Results 41 to 50 of about 4,409,486 (310)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Technological and Economic Development of Economy, 2013 Higher education refers to a level of education that is provided at academies, universities, colleges, seminaries, institutes of technology, and certain other collegiate-level institutions.
Cengiz Kahraman
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
On prioritized weighted aggregation in multi-criteria decision making [PDF]
, 2010 This paper deals with multi-criteria decision making (MCDM) problems with multiple priorities, in which priority weights associated with the lower priority criteria are related to the satisfactions of the higher priority criteria.
Nakamori, Yoshiteru +7 more
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From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
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Evaluation criteria for a systemic approach to flood risk management: stakeholders’ perspectives
TechneFlood risk management authorities rely on structural engineering measures centralised at the spatial and governance levels. These are mainly evaluated based on damage reduction without considering social, economic and environmental criteria. The research
Francesca Vanelli +2 more
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Multi-criteria Decision Making with Fuzzy Targets [PDF]
, 2007 This paper discusses the issue of how to solve multi-criteria decision making (MCDM) problems from the target perspective. In particular, instead of making use of the traditional normalization method, it tries to calculate the probability of meeting some
Nakamori, Yoshiteru +2 more
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
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Multi-criteria decision-making for solving transport sustainability issues: an overview
TransportWith the recognition of the impact of the transport sector on climate change and human health, decision-makers are under the pressure to shape the transport sector in a more sustainable way, considering more sustainable options and technologies. Besides
Indrė Šikšnelytė-Butkienė +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
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