Results 51 to 60 of about 4,043 (182)

A comparison of clustering models for inference of T cell receptor antigen specificity

ImmunoInformatics
The vast potential sequence diversity of TCRs and their ligands has presented an historic barrier to computational prediction of TCR epitope specificity, a holy grail of quantitative immunology.
Dan Hudson, Alex Lubbock, Mark Basham, Hashem Koohy   +3 more
doaj   +1 more source

Fragment Templates in Molecularly Imprinted Polymer Synthesis: Design Strategies, Critical Factors, and Analytical Applications

Advances in Materials Science and Engineering, Volume 2026, Issue 1, 2026.
The utilization of fragment templates in molecular imprinting polymer (MIP) synthesis attracts significant interest in its potential to create polymers with high specificity in recognizing target molecules. The primary advantage of fragment templates lies in their capacity to extract target molecules by focusing on specific components, thus forming ...
Ezra Calista Hutapea, Diva Dhaifina Mazaya Priana, Driyanti Rahayu, Aliya Nur Hasanah, Mohammad Rezwan Habib   +4 more
wiley   +1 more source

SARS-CoV-2-identical protein regions found in mammalian coronaviruses have immunogenic potential and can imply cross-protection

ImmunoInformatics
Coronaviruses are known to infect a wide range of mammals. In humans, coronaviruses have been responsible for causing the common cold. The immune response against common cold coronaviruses appears to elicit a cross-protective response to SARS-CoV-2. This
Luciano Rodrigo Lopes
doaj   +1 more source

Structural Characterization and Functional Annotation of Hypothetical Proteins in the Multidrug‐Resistant Strains of Pseudomonas aeruginosa

BioMed Research International, Volume 2026, Issue 1, 2026.
Introduction Pseudomonas aeruginosa is a leading cause of severe nosocomial infections worldwide. This opportunistic pathogen is associated with increased morbidity and mortality rates due to its high levels of antibiotic resistance. The identification of novel therapeutic targets is therefore a pressing global health priority.
Fatemeh Nasiri Khoonsari, Zahra Zafari, Bufu Tang   +2 more
wiley   +1 more source

Guiding a language-model based protein design method towards MHC Class-I immune-visibility targets in vaccines and therapeutics

ImmunoInformatics
Proteins have an arsenal of medical applications that include disrupting protein interactions, acting as potent vaccines, and replacing genetically deficient proteins.
Hans-Christof Gasser, Diego A. Oyarzún, Ajitha Rajan, Javier Antonio Alfaro   +3 more
doaj   +1 more source

Design of B‐Cell Multi‐Epitope Subunit Vaccines Against Glaesserella parasuis by Reverse Vaccinology: An In Silico and In Vivo Study

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Glässer’s disease caused by Glaesserella parasuis (GPS) is a severe disease that results in substantial economic losses to the swine industry worldwide. Here we describe a multiepitope vaccine cocktail (MEVC) that was designed using reverse vaccinology and immunoinformatics. The MEVC was comprised of three multiepitope subunits (MESs, designated as TB,
Yan Gong, Na Li, Ziheng Li, He Wang, Di Zhang, Hong Chu, Zhichao Lu, Aiqing Jia, Fengyang Li, Liancheng Lei, Zhong Peng   +10 more
wiley   +1 more source

ImmunoInformatics: at the crossroads between immunology and informatics, and beyond

ImmunoInformatics, 2021
Niels Halama, Doron Levy
doaj   +1 more source

Preclinical Evaluation of a Phage T4‐Based Multi‐Epitope Nanoparticle Vaccine Against Porcine Epidemic Diarrhea Virus

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Porcine epidemic diarrhea virus (PEDV) continues to threaten the global swine industry, and currently available vaccines often provide incomplete protection against emerging virulent strains. In this study, we developed a phage T4‐based multi‐epitope nanoparticle vaccine targeting PEDV. B and T cell epitopes derived from the PEDV spike (S) protein were
GuoQing Zhao, ShiDan Zhang, YuMin Zhang, ShengJing Jiao, XiaoYan Zeng, LuRu Zhao, Jie Wang, JingJiao Ma, YuQiang Cheng, HengAn Wang, YaXian Yan, JianHe Sun, ZhaoFei Wang, Nan-hua Chen   +13 more
wiley   +1 more source

A Serum‐Stable Antimicrobial Peptide‐Based Delivery Platform for Selective Treatment of Nontargetable and Chemoresistant Tumors

Advanced Science, Volume 12, Issue 45, December 4, 2025.
A modular antimicrobial‐peptide‐based therapeutic system integrating membrane‐targeted selectivity, a conformation‐driven polyethylene glycolylated blocker, and serum‐stabilizing N‐cap is developed. The optimized conjugate 270 shows potent, rapid killing of the desired tumor cells, high serum stability, low off‐target toxicity, and broad applicability,
Tianxing Liu, Lingyu Ke, Ruize Sun, Xiaoling Chen, Mei Zhou, Olaf R. P. Bininda‐Emond, Chengbang Ma, Yangyang Jiang, Tao Wang, Chris Shaw, Lei Wang, Tianbao Chen, Alideertu Dong   +12 more
wiley   +1 more source

mRNA Cancer Vaccines: From Pandemic Paradigm to Personalized Oncology Therapeutics

Cancer Innovation, Volume 4, Issue 6, December 2025.
This review highlights the transformative potential of mRNA cancer vaccines, leveraging technological advancements in nucleotide modification, lipid nanoparticle delivery, and AI‐driven neoantigen selection to enhance vaccine stability, immunogenicity, and personalization.
Bo Yang, Juan Liu, Yang Li, Xiaoxuan Liu
wiley   +1 more source