Results 41 to 50 of about 4,043 (182)

Immunoinformatic Analysis of Human Thyroglobulin [PDF]

Cybernetics and Information Technologies, 2020
Abstract The AutoImmune ThyroiDitis (AITD), known as Hashimoto’s disease, is a chronic autoimmune thyroid disease progressively developed to hypothyroidism. The AITD is characterized by the formation of autoantibodies targeting two specific thyroid antigens, Thyroglobulin (Tg) and Thyroid PerOxidase (TPO).
Doytchinova Irini, Tchorbanov Andrey, Ivanov Stefan   +2 more
openaire   +2 more sources

Deep Learning‐Enabled Engineering of a Hyper‐Stable and Soluble MPB70‐83 Antigen for Sensitive Bovine Tuberculosis Surveillance

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
Schematic representation of the research workflow for the efficient diagnosis of bovine tuberculosis employing peptide fusion proteins. ABSTRACT Bovine tuberculosis (bTB) diagnostics are frequently hindered by the structural instability and insolubility of recombinant multi‐epitope proteins in prokaryotic expression systems.
Wen‐Hao Wang, Jia‐Zhen Ge, Ying‐Ying Xie, Guo‐Dong Song, Yijian Liu, Yin‐juan Song, Ren‐ge Li, Rui‐Shuang Li, Zi‐qing Wang, Xin‐Miao Liu, Shuang‐Shuang Guo, Jie Li, Shengli Chen, Na Li, Fuying Zheng, Yuefeng Chu   +15 more
wiley   +1 more source

Deep learning for the detection of microsatellite instability from histology images in colorectal cancer: A systematic literature review

ImmunoInformatics, 2021
Microsatellite instability (MSI) or deficient mismatch repair (dMMR) is a clinically important genetic feature affecting 10–15% of colorectal cancer (CRC) patients.
Amelie Echle, Narmin Ghaffari Laleh, Peter L. Schrammen, Nicholas P. West, Christian Trautwein, Titus J. Brinker, Stephen B. Gruber, Roman D. Buelow, Peter Boor, Heike I. Grabsch, Philip Quirke, Jakob N. Kather   +11 more
doaj   +1 more source

An In Silico Omics Investigation of the Lactobacillus Genus Complex for Allergenicity Mitigation

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
This graphical abstract illustrates the most promising Lactobacillus species for reducing allergenicity through an omics approach, integrating genomics and proteomics studies. Also, provides a clear overview of candidate strains that could be effectively utilized in mitigating allergic reactions.
Zahra Bigdeli, Ali Molaei, Nassim Rahmani, Zakie Mazhary, Najaf Allahyari Fard   +4 more
wiley   +1 more source

The effects of cryopreservation on PBMCs transcriptome profile

Frontiers in Immunology
Cryopreservation is a key method for long-term storage of biological specimens. The development of optimal cryopreservation and recovery conditions will minimize storage-related damage. The effect of the cryopreservation and recovery condition we used on
Xuan Li, Qian Chen, Jeanette Higgins, Kyndal Cook, Michael W. Baseler, Tomozumi Imamichi, Weizhong Chang   +6 more
doaj   +1 more source

Improving immunovirotherapies: the intersection of mathematical modelling and experiments

ImmunoInformatics, 2022
Combined oncolytic virotherapy and immunotherapy (immunovirotherapy) protocols represent a promising treatment strategy for a range of cancers and offer many advantages over conventional anti-cancer therapies.
Christine E. Engeland, Johannes P.W. Heidbuechel, Robyn P. Araujo, Adrianne L. Jenner   +3 more
doaj   +1 more source

Computational Validation of Multi‐Epitope mRNA Vaccine Targeting Streptococcus anginosus Surface Protein (TMPC) as an Effective Alternative Treatment to Reduce Gastric Cancer

MicrobiologyOpen, Volume 15, Issue 1, February 2026.
Design process for messenger RNA vaccines. Candidate proteins are initially screened using immunoinformatics, after which selected epitopes are assembled into a multi‐epitope vaccine. The vaccine construct was evaluated through molecular docking, molecular dynamics simulations, and in silico immune simulations, followed by population coverage analysis ...
Fei Zhu, Yuying Luo, Ziyou Zhou, Rongliu Qin, Shiyang Ma, Yizhong Xu, Jie Chen, Pinhua Pan   +7 more
wiley   +1 more source

A Biologically Informed Vision‐Guided Framework for Interpretable T Cell Receptor–Epitope Binding Prediction

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Integrating hierarchical physicochemical features via a bio‐inspired design, the DAISY framework robustly predicts T‐cell receptor binding, significantly outperforming state‐of‐the‐art models on unseen epitopes. It uniquely offers visual interpretability via Score‐CAM visualizations and profound clinical relevance, correlating with T‐cell expansion ...
Yajing Yuan, Junwei Chen, Yufang Zhang, Yitian Fang, Zhongcheng Fang, Yanyi Chu, Jiayi Li, Chen Zhang, Yuzhe Li, Dongqing Wei   +9 more
wiley   +1 more source

HIVGenoPipe: a nextflow pipeline for the detection of HIV-1 drug resistance using a real-time sample-specific reference sequence

BMC Bioinformatics
Background The emergence of HIV drug resistance is a challenge in controlling the acquired immunodeficiency syndrome (AIDS) pandemic caused by human immunodeficiency virus-1 (HIV-1) infection.
Thoai Dotrang, Brad T. Sherman, Lisheng Dai, Muhammad Ayub Khan, Helene C. Highbarger, Whitney Bruchey, Sylvain Laverdure, Michael W. Baseler, Tomozumi Imamichi, Robin L. Dewar, Weizhong Chang   +10 more
doaj   +1 more source

Immunotherapeutic Applications of Probiotics in Infectious Diseases Management: A Scoping Review

Advanced Gut &Microbiome Research, Volume 2026, Issue 1, 2026.
Probiotics are emerging as promising alternative therapies with diverse health applications, particularly in enhancing immunity and combating infectious diseases. This scoping review synthesizes evidence on the immunomodulatory and antimicrobial effects of well‐characterized strains, particularly species of Bifidobacterium and Lactobacillus. Probiotics
Samson Adedeji Adejumo, Chioma Miracle Ojiako, Pritha Das, Felix Chukwuebuka Onyia, Mavis Nkem Okafor, Ifeanyi Ferdinand Chukwuma, Jarrad Hampton-Marcell, Angus Nnamdi Oli, Jian Wu   +8 more
wiley   +1 more source