Results 51 to 60 of about 62,190 (261)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Quaternion-Domain Super MDS for Robust 3D Localization

IEEE Open Journal of Signal Processing
This paper proposes a novel low-complexity three-dimensional (3D) localization algorithm for wireless sensor networks, termed quaternion-domain super multi-dimensional scaling (QD-SMDS).
Alessio Lukaj, Keigo Masuoka, Takumi Takahashi, Giuseppe Thadeu Freitas de Abreu, Hideki Ochiai   +4 more
doaj   +1 more source

Wavevector anisotropy of plasma turbulence at ion kinetic scales: solar wind observations and hybrid simulations [PDF]

Nonlinear Processes in Geophysics, 2014
Wavevector anisotropy of ion-scale plasma turbulence is studied at various values of ion beta. Two complementary methods are used. One is multi-point measurements of magnetic field in the near-Earth solar wind as provided by the Cluster spacecraft ...
H. Comişel, Y. Narita, U. Motschmann
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Simulation of Novel Nano Low-Dimensional FETs at the Scaling Limit

Nanomaterials
The scaling of bulk Si-based transistors has reached its limits, while novel architectures such as FinFETs and GAAFETs face challenges in sub-10 nm nodes due to complex fabrication processes and severe drain-induced barrier lowering (DIBL) effects.
Pengwen Guo, Yuxue Zhou, Haolin Yang, Jiong Pan, Jiaju Yin, Bingchen Zhao, Shangjian Liu, Jiali Peng, Xinyuan Jia, Mengmeng Jia, Yi Yang, Tianling Ren   +11 more
doaj   +1 more source

Does multi-way, long-range chromatin contact data advance 3D genome reconstruction?

BMC Bioinformatics, 2023
Background Methods for inferring the three-dimensional (3D) configuration of chromatin from conformation capture assays that provide strictly pairwise interactions, notably Hi-C, utilize the attendant contact matrix as input.
Adam B. Olshen, Mark R. Segal
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Sustainability index analysis for environmentally low-input integrated farming [PDF]

Global Journal of Environmental Science and Management
BACKGROUND AND OBJECTIVES: Integrated farming is an efficient and environmentally friendly agricultural activity that uses low-input resources, including abundant local materials, such as waste.
E. Widjaja, B.N. Utomo, A.D. Santoso, Y.P. Erlambang, . Surono, M.A. Firmansyah, S. Handoko, E. Erythrina, M.N. Rofiq, D. Iskandar, N.A. Sasongko, T. Rochmadi, N. Abbas, M. Hanif, Y.S. Garno, F.D. Arianti, N.D. Suretno, M. Askinatin, C.O.I. Hastuti, F. Fahrodji   +19 more
doaj   +1 more source

THE SUSTAINABILITY DEVELOPMENT STATUS OF PIGS LIVESTOCK ON TRADITIONAL FISHERY HOUSEHOLD IN NEMBRALA VILLAGE OF ROTE NDAO ISLAND [PDF]

Russian Journal of Agricultural and Socio-Economic Sciences, 2018
This study aims to determine the status of corporate sustainability on a pig livestock in the village of fishermen household in Rote Ndao Island. Data were analyzed using the approach of Multi-Dimensional Scaling.
Paulus C.A., Sobang Y.U.L., Pellokila M.R., Azmanajaya E.   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source