Results 41 to 50 of about 2,776 (178)

AntigenDB: an immunoinformatics database of pathogen antigens [PDF]

Nucleic Acids Research, 2009
The continuing threat of infectious disease and future pandemics, coupled to the continuous increase of drug-resistant pathogens, makes the discovery of new and better vaccines imperative. For effective vaccine development, antigen discovery and validation is a prerequisite.
Hifzur Rahman Ansari, Darren R. Flower, G. P. S. Raghava   +2 more
openaire   +4 more sources

Modeling interaction of Glioma cells and CAR T-cells considering multiple CAR T-cells bindings

ImmunoInformatics, 2023
Chimeric antigen receptor (CAR) T-cell based immunotherapy has shown its potential in treating blood cancers, and its application to solid tumors is currently being extensively investigated.
Runpeng Li, Prativa Sahoo, Dongrui Wang, Qixuan Wang, Christine E. Brown, Russell C. Rockne, Heyrim Cho   +6 more
doaj   +1 more source

Manganese mediates antiviral effects by driving an ATM -TBK1 phosphorylation signaling pathway

Frontiers in Immunology
Ataxia-telangiectasia mutated (ATM) is traditionally recognized as a nuclear kinase involved in DNA damage repair. We were the first to report that ATM also participates in a manganese (Mn)-dependent TBK1 phosphorylation pathway.
Hongyan Sui, Rosana Wiscovitch-Russo, Silvia Cachaco, Silvia Cachaco, Jun Yang, Whitney Bruchey, Sylvain Laverdure, Qian Chen, Tomozumi Imamichi   +8 more
doaj   +1 more source

Statistical deconvolution of enthalpic energetic contributions to MHC-peptide binding affinity [PDF]

, 2006
Background: MHC Class I molecules present antigenic peptides to cytotoxic T cells, which forms an integral part of the adaptive immune response. Peptides are bound within a groove formed by the MHC heavy chain. Previous approaches to MHC Class I-peptide
Hattotuwagama, C.K., Moss, David S., Davies, M.N., David S Moss, Drew, M.G.B., Channa K Hattotuwagama, Drew, Michael G.B., Flower, Darren R., Matthew N Davies, Hattotuwagama, Channa K., Davies, Matthew N., Michael GB Drew, Darren R Flower, Flower, D.R., Moss, D.S.   +14 more
core   +1 more source

Image_6_Designing a multi-epitope vaccine against coxsackievirus B based on immunoinformatics approaches.jpeg

, 2022
Coxsackievirus B (CVB) is one of the major viral pathogens of human myocarditis and cardiomyopathy without any effective preventive measures; therefore, it is necessary to develop a safe and efficacious vaccine against CVB.
Fengzhen Deng (14079264), Xinnan Hu (14079267), Yushu Deng (14079270), Wenran Zhao (6989219), Yanhang Wang (14079273), Congcong Zhang (334270), Zongmao Dai (14079261), Sichao Huang (4031558), Zhaohua Zhong (213963), Yuxuan Li (1674307), Jingjing Huang (170112), Yan Wang (15435), Xumeng Wang (12238019), Xinxin Yue (8628432), Jianing Li (359834)   +14 more
core   +1 more source

Immunoinformatics and tick vaccinology

Exploration of Immunology, 2023
Immunoinformatics is an emerging area focused on development and applications of methods used to facilitate vaccine development. There is a growing interest in the field of vaccinology centered on the new omic science named ‘vaccinomics’. However, this approach has not succeeded to provide a solution against major infections affecting both animals and ...
Rodrigo Rosario-Cruz, Delia Inés Domínguez-García, Saúl López-Silva, Fernando Rosario-Domínguez   +3 more
openaire   +1 more source

Interleukin-27-polarized HIV-resistant M2 macrophages are a novel subtype of macrophages that express distinct antiviral gene profiles in individual cells: implication for the antiviral effect via different mechanisms in the individual cell-dependent manner

Frontiers in Immunology
IntroductionInterleukin (IL)-27 is an anti-viral cytokine. IL-27-treated monocyte-derived macrophages (27-Mac) suppressed HIV replication. Macrophages are generally divided into two subtypes, M1 and M2 macrophages.
Tomozumi Imamichi, Jun Yang, Qian Chen, Suranjana Goswami, Mayra Marquez, Udeshika Kariyawasam, Homa Nath Sharma, Rosana Wiscovitch-Russo, Xuan Li, Akihiro Aioi, Joseph W. Adelsberger, Weizhong Chang, Jeanette Higgins, Hongyan Sui   +13 more
doaj   +1 more source

Targeting Amastigote and Trypomastigote Phases: Multi‐Epitope Vaccine Strategy Against Trypanosoma cruzi

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Effective vaccines against Trypanosoma cruzi, the causative agent of Chagas disease, are urgently needed. Here, we report the design and in silico validation of a novel multiepitope vaccine construct targeting the key surface proteins ASP‐2 and gp82. Using a comprehensive immunoinformatics pipeline, we identified and selected 38 potent T‐cell (
Maria Karolaynne da Silva, Caio Patrício de Souza Sena, Davi Serradella Vieira, Magdi E. A. Zaki, Leow Chiuan Yee, Shahina Akter, Umberto Laino Fulco, Jonas Ivan Nobre Oliveira, João Firmino Rodrigues‐Neto   +8 more
wiley   +1 more source

Immunoinformatics and epitope prediction in the age of genomic medicine

, 2015
Immunoinformatics involves the application of computational methods to immunological problems. Prediction of B- and T-cell epitopes has long been the focus of immunoinformatics, given the potential translational implications, and many tools have been ...
Kohlbacher, O., Backert, L., Oliver Kohlbacher, Linus Backert   +3 more
core   +1 more source

Immunoinformatics Patterns and Characteristic of Epitope-Based Peptide Vaccine candidates against COVID-19 [PDF]

, 2020
Vaccination as defined by the WHO is “the administration of agent-specific, but safe, antigenic components that in vaccinated individuals can induce protective immunity against the corresponding infectious agent”. Regardless of their debated history, the
M. Makhawi, Abdelrafie, I. Mustafa, Mujahed, H. Abdelmoneim, Abdelrahman   +2 more
core   +1 more source