Results 131 to 140 of about 1,234,846 (256)

WHY FUZZY ANALYTIC HIERARCHY PROCESS APPROACH FOR TRANSPORT PROBLEMS? [PDF]

The evaluation of transport projects has become increasingly complex. Different aspects have to be taken into account and the consequences of the problems are usually far reaching and the different policy alternatives are numerous and difficult to ...
Senay Oguztimur
core  

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

A Comparative Analysis of Multi-Criteria Decision-Making Methods

Engineering, Technology & Applied Science Research
Multi-Criteria Decision-Making (MCDM) techniques have found widespread application across diverse fields. The rapid evolution of MCDM algorithms has led to the development of hundreds of methods, each employing a distinct approach. Due to the inherent algorithmic differences, various MCDM methods often produce divergent results when applied to the same
Hien, Nguyen Thi Thu, Quynh, Pham Huong, Minh, Vu Quang   +2 more
openaire   +2 more sources

Influence of aggregation and measurement scale on ranking a compromise alternative in AHP [PDF]

Analytic Hierarchy Process (AHP) is one of the most popular multi-attribute decision aid methods. However, within AHP, there are several competing preference measurement scales and aggregation techniques.
Balkenborg, Dieter, Ishizaka, Alessio, Kaplan, Todd   +2 more
core   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Creating A Multi-Criteria Decision Analysis Tool to Enhance Value-Based Purchasing of Generic and Biosimilar Medications in Saudi Arabia: A Pilot Study

ClinicoEconomics and Outcomes Research
Yazed Alruthia,1,2 Horiyah Alhajri,1 Omar A Almohammed,1 Bander Balkhi,1 Mai F Alsaqa’aby,2 Mohammed A Almuqbil,3– 5 Hana A Al-Abdulkarim,6 Abdulaali R Almutairi7 1Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi ...
Alruthia Y, Alhajri H, Almohammed OA, Balkhi B, Alsaqa’aby MF, Almuqbil MA, Al-Abdulkarim HA, Almutairi AR   +7 more
doaj  

An integrated MCDA software application for forest planning : a case study in southwestern Sweden [PDF]

, 2011
Forest planning in Sweden today translates not only into planning of timber production, but also for the provision of other functions and services.
Eriksson, Ljusk Ola, Korosuo, Anu, Wikström, Peder, Öhman, Karin   +3 more
core  

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

A state-of-the-art multi-criteria model for drug benefit-risk analysis [PDF]

Drug benefit-risk analysis is based on firm clinical evidence related to various safety and efficacy outcomes, such as tolerability, treatment response, and adverse events.
Buskens, E., Hillege, H.L., Postmus, D., Tervonen, T.   +3 more
core   +1 more source