Results 51 to 60 of about 7,150 (221)

Synthesis of Chirally Chimeric Protein Nanoparticle Vaccines via Mirror‐Image Spy Chemistry

Angewandte Chemie, Volume 137, Issue 34, August 18, 2025.
This study illustrates a versatile strategy for creating chirally chimeric protein constructs by merging natural‐chirality (L‐) and mirror‐image (D‐) protein motifs through a combination of L‐sortase‐mediated transpeptidation and D‐SpyStapler‐mediated ligation.
Songzi Kou, Chenbo Sun, Weitao Chen, Hanyu Gao, Fei Sun   +4 more
wiley   +2 more sources

The effects of cryopreservation on PBMCs transcriptome profile

Frontiers in Immunology
Cryopreservation is a key method for long-term storage of biological specimens. The development of optimal cryopreservation and recovery conditions will minimize storage-related damage. The effect of the cryopreservation and recovery condition we used on
Xuan Li, Qian Chen, Jeanette Higgins, Kyndal Cook, Michael W. Baseler, Tomozumi Imamichi, Weizhong Chang   +6 more
doaj   +1 more source

Improving immunovirotherapies: the intersection of mathematical modelling and experiments

ImmunoInformatics, 2022
Combined oncolytic virotherapy and immunotherapy (immunovirotherapy) protocols represent a promising treatment strategy for a range of cancers and offer many advantages over conventional anti-cancer therapies.
Christine E. Engeland, Johannes P.W. Heidbuechel, Robyn P. Araujo, Adrianne L. Jenner   +3 more
doaj   +1 more source

Immunotherapeutic Applications of Probiotics in Infectious Diseases Management: A Scoping Review

Advanced Gut &Microbiome Research, Volume 2026, Issue 1, 2026.
Probiotics are emerging as promising alternative therapies with diverse health applications, particularly in enhancing immunity and combating infectious diseases. This scoping review synthesizes evidence on the immunomodulatory and antimicrobial effects of well‐characterized strains, particularly species of Bifidobacterium and Lactobacillus. Probiotics
Samson Adedeji Adejumo, Chioma Miracle Ojiako, Pritha Das, Felix Chukwuebuka Onyia, Mavis Nkem Okafor, Ifeanyi Ferdinand Chukwuma, Jarrad Hampton-Marcell, Angus Nnamdi Oli, Jian Wu   +8 more
wiley   +1 more source

Fragment Templates in Molecularly Imprinted Polymer Synthesis: Design Strategies, Critical Factors, and Analytical Applications

Advances in Materials Science and Engineering, Volume 2026, Issue 1, 2026.
The utilization of fragment templates in molecular imprinting polymer (MIP) synthesis attracts significant interest in its potential to create polymers with high specificity in recognizing target molecules. The primary advantage of fragment templates lies in their capacity to extract target molecules by focusing on specific components, thus forming ...
Ezra Calista Hutapea, Diva Dhaifina Mazaya Priana, Driyanti Rahayu, Aliya Nur Hasanah, Mohammad Rezwan Habib   +4 more
wiley   +1 more source

Structural Characterization and Functional Annotation of Hypothetical Proteins in the Multidrug‐Resistant Strains of Pseudomonas aeruginosa

BioMed Research International, Volume 2026, Issue 1, 2026.
Introduction Pseudomonas aeruginosa is a leading cause of severe nosocomial infections worldwide. This opportunistic pathogen is associated with increased morbidity and mortality rates due to its high levels of antibiotic resistance. The identification of novel therapeutic targets is therefore a pressing global health priority.
Fatemeh Nasiri Khoonsari, Zahra Zafari, Bufu Tang   +2 more
wiley   +1 more source

HIVGenoPipe: a nextflow pipeline for the detection of HIV-1 drug resistance using a real-time sample-specific reference sequence

BMC Bioinformatics
Background The emergence of HIV drug resistance is a challenge in controlling the acquired immunodeficiency syndrome (AIDS) pandemic caused by human immunodeficiency virus-1 (HIV-1) infection.
Thoai Dotrang, Brad T. Sherman, Lisheng Dai, Muhammad Ayub Khan, Helene C. Highbarger, Whitney Bruchey, Sylvain Laverdure, Michael W. Baseler, Tomozumi Imamichi, Robin L. Dewar, Weizhong Chang   +10 more
doaj   +1 more source

Epitopedia: identifying molecular mimicry between pathogens and known immune epitopes

ImmunoInformatics, 2023
Upon infection, foreign antigenic proteins stimulate the host's immune system to produce antibodies targeting the pathogen. These antibodies bind to regions on the antigen called epitopes.
Christian A Balbin, Janelle Nunez-Castilla, Vitalii Stebliankin, Prabin Baral, Masrur Sobhan, Trevor Cickovski, Ananda Mohan Mondal, Giri Narasimhan, Prem Chapagain, Kalai Mathee, Jessica Siltberg-Liberles   +10 more
doaj   +1 more source

Prediction of conformational B-cell epitopes from 3D structures by random forests with a distance-based feature [PDF]

, 2011
Background Antigen-antibody interactions are key events in immune system, which provide important clues to the immune processes and responses. In Antigen-antibody interactions, the specific sites on the antigens that are directly bound by the B-cell ...
Wen Zhang, Yi Xiong, Meng Zhao, Hua Zou, Xinghuo Ye, Juan Liu   +5 more
core   +2 more sources

Design of B‐Cell Multi‐Epitope Subunit Vaccines Against Glaesserella parasuis by Reverse Vaccinology: An In Silico and In Vivo Study

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Glässer’s disease caused by Glaesserella parasuis (GPS) is a severe disease that results in substantial economic losses to the swine industry worldwide. Here we describe a multiepitope vaccine cocktail (MEVC) that was designed using reverse vaccinology and immunoinformatics. The MEVC was comprised of three multiepitope subunits (MESs, designated as TB,
Yan Gong, Na Li, Ziheng Li, He Wang, Di Zhang, Hong Chu, Zhichao Lu, Aiqing Jia, Fengyang Li, Liancheng Lei, Zhong Peng   +10 more
wiley   +1 more source