Results 61 to 70 of about 62,190 (261)
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
ML-Based Autoscaling for Elastic Cloud Applications: Taxonomy, Frameworks, and Evaluation
Mathematical and Computational ApplicationsElastic cloud systems are increasingly employing machine learning (ML) to automate resource scaling in response to variable workloads and stringent service-level objectives. However, current ML-based autoscalers are fragmented across different platforms,
Vishwanath Srikanth Machiraju +2 more
doaj +1 more source
A Unified Algorithmic Framework for Multi-Dimensional Scaling
CoRR, 2010 18 pages, 7 figures. This version fixes a bug in the proof of Theorem 6.1 (dimensionality reduction for spherical data). The statement of the result remains the same.
Arvind Agarwal +2 more
openaire +2 more sources
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
JPPI (Jurnal Penelitian Pendidikan Indonesia)Sebagai perguruan tinggi yang sedang tumbuh dan berkembang, Politeknik Baubau dituntut mengembangkan keunggulan dan keunikan yang dimiliki agar mampu bersaing dengan perguruan tinggi lain disekitarnya.
Muhammad Risal Tawil, Ansar Ansar
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FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells
FEBS Open Bio, EarlyView.To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai +8 more
wiley +1 more source
Dianxin kexue, 2016 For the issues that the existing centralized multi-dimensional scaling（MDS-MAP）localization algorithms in wireless sensor network （WSN）have localization accuracy and distributed problem, a distributed real-time localization algorithm based on sparse ...
Yong MA, Yuchun LIU
doaj
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source