Results 41 to 50 of about 4,155 (183)

Designing a multi-epitope subunit vaccine against chikungunya virus using immunoinformatics and molecular simulation approaches

Scientific Reports
Chikungunya is a mosquito-borne viral illness that is responsible for increased rates of infection and major public health consequences, but no approved vaccine is available yet.
Sk.Faisal Ahmed, Amalesh Mondal, Abir Hossain, Md. Shah Paran, Kaniz Fatema, Shormila Akter Sumya, Taiyara Mahjabin, Abhishek Dadhich, Abhishek Kumar Verma   +8 more
doaj   +1 more source

Edible Insect Allergens: An Emerging Food Safety Challenge

Sustainable Food Proteins, Volume 4, Issue 3, September 2026.
Allergic responses to edible insects arise via two main pathways: cross‐reactivity with homologous arthropod allergens and primary sensitization to edible insect proteins, both leading to IgE‐mediated immune activation. ABSTRACT Edible insects are increasingly promoted as sustainable protein sources; however, their allergenic potential remains a ...
Changqi Liu, Cassandra Maya, John J. Love, Huilian Che, Ke Chen, Jing Zhao   +5 more
wiley   +1 more source

Decoding the Black Box of Fish Vaccines Efficacy in Basic and Applied Contexts

Reviews in Aquaculture, Volume 18, Issue 4, September 2026.
ABSTRACT Vaccines are the frontline defense in aquaculture, yet predicting their real‐world performance remains a tricky puzzle. Unlike terrestrial veterinary vaccines, fish vaccines largely operate through “Black Box” processes, where we observe the outcomes but rarely understand the underlying immune mechanisms. Laboratory trials, though informative,
Jiří Kyslík, Mikolaj Adamek, Tomáš Korytář   +2 more
wiley   +1 more source

Immunoinformatics and Vaccine Development: An Overview.

ImmunoTargets and therapy, 2020
The use of vaccines have resulted in a remarkable improvement in global health. It has saved several lives, reduced treatment costs and raised the quality of animal and human lives. Current traditional vaccines came empirically with either vague or completely no knowledge of how they modulate our immune system.
Oli,Angus Nnamdi, Obialor,Wilson Okechukwu, Ifeanyichukwu,Martins Ositadimma, Odimegwu,Damian Chukwu, Okoyeh,Jude Nnaemeka, Emechebe,George Ogonna, Adejumo,Samson Adedeji, Ibeanu,Gordon C   +7 more
openaire   +3 more sources

Integrated Functional and scRNA-Seq Analyses Reveal Convergence of M-CSF– and GM-CSF–Derived Macrophages Following IL-27 Polarization

Cells
Macrophages differentiated with macrophage colony-stimulating factor (M-CSF) (M-Mac) are widely used as an experimental model. Interleukin 27 (IL-27)-polarized M-Mac (27M-Mac) suppresses HIV replication; however, the effects of IL-27 polarization on ...
Tomozumi Imamichi, Jun Yang, Qian Chen, Udeshika Kariyawasam, Mayra Marquez, Jeanette Higgins, Jordan Metz, Homa Nath Sharma, Michael W. Baseler, Hongyan Sui   +9 more
doaj   +1 more source

Counteracting Influenza Virus Evolution Through the Full Spectrum of Broadly Protective Antibodies

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Despite the presence of licensed vaccines and therapeutics, influenza viruses remain a major public health concern, as they cause seasonal respiratory infections and pose a pandemic threat through the emergence of zoonotic strains. Although neutralizing antibodies elicited by seasonal vaccination constitute a primary defense against infection,
Yu Adachi, Yoshimasa Takahashi
wiley   +1 more source

IMGT-ONTOLOGY for immunogenetics and immunoinformatics.

In silico biology, 2003
IMGT, the international ImMunoGeneTics information system(R) (http://imgt.cines.fr), is a high quality integrated knowledge resource specializing in immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrates, created in 1989, by the Laboratoire d ...
Lefranc, Marie-Paule, Giudicelli, Véronique, Ginestoux, Chantal, Bosc, Nathalie, Folch, Géraldine, Guiraudou, Delphine, Jabado-Michaloud, Joumana, Magris, Séverine, Scaviner, Dominique, Thouvenin, Valérie, Combres, Kora, Girod, David, Jeanjean, Stéphanie, Protat, Céline, Yousfi-Monod, Mehdi, Duprat, Elodie, Kaas, Quentin, Pommié, Christelle, Chaume, Denys, Lefranc, Gérard   +19 more
openaire   +6 more sources

Safety and immunogenicity of an adjuvanted human onchocerciasis vaccine candidate, OvMANE1: preclinical evaluation in a mice model

Clinical &Translational Immunology, Volume 15, Issue 7, 2026.
OvMANE1 formulated with Freund's adjuvant was safe and elicited strong humoral and cellular immune responses, including significant IgG and leukocyte activation. These findings highlight OvMANE1 as a promising multi‐epitope vaccine candidate for advancing onchocerciasis prevention.
Derrick Neba Nebangwa, Mary Teke Efeti, Sonia M. E. Momnougui, Cabirou Mounchili Shintouo, Robert Adamu Shey, Rene Bilingwe Ayiseh, Fidele Ntie‐Kang, Stephen Mbigha Ghogomu   +7 more
wiley   +1 more source

CelltrackR: An R package for fast and flexible analysis of immune cell migration data

ImmunoInformatics, 2021
Visualization of cell migration via time-lapse microscopy has greatly advanced our understanding of the immune system. However, subtle differences in migration dynamics are easily obscured by biases and imaging artifacts.
Inge M.N. Wortel, Annie Y. Liu, Katharina Dannenberg, Jeffrey C. Berry, Mark J. Miller, Johannes Textor   +5 more
doaj   +1 more source

Chandipura Virus: An Emerging Neurological Threat Transmitted by Sandflies in India

Immunity, Inflammation and Disease, Volume 14, Issue 7, July 2026.
Chandipura virus (CHPV), a neurotropic arbovirus transmitted primarily by sandflies, has emerged as a significant public health concern in India following recurrent outbreaks with high pediatric fatality rates. This review highlights the virus's virology, transmission dynamics, clinical features, and the urgent need for improved diagnostics ...
Abrar Ahmad Zargar, Reena Gupta, P. Krishnamoorthy   +2 more
wiley   +1 more source