Results 51 to 60 of about 2,776 (178)

Designing a multi-epitope subunit vaccine against chikungunya virus using immunoinformatics and molecular simulation approaches

Scientific Reports
Chikungunya is a mosquito-borne viral illness that is responsible for increased rates of infection and major public health consequences, but no approved vaccine is available yet.
Sk.Faisal Ahmed, Amalesh Mondal, Abir Hossain, Md. Shah Paran, Kaniz Fatema, Shormila Akter Sumya, Taiyara Mahjabin, Abhishek Dadhich, Abhishek Kumar Verma   +8 more
doaj   +1 more source

Human Cytomegalovirus Genetic Diversity, Clinical Relevance, and Emerging Insights

Reviews in Medical Virology, Volume 36, Issue 5, September 2026.
ABSTRACT Human cytomegalovirus (HCMV) is a globally prevalent virus that poses a significant public health concern, especially for newborns and immunocompromised patients, causing a wide range of infections. Clinical outcomes associated with HCMV infection include congenital disease, graft rejection in transplant recipients, and life‐threatening ...
Hajar Y. AlQahtani, Fadilah Sfouq Aleanizy, Fulwah Yahya Alqahtani   +2 more
wiley   +1 more source

Image_1_Designing a multi-epitope vaccine against coxsackievirus B based on immunoinformatics approaches.jpg

, 2022
Coxsackievirus B (CVB) is one of the major viral pathogens of human myocarditis and cardiomyopathy without any effective preventive measures; therefore, it is necessary to develop a safe and efficacious vaccine against CVB.
Fengzhen Deng (14079264), Xinnan Hu (14079267), Yushu Deng (14079270), Wenran Zhao (6989219), Yanhang Wang (14079273), Congcong Zhang (334270), Zongmao Dai (14079261), Sichao Huang (4031558), Zhaohua Zhong (213963), Yuxuan Li (1674307), Jingjing Huang (170112), Yan Wang (15435), Xumeng Wang (12238019), Xinxin Yue (8628432), Jianing Li (359834)   +14 more
core   +1 more source

Edible Insect Allergens: An Emerging Food Safety Challenge

Sustainable Food Proteins, Volume 4, Issue 3, September 2026.
Allergic responses to edible insects arise via two main pathways: cross‐reactivity with homologous arthropod allergens and primary sensitization to edible insect proteins, both leading to IgE‐mediated immune activation. ABSTRACT Edible insects are increasingly promoted as sustainable protein sources; however, their allergenic potential remains a ...
Changqi Liu, Cassandra Maya, John J. Love, Huilian Che, Ke Chen, Jing Zhao   +5 more
wiley   +1 more source

Immunoinformatics and Vaccine Development: An Overview.

ImmunoTargets and therapy, 2020
The use of vaccines have resulted in a remarkable improvement in global health. It has saved several lives, reduced treatment costs and raised the quality of animal and human lives. Current traditional vaccines came empirically with either vague or completely no knowledge of how they modulate our immune system.
Oli,Angus Nnamdi, Obialor,Wilson Okechukwu, Ifeanyichukwu,Martins Ositadimma, Odimegwu,Damian Chukwu, Okoyeh,Jude Nnaemeka, Emechebe,George Ogonna, Adejumo,Samson Adedeji, Ibeanu,Gordon C   +7 more
openaire   +3 more sources

Integrated Functional and scRNA-Seq Analyses Reveal Convergence of M-CSF– and GM-CSF–Derived Macrophages Following IL-27 Polarization

Cells
Macrophages differentiated with macrophage colony-stimulating factor (M-CSF) (M-Mac) are widely used as an experimental model. Interleukin 27 (IL-27)-polarized M-Mac (27M-Mac) suppresses HIV replication; however, the effects of IL-27 polarization on ...
Tomozumi Imamichi, Jun Yang, Qian Chen, Udeshika Kariyawasam, Mayra Marquez, Jeanette Higgins, Jordan Metz, Homa Nath Sharma, Michael W. Baseler, Hongyan Sui   +9 more
doaj   +1 more source

Rpf‐Toxo: A Preliminary Computationally Designed Dense Granule Antigen‐Based Multi‐Epitope Vaccine Against Toxoplasma gondii

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
This graphical abstract summarizes the in silico design of the multi‐epitope vaccine candidate Rpf‐Toxo (Seq4) against Toxoplasma gondii. The workflow includes antigen selection, epitope mapping, vaccine construction, structural and immunological evaluation, toll‐like receptor‐4 docking, immune simulation, safety assessment, codon optimisation and ...
Mohamad Hosein Safari, Seyyed Amir Hosseini, Shadan Ghiabi, Shamim Ghiabi, Davood Siamian, Hamidreza Majidiani, Hamid Irannejad, Ali Asghari   +7 more
wiley   +1 more source

Image_2_Designing a multi-epitope vaccine against coxsackievirus B based on immunoinformatics approaches.jpeg

, 2022
Coxsackievirus B (CVB) is one of the major viral pathogens of human myocarditis and cardiomyopathy without any effective preventive measures; therefore, it is necessary to develop a safe and efficacious vaccine against CVB.
Fengzhen Deng (14079264), Xinnan Hu (14079267), Yushu Deng (14079270), Wenran Zhao (6989219), Yanhang Wang (14079273), Congcong Zhang (334270), Zongmao Dai (14079261), Sichao Huang (4031558), Zhaohua Zhong (213963), Yuxuan Li (1674307), Jingjing Huang (170112), Yan Wang (15435), Xumeng Wang (12238019), Xinxin Yue (8628432), Jianing Li (359834)   +14 more
core   +1 more source

Structural T‐Cell Receptor Analysis in the Age of Machine Learning

Immunological Reviews, Volume 342, Issue 1, September 2026.
ABSTRACT The development of highly accurate deep learning models for protein structure prediction has transformed the landscape of T‐cell receptor (TCR) structure data, which can now be accessed at repertoire scale. We provide a perspective on the growing field of structural TCR immunoinformatics, summarizing core principles of TCR structural biology ...
Nele P. Quast, Matthew I. J. Raybould, Charlotte M. Deane   +2 more
wiley   +1 more source

IMGT-ONTOLOGY for immunogenetics and immunoinformatics.

In silico biology, 2003
IMGT, the international ImMunoGeneTics information system(R) (http://imgt.cines.fr), is a high quality integrated knowledge resource specializing in immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrates, created in 1989, by the Laboratoire d ...
Lefranc, Marie-Paule, Giudicelli, Véronique, Ginestoux, Chantal, Bosc, Nathalie, Folch, Géraldine, Guiraudou, Delphine, Jabado-Michaloud, Joumana, Magris, Séverine, Scaviner, Dominique, Thouvenin, Valérie, Combres, Kora, Girod, David, Jeanjean, Stéphanie, Protat, Céline, Yousfi-Monod, Mehdi, Duprat, Elodie, Kaas, Quentin, Pommié, Christelle, Chaume, Denys, Lefranc, Gérard   +19 more
openaire   +6 more sources