Results 311 to 319 of about 36,032 (319)

Evaluation of multi-epitope recombinant protein as a candidate for a contraceptive vaccine

Journal of Reproductive Immunology, 2021
Contraceptive vaccine (CV) is a valuable, non-invasive, and alternative method for purposeful contraception. Sperm antigens are useful targets for producing CVs due to their specialized expression in sperm. In this study, a recombinant protein containing three main sperm epitopes (IZUMO1, SACA3, and PH-20) was designed and evaluated as CV to control ...
Behnam Mortazavi, Najaf Allahyari Fard, Ali Asghar Karkhane, Sara Shokrpoor, Farid Heidari   +4 more
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Multi‐epitope DNA vaccines

Immunology & Cell Biology, 1997
The evolution of vaccine strategies has seen a move from whole organisms to recombinant proteins, and further towards the ultimate in minimalist vaccinology, the epitope. The epitope‐based approach is clearly compelling as only a relatively tiny, but immunologically relevant, sequence is often capable of inducing protective immunity against a large and
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A candidate multi‐epitope vaccine against Lumpy skin disease

Transboundary and Emerging Diseases, 2022
Lumpy skin disease (LSD) is a fulminant infectious disease that mostly affects cattle and causes considerable economic loss throughout the globe. This study was conducted to develop a new multi-epitope-based vaccine against LSD that can elicit immunological responses using an in silico reverse vaccinology approach.
Md Bashir Uddin, Fatema Yeasmin Tanni, Syeda Farjana Hoque, Emran Hossain Sajib, Md Atik Faysal, Md Anisur Rahman, Asaduzzaman Galib, Ahsan Al Emon, Md Mukter Hossain, Mahmudul Hasan, Syed Sayeem Uddin Ahmed   +10 more
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Vaccinomics approach for developing multi-epitope peptide pneumococcal vaccine

Journal of Biomolecular Structure and Dynamics, 2019
Streptococcus pneumoniae is a leading cause of some diseases such as pneumonia, sepsis, and meningitis mostly in children less than 5 years of age. Presently, two types of pneumococcal vaccine are available on the market: polysaccharide vaccines (PPV) that are based on capsular polysaccharides of at least 92 different serotypes, and protein-conjugated ...
Hesam Dorosti, Mahboobeh Eslami, Manica Negahdaripour, Mohammad Bagher Ghoshoon, Ahmad Gholami, Reza Heidari, Ali Dehshahri, Nasrollah Erfani, Navid Nezafat, Younes Ghasemi   +9 more
openaire   +2 more sources

Immunoplacental therapy, a potential multi-epitope cancer vaccine

Medical Hypotheses, 2006
The field of tumor immunology has made great advancements in recent years. A retrospective analysis of previous vaccine strategies combined with present knowledge may provide additional insight in this treatment modality. This article provides a review of immunoplacental therapy (IPT), a cancer vaccine consisting of chorionic villi extractions from the
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The Development of Multi-epitope Vaccines: Epitope Identification, Vaccine Design and Clinical Evaluation

Biologicals, 2001
We have developed efficient methods for epitope identification and vaccine design. Our process for epitope selection based on the combined use of motif analyses, binding assays and immunogenicity evaluations is described. We also describe how the projected population coverage and vaccine design can be optimized.
M. Newman, R. Chesnut, B. Livingston, E. Appella, J. Sidney, J. Fikes, D. McKinney, A. Sette   +7 more
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Computational design of a novel multi-epitope vaccine against Coxiella burnetii

Human Immunology, 2020
Query fever is a zoonotic disease caused by Coxiella burnetii. There is no universal method for the prevention of this disease. Recombinant vaccine is a potent strategy that can be utilized for this purpose. The current study was conducted to develop a multi-epitope vaccine against Coxiella burnetii. Hence, OmpA, Tuf2, GroEL, Mip and sucB antigens were
Amin Jaydari, Narges Nazifi, Ali Forouharmehr   +2 more
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The multi-epitope polypeptide approach in HIV-1 vaccine development

Genetic Analysis: Biomolecular Engineering, 1999
The application of a preventive HIV vaccine is the only hope for most developing countries to halt the AIDS pandemic. A project aimed to develop a preventive AIDS vaccine is being carried out since 1992 by three Cuban research institutions: Centro de Ingeniería Genética y Biotecnologia de La Habana, Instituto de Medicina Tropical 'Pedro Kouri' and ...
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IMMUNOGENICITY AND SPECIFICITY OF THE CANDIDATE MULTI-EPITOPE-VACCINES AGAINST HIV-1

Immunopharmacology and Immunotoxicology, 2001
The failure of some candidate HIV-1 vaccines may result from inducing very weak neutralization activity against representative primary viral isolates. Based on our hypothesis that epitope-vaccine may be a new strategy to induce high levels of neutralizing antibodies against HIV-1, we designed two candidate multi-epitope-vaccines, EP1 [C-G-(ELDKWA ...
Ying-Hua Chen, Jian Ding, Yun Lu
openaire   +3 more sources