Results 31 to 40 of about 457,615 (216)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Development and Application of an Interval-Valued Pythagorean Fuzzy Set-Based Grade Evaluation Method to Foreign Fiber Content

Journal of Natural Fibers, 2023
To solve the problem of the grade evaluation of foreign fiber content in cotton, this paper divided the problem into multi-criteria decision-making field and proposed an interval-valued Pythagorean fuzzy set foreign fiber content grade evaluation method.
Weijia Ren, Yuhong Du
doaj   +1 more source

MULTI-CRITERIA EVALUATION OF THE MULTIFACTOR STOCHASTIC SYSTEMS EFFECTIVENESS

Сучасні інформаційні системи, 2023
Subject of the research in the article is the evaluation of complex multifactor stochastic systems functioning effectiveness according to a variety of correlated criteria. The problem actuality is determined by the fact that an independent evaluation of
Lev Raskin, Larysa Sukhomlyn, Dmytro Sokolov, Vitalii Vlasenko   +3 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Two-step procedure for multi-criteria choice of generating-capacity structure in remote areas

E3S Web of Conferences, 2019
The paper dwells upon the problem of multi-criteria choice of ways to develop generating capacities to supply power to remote consumers. We herein propose a two-step multi-criteria analysis method: choosing promising power-generation technology first ...
Nefedov Aleksandr, Shakirov Vladislav
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Evaluation of antiarrhythmia drug through QSPR modeling and multi criteria decision analysis

Scientific Reports
This study explores how topological indices (TIs), which are mathematical descriptors of a drug’s molecular structure, can support to predict vital properties and biological activities. This understanding is a key for more effective drug design.
Shereen Iqbal, Hifza Iqbal, Muhammad Akhtar Tarar, Muhammad Farhan Hanif, Osman Abubakar Fiidow   +4 more
doaj   +1 more source

Generative design process: multi-criteria evaluation and multidisciplinary approach

Techne, 2021
The paper shows the results of an applied research carried out at the Department of Architecture, Roma Tre University, to integrate a multi-criteria method in the generative design process of envelope refitting with the aim of implementing a holistic ...
Adolfo Francesco Lucio Baratta, Fabrizio Finucci, Antonio Magarò   +2 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Multi-Criteria Evaluation of Environmentally Friendly Alternative Fuels

Engineering Proceedings
In order to fulfil the environmental goals set for the coming years, industrial companies are motivated to look for clean technologies and green solutions.
Dominika Kraviarová, Ján Janošovský, Miroslav Variny   +2 more
doaj   +1 more source