Results 41 to 50 of about 559,365 (305)
Comparison of different Multiple-criteria decision analysis methods in the context of conceptual design: application to the development of a solar collector structure [PDF]
, 2014 At each stage of the product development process, the designers are facing an important task which consists of decision making. Two cases are observed: the problem of concept selection in conceptual design phases and, the problem of pre-dimensioning once
EL AMINE, Mehdi +2 more
core
Explaining Results of Multi‐Criteria Decision‐Making
Journal of Multi-Criteria Decision AnalysisABSTRACTTransparency in computing is an important precondition to ensure the trust of users. One concrete way of delivering transparency is to provide explanations of computing results. To this end, we introduce a method for explaining the results of various linear and hierarchical multi‐criteria decision‐making (MCDM) techniques such as the weighted ...
Martin Erwig, Prashant Kumar
openaire +2 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Fuzzy Measures in Multi-Criteria Decision Making
Procedia Computer Science, 2015 AbstractWe are interested in the formulation of multi-criteria decision functions based on the use of a measure over the space of criteria. Specifically the relationship between the criteria is expressed using a fuzzy measure. We then use the Choquet integral to construct decision functions based on the measure.
Ronald R. Yager, Naif Alajlan
openaire +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
, 2022 To enhance preparedness for diverse pandemic situations we aim to predict the performance of various pharmaceutical intervention strategies. We gathered domain experts and ran a series of decision conferences where a scenario-based multi-criteria ...
Tobias Fasth +13 more
core +1 more source