Results 61 to 70 of about 2,776 (178)

Immunoinformatic Analysis of Human Thyroglobulin [PDF]

Cybernetics and Information Technologies, 2020
Abstract The AutoImmune ThyroiDitis (AITD), known as Hashimoto’s disease, is a chronic autoimmune thyroid disease progressively developed to hypothyroidism. The AITD is characterized by the formation of autoantibodies targeting two specific thyroid antigens, Thyroglobulin (Tg) and Thyroid PerOxidase (TPO).
Doytchinova Irini, Tchorbanov Andrey, Ivanov Stefan   +2 more
openaire   +2 more sources

CelltrackR: An R package for fast and flexible analysis of immune cell migration data

ImmunoInformatics, 2021
Visualization of cell migration via time-lapse microscopy has greatly advanced our understanding of the immune system. However, subtle differences in migration dynamics are easily obscured by biases and imaging artifacts.
Inge M.N. Wortel, Annie Y. Liu, Katharina Dannenberg, Jeffrey C. Berry, Mark J. Miller, Johannes Textor   +5 more
doaj   +1 more source

Decoding the Black Box of Fish Vaccines Efficacy in Basic and Applied Contexts

Reviews in Aquaculture, Volume 18, Issue 4, September 2026.
ABSTRACT Vaccines are the frontline defense in aquaculture, yet predicting their real‐world performance remains a tricky puzzle. Unlike terrestrial veterinary vaccines, fish vaccines largely operate through “Black Box” processes, where we observe the outcomes but rarely understand the underlying immune mechanisms. Laboratory trials, though informative,
Jiří Kyslík, Mikolaj Adamek, Tomáš Korytář   +2 more
wiley   +1 more source

A Comparison of Two Methods for T Cell Epitope Mapping: “Cell Free” In Vitro Versus Immunoinformatics [PDF]

, 2011
Background: Methods for identifying physiologically relevant T-cell epitopes are critically important for development of vaccines and the design of therapeutic proteins.
Martin, William, De Groot, Anne S., Messitt, Timothy J., Terry, Frances, Moise, Leonard   +4 more
core   +1 more source

Deep learning for the detection of microsatellite instability from histology images in colorectal cancer: A systematic literature review

ImmunoInformatics, 2021
Microsatellite instability (MSI) or deficient mismatch repair (dMMR) is a clinically important genetic feature affecting 10–15% of colorectal cancer (CRC) patients.
Amelie Echle, Narmin Ghaffari Laleh, Peter L. Schrammen, Nicholas P. West, Christian Trautwein, Titus J. Brinker, Stephen B. Gruber, Roman D. Buelow, Peter Boor, Heike I. Grabsch, Philip Quirke, Jakob N. Kather   +11 more
doaj   +1 more source

Immuno‐Informatics Design of Multi‐Epitope Vaccine Candidate Against Anaplasma phagocytophilum Using Major Surface Protein 4 (MSP‐4) Antigen

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims Bovine anaplasmosis is an intracellular tick‐borne, non‐contagious disease caused by gram‐negative bacteria of the family Anaplasmataceae and order Rickettsia. Anaplasma phagocytophilum is the etiological agent for human granulocytic anaplasmosis associated with severe health implications in parts of Europe and the USA and ...
Samson Anjikwi Malgwi, Sinalo Mani, Iliya Dauda Kwoji, Victoria T. Adeleke, Matthew A. Adeleke, Moses Okpeku   +5 more
wiley   +1 more source

Image_5_Designing a multi-epitope vaccine against coxsackievirus B based on immunoinformatics approaches.jpeg

, 2022
Coxsackievirus B (CVB) is one of the major viral pathogens of human myocarditis and cardiomyopathy without any effective preventive measures; therefore, it is necessary to develop a safe and efficacious vaccine against CVB.
Fengzhen Deng (14079264), Xinnan Hu (14079267), Yushu Deng (14079270), Wenran Zhao (6989219), Yanhang Wang (14079273), Congcong Zhang (334270), Zongmao Dai (14079261), Sichao Huang (4031558), Zhaohua Zhong (213963), Yuxuan Li (1674307), Jingjing Huang (170112), Yan Wang (15435), Xumeng Wang (12238019), Xinxin Yue (8628432), Jianing Li (359834)   +14 more
core   +1 more source

The effects of cryopreservation on PBMCs transcriptome profile

Frontiers in Immunology
Cryopreservation is a key method for long-term storage of biological specimens. The development of optimal cryopreservation and recovery conditions will minimize storage-related damage. The effect of the cryopreservation and recovery condition we used on
Xuan Li, Qian Chen, Jeanette Higgins, Kyndal Cook, Michael W. Baseler, Tomozumi Imamichi, Weizhong Chang   +6 more
doaj   +1 more source

Improving immunovirotherapies: the intersection of mathematical modelling and experiments

ImmunoInformatics, 2022
Combined oncolytic virotherapy and immunotherapy (immunovirotherapy) protocols represent a promising treatment strategy for a range of cancers and offer many advantages over conventional anti-cancer therapies.
Christine E. Engeland, Johannes P.W. Heidbuechel, Robyn P. Araujo, Adrianne L. Jenner   +3 more
doaj   +1 more source

Counteracting Influenza Virus Evolution Through the Full Spectrum of Broadly Protective Antibodies

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Despite the presence of licensed vaccines and therapeutics, influenza viruses remain a major public health concern, as they cause seasonal respiratory infections and pose a pandemic threat through the emergence of zoonotic strains. Although neutralizing antibodies elicited by seasonal vaccination constitute a primary defense against infection,
Yu Adachi, Yoshimasa Takahashi
wiley   +1 more source