Results 41 to 50 of about 7,150 (221)

Conventional and regulatory CD4+ T cells that share identical TCRs are derived from common clones [PDF]

, 2016
Results from studies comparing the diversity and specificity of the TCR repertoires expressed by conventional (Tconv) and regulatory (Treg) CD4+ T cell have varied depending on the experimental system employed.
Buller, R. Mark, DiPaolo, Richard, Emerson, Ryan O, Pingel, Jeanette, Wolf, Kyle J   +4 more
core   +6 more sources

Deep Learning‐Enabled Engineering of a Hyper‐Stable and Soluble MPB70‐83 Antigen for Sensitive Bovine Tuberculosis Surveillance

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
Schematic representation of the research workflow for the efficient diagnosis of bovine tuberculosis employing peptide fusion proteins. ABSTRACT Bovine tuberculosis (bTB) diagnostics are frequently hindered by the structural instability and insolubility of recombinant multi‐epitope proteins in prokaryotic expression systems.
Wen‐Hao Wang, Jia‐Zhen Ge, Ying‐Ying Xie, Guo‐Dong Song, Yijian Liu, Yin‐juan Song, Ren‐ge Li, Rui‐Shuang Li, Zi‐qing Wang, Xin‐Miao Liu, Shuang‐Shuang Guo, Jie Li, Shengli Chen, Na Li, Fuying Zheng, Yuefeng Chu   +15 more
wiley   +1 more source

An In Silico Omics Investigation of the Lactobacillus Genus Complex for Allergenicity Mitigation

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
This graphical abstract illustrates the most promising Lactobacillus species for reducing allergenicity through an omics approach, integrating genomics and proteomics studies. Also, provides a clear overview of candidate strains that could be effectively utilized in mitigating allergic reactions.
Zahra Bigdeli, Ali Molaei, Nassim Rahmani, Zakie Mazhary, Najaf Allahyari Fard   +4 more
wiley   +1 more source

Integrated Functional and scRNA-Seq Analyses Reveal Convergence of M-CSF– and GM-CSF–Derived Macrophages Following IL-27 Polarization

Cells
Macrophages differentiated with macrophage colony-stimulating factor (M-CSF) (M-Mac) are widely used as an experimental model. Interleukin 27 (IL-27)-polarized M-Mac (27M-Mac) suppresses HIV replication; however, the effects of IL-27 polarization on ...
Tomozumi Imamichi, Jun Yang, Qian Chen, Udeshika Kariyawasam, Mayra Marquez, Jeanette Higgins, Jordan Metz, Homa Nath Sharma, Michael W. Baseler, Hongyan Sui   +9 more
doaj   +1 more source

Computational Validation of Multi‐Epitope mRNA Vaccine Targeting Streptococcus anginosus Surface Protein (TMPC) as an Effective Alternative Treatment to Reduce Gastric Cancer

MicrobiologyOpen, Volume 15, Issue 1, February 2026.
Design process for messenger RNA vaccines. Candidate proteins are initially screened using immunoinformatics, after which selected epitopes are assembled into a multi‐epitope vaccine. The vaccine construct was evaluated through molecular docking, molecular dynamics simulations, and in silico immune simulations, followed by population coverage analysis ...
Fei Zhu, Yuying Luo, Ziyou Zhou, Rongliu Qin, Shiyang Ma, Yizhong Xu, Jie Chen, Pinhua Pan   +7 more
wiley   +1 more source

A Biologically Informed Vision‐Guided Framework for Interpretable T Cell Receptor–Epitope Binding Prediction

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Integrating hierarchical physicochemical features via a bio‐inspired design, the DAISY framework robustly predicts T‐cell receptor binding, significantly outperforming state‐of‐the‐art models on unseen epitopes. It uniquely offers visual interpretability via Score‐CAM visualizations and profound clinical relevance, correlating with T‐cell expansion ...
Yajing Yuan, Junwei Chen, Yufang Zhang, Yitian Fang, Zhongcheng Fang, Yanyi Chu, Jiayi Li, Chen Zhang, Yuzhe Li, Dongqing Wei   +9 more
wiley   +1 more source

CelltrackR: An R package for fast and flexible analysis of immune cell migration data

ImmunoInformatics, 2021
Visualization of cell migration via time-lapse microscopy has greatly advanced our understanding of the immune system. However, subtle differences in migration dynamics are easily obscured by biases and imaging artifacts.
Inge M.N. Wortel, Annie Y. Liu, Katharina Dannenberg, Jeffrey C. Berry, Mark J. Miller, Johannes Textor   +5 more
doaj   +1 more source

FRED 2: an immunoinformatics framework for Python [PDF]

Bioinformatics, 2016
Abstract Summary: Immunoinformatics approaches are widely used in a variety of applications from basic immunological to applied biomedical research. Complex data integration is inevitable in immunological research and usually requires comprehensive pipelines including multiple tools and data sources. Non-standard input and output formats
Schubert, Benjamin, Walzer, Mathias, Brachvogel, Hans-Philipp, Szolek, András, Mohr, Christopher, Kohlbacher, Oliver   +5 more
openaire   +3 more sources

Deep learning for the detection of microsatellite instability from histology images in colorectal cancer: A systematic literature review

ImmunoInformatics, 2021
Microsatellite instability (MSI) or deficient mismatch repair (dMMR) is a clinically important genetic feature affecting 10–15% of colorectal cancer (CRC) patients.
Amelie Echle, Narmin Ghaffari Laleh, Peter L. Schrammen, Nicholas P. West, Christian Trautwein, Titus J. Brinker, Stephen B. Gruber, Roman D. Buelow, Peter Boor, Heike I. Grabsch, Philip Quirke, Jakob N. Kather   +11 more
doaj   +1 more source

Human IgG2- and IgG4-expressing memory B cells display enhanced molecular and phenotypic signs of maturity and accumulate with age [PDF]

, 2017
The mechanisms involved in sequential immunoglobulin G (IgG) class switching are still largely unknown. Sequential IG class switching is linked to higher levels of somatic hypermutation (SHM) in vivo, but it remains unclear if these are generated ...
Britt G Jong, Bruno G Loos, Hanna IJspeert, Jacques JM Dongen, Lemelinda Marques, Menno C Zelm, Mirjam Burg, Zhang K   +7 more
core   +2 more sources