Results 61 to 70 of about 417,433 (305)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Multi-Criteria Decision Analysis for Aiding Glyph Design

IEEE Transactions on Visualization and Computer Graphics
Glyph-based visualization is one of the main techniques for visualizing complex multivariate data. With small glyphs, data variables are typically encoded with relatively low visual and perceptual precision. Glyph designers have to contemplate the trade-offs in allocating visual channels when there is a large number of data variables.
Hong-Po Hsieh, Amy Zavatsky, Min Chen 0001   +2 more
openaire   +3 more sources

Optimal management of adults with pharyngitis – a multi-criteria decision analysis [PDF]

BMC Medical Informatics and Decision Making, 2006
Abstract Background Current practice guidelines offer different management recommendations for adults presenting with a sore throat. The key issue is the extent to which the clinical likelihood of a Group A streptococcal infection should affect patient management decisions.
Sonal Singh, James G. Dolan, Robert M. Centor   +2 more
openaire   +3 more sources

Non-additive multi-attribute fuzzy target-oriented decision analysis [PDF]

, 2013
As an emerging area considering behavioral aspects of decision making, target-oriented decision model lies in the philosophical root of bounded rationality as well as represents the S-shaped value function.
Nakamori, Yoshiteru, Ma, Tieju, Yan, Hong-Bin, Huynh, Van-Nam   +3 more
core   +1 more source

Ratio product model: A rank-preserving normalization-agnostic multi-criteria decision-making method

, 2023
This paper presents a new multi-criteria decision-making (MCDM) method, namely the ratio product model (RPM). We first overview two popular aggregating models: the weighted sum model (WSM) and the weighted product model (WPM). Then, we argue that the two
Rezaei, J., Mohammadi, Majid (author), Mohammadi, Majid, Rezaei, J. (author)   +3 more
core   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Foreign experience of decision analysis application in solving environmental problems

Ученые записки Российской академии предпринимательства, 2021
The article is devoted to the analysis of foreign experience of decision analysis application in solving environmental problems. Multi-criteria decision analysis methods approved in various countries are considered.
V. S. Kharchenko
doaj  

Integrating multiple criteria decision analysis into participatory forest planning [PDF]

, 2010
Following the development of sustainable forest management, the focus of forest planning has shifted from being exclusively concerned with timber production to encompassing other benefits of forests as well, e.g. biodiversity and recreation.
Nordström, Eva-Maria
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Determining what represents value in the treatment of prurigo nodularis and its key unmet needs in Spain through Multi‐Criteria Decision Analysis

JEADV Clinical Practice
Background Prurigo nodularis (PN) is a chronic, debilitating dermatologic disease characterised by the presence of highly pruritic nodular lesions. PN highly impacts on patients' quality of life as there are no specific treatments available in Spain ...
Juan Francisco Silvestre, M. J. Tribó, José C. Armario‐Hita, Miguel Ángel Calleja‐Hernández, Francisco Javier Ortiz‐Frutos, José Luis Poveda, John Shepherd, Esther Serra‐Baldrich   +7 more
doaj   +1 more source