Results 1 to 10 of about 4,155 (183)

Correction: Manganese mediates antiviral effects by driving an ATM-TBK1 phosphorylation signaling pathway [PDF]

Frontiers in Immunology
Hongyan Sui, Rosana Wiscovitch-Russo, Silvia Cachaco, Silvia Cachaco, Jun Yang, Whitney Bruchey, Sylvain Laverdure, Qian Chen, Tomozumi Imamichi   +8 more
doaj   +2 more sources

In silico single-cell metabolism analysis unravels a new transition stage of CD8 T cells 4 days post-infection

ImmunoInformatics
CD8 T cell proper differentiation during antiviral responses relies on metabolic adaptations. Herein, we investigated global metabolic activity in single CD8 T cells along an in vivo response by estimating metabolic fluxes from single-cell RNA-sequencing
Christophe Arpin, Franck Picard, Olivier Gandrillon   +2 more
doaj   +1 more source

Is the vaccination-induced B cell receptor repertoire predictable?

ImmunoInformatics
Vaccines trigger an immune response that results in a population of memory cells that can quickly respond to subsequent antigen re-encounters. Most vaccines are designed to induce memory B cells with vaccine-specific B cell receptors (BCRs).
Eve Richardson, Lisa Willemsen, Pramod Shinde, Morten Nielsen, Bjoern Peters   +4 more
doaj   +1 more source

Challenges for the immunoglobulin and T cell receptor gene nomenclatures in the modern genomics era

ImmunoInformatics
For over thirty years, an approach to the nomenclatures of human immunoglobulin (IG) and T cell receptor (TR) genes has operated successfully and has been widely supported by the research community. The principles behind the human nomenclatures were then
Andrew M. Collins, Corey T. Watson, Henk-Jan van den Ham, Luc Teyton, Elisa Rosati, Yana Safonova   +5 more
doaj   +1 more source

Structural insights on the differentiation and reversion of conformational changes in SARS-CoV-2 spike protein models across variants occurring from December, 2019 to November, 2021

ImmunoInformatics
Conformational changes in the SARS-CoV-2 spike protein are critical for understanding viral evolution. In this study, we provide comparative structural and electrostatic analyses across variants, revealing both differentiation and reversion patterns not ...
Marni E. Cueno, Kenichi Imai
doaj   +1 more source

Building immunoglobulin and T cell receptor gene databases for the future

ImmunoInformatics
Genetic databases for immunoglobulin (IG) and T cell receptor (TR) genes have evolved from small catalogs to critical resources underpinning immunogenetic research.
Corey T. Watson, Andrew M. Collins, Mats Ohlin, James M. Heather, Ayelet Peres, William D. Lees, Gur Yaari   +6 more
doaj   +1 more source

Machine learning in AIRR diagnostics: Advances and applications

ImmunoInformatics
Recent advancements in sequencing technologies have led to an exponential increase in adaptive immune receptor repertoire (AIRR) data. These receptors, crucial to the adaptive immune system, are believed to have strong potential for diagnostic ...
Aslı Semerci, Celine AlBalaa, Brian Corrie, Dylan Duchen, Gisela Gabernet, Jinwoo Leem, Enkelejda Miho, Ulrik Stervbo, Justin Barton, Pieter Meysman   +9 more
doaj   +1 more source

Do domain-specific protein language models outperform general models on immunology-related tasks?

ImmunoInformatics
Deciphering the antigen recognition capabilities by T-cell and B-cell receptors (antibodies) is essential for advancing our understanding of adaptive immune system responses.
Nicolas Deutschmann, Aurelien Pelissier, Anna Weber, Shuaijun Gao, Jasmina Bogojeska, María Rodríguez Martínez   +5 more
doaj   +1 more source

T-cell receptor binding prediction: A machine learning revolution

ImmunoInformatics
Recent advancements in immune sequencing and experimental techniques are generating extensive T cell receptor (TCR) repertoire data, enabling the development of models to predict TCR binding specificity.
Anna Weber, Aurélien Pélissier, María Rodríguez Martínez   +2 more
doaj   +1 more source

Immunoinformatics Approach for the Identification and Characterization of T Cell and B Cell Epitopes towards the Peptide-Based Vaccine against SARS-CoV-2

Archives of Medical Research, 2021
Sang Soo Lee, Manojit Bhattacharya, Chiranjib Chakraborty   +2 more
exaly