Results 41 to 50 of about 116,404 (257)

FORMALIZING THE PROBLEM OF A PROJECT TEAM BULDING BASED ON THE UTILITY THEORY

Сучасний стан наукових досліджень та технологій в промисловості, 2017
The subject matter of the article is mathematical models for solving particular problems of sorting out candidates for a project team. The aim is to create a region of compromises for a variety of particular criteria for selecting candidates and to ...
Nataliia Kosenko, Iryna Kadykova, Roman Artiukh   +2 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Multi-criteria problem of optimization

Vestnik Kostroma State University. Series: Pedagogy. Psychology. Sociokinetics, 2019
General subjects of teaching technics connected with minimisation by metrics are under consideration.The effectiveness of studying the possibilities of mathematical modelling in applied economical problems depends not only on studying the basic section of operation research, but also on the skill of finding the resolution of non-typical situation ...
Yelena I. Kuimova, Dmitriy A. Ryabov
openaire   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Evolutionary Multi-Criteria Optimization: Methods and Applications

Mathematics
Complex problems usually require the simultaneous consideration of multiple performance criteria within multidisciplinary environments [...]
Shi Cheng, Rui Wang
doaj   +1 more source

Neuro-Evolutionary Synthesis of Game Models of Control under Uncertainty Based on Distributed Computing Technology

Engineering Proceedings, 2023
The methodology basic principles of the neuro-evolutionary synthesis of multi-object multi-criteria systems control models under conflict and uncertainty in real time are discussed.
Vladimir A. Serov, Daria L. Popova, Pavel P. Rogalev, Anastasia V. Tararina   +3 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Multi criteria optimization of mechatronic system based on equilibrium-arbitrary compromise

RUDN Journal of Engineering Research, 2010
This article considers a multiply connected mechatronic system of the telescope drive that consists of three subsystems - mechanical, executive and computer in conditions of structural inconsistency and uncertainty.
A A Vaganyan, E M Voronov
doaj  

Development of an Adaptive Multi-Criteria Optimization Framework Using the PSI Method: Validation via Thermal Insulation Selection

Science, Engineering and Technology
Multi-criteria optimization is primarily utilized to rank various alternatives and project types. However, the question arises: is it possible to use the multi-criteria optimization process for something more than that, in terms of determining the actual
Srđan Vasković, Petar Gvero, Milovan Kotur, Đorđe Vojinović, Ljubiša Preradović, Danijela Kardaš-Ančić, Milan Pupčević   +6 more
doaj   +1 more source