Results 51 to 60 of about 295,143 (299)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Scalarizing cost-effective multiobjective optimization algorithms made possible with kriging

, 2007
The use of kriging in cost-effective single-objective optimization is well established, and a wide variety of different criteria now exist for selecting design vectors to evaluate in the search for the global minimum.
Jan Sykulski, Hawe, G.I., Hawe, G., Sykulski, J.K., Glenn Hawe   +4 more
core   +1 more source

Definition of criteria and alternatives for choosing the optimal mining method deposits when applying multi: Criteria optimization [PDF]

Podzemni Radovi
When solving real problems, and to make a quality decision, it is necessary to consider a great number of often complex parameters. For these reasons, the development of decision-making process modeling has seen significant growth in recent years, and ...
Bajić Sanja, Bajić Dragoljub, Gluščević Branko, Gaćina Radmila, Išek Josip   +4 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Comparison of different Multiple-criteria decision analysis methods in the context of conceptual design: application to the development of a solar collector structure [PDF]

, 2014
At each stage of the product development process, the designers are facing an important task which consists of decision making. Two cases are observed: the problem of concept selection in conceptual design phases and, the problem of pre-dimensioning once
EL AMINE, Mehdi, PAILHES, Jerome, PERRY, Nicolas   +2 more
core  

Determining a Robust, Pareto Optimal Geometry for a Welded Joint [PDF]

, 2014
Multi-criteria optimization problems are known to give rise to a set of Pareto optimal solutions where one solution cannot be regarded as being superior to another.
Radhi, Hazim E., Barrans, Simon, Barrans, Simon M., Radhi, H.E.   +3 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

A Geographical-Based Multi-Criteria Approach for Marine Energy Farm Planning [PDF]

, 2014
The objective of this paper is to devise a strategy for developing a flexible tool to efficiently install a marine energy farm in a suitable area. The current methodology is applied to marine tidal current, although it can be extended to other energy ...
Christophe Claramunt, Jean-Frédéric Charpentier, CHARPENTIER, Jean-Frederic, MASLOV, Nicolas, BROSSET, David, Nicolas Maslov, David Brosset, CLARAMUNT, Christophe   +7 more
core   +1 more source

Development of an Adaptive Multi-Criteria Optimization Framework Using the PSI Method: Validation via Thermal Insulation Selection

Science, Engineering and Technology
Multi-criteria optimization is primarily utilized to rank various alternatives and project types. However, the question arises: is it possible to use the multi-criteria optimization process for something more than that, in terms of determining the actual
Srđan Vasković, Petar Gvero, Milovan Kotur, Đorđe Vojinović, Ljubiša Preradović, Danijela Kardaš-Ančić, Milan Pupčević   +6 more
doaj   +1 more source