually multi-core processors designs are limited in power consumption and performance. Consequently, it is not possible to optimize further the performance without increasing power consumption.
Kallbaqi, Gerti, Gerti Kallbaqi, Marsida Ibro, Ibro, Marsida   +3 more
core   +1 more source

TECHNOLOGY DEVELOPMENT OF PARALLEL PROGRAMS FOR MODERN MULTICORE PROCESSORS

Статистика и экономика, 2016
The possibilities of advanced technologies for programming the multi-core processors, aimed at both the automatic adaptation of existing sequential soft-ware under the mandatory approach, and to develop accurate multipolar applications by means of modern
Aleksandr V. Bakulev, Marina A. Bakuleva, Maksim A. Kozlov, Sergei V. Skvortsov   +3 more
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

An efficient geosciences workflow on multi-core processors and GPUs: a case study for aerosol optical depth retrieval from MODIS satellite data

, 2016
Quantitative remote sensing retrieval algorithms help understanding the dynamic aspects of Digital Earth. However, the Big Data and complex models in Digital Earth pose grand challenges for computation infrastructures. In this article, taking the aerosol
Feld, Dustin, Pan, Peiyuan, Fraunhofer Institute of Algorhithms and Scientific Computing, Soddemann, Thomas, Liu, Jia, Xue, Yong, Garcke, Jochen   +6 more
core   +1 more source