Results 61 to 70 of about 4,043 (182)
Veterinary Medicine and Science, Volume 11, Issue 6, November 2025.This study presents a comprehensive genomic and immunoinformatics analysis of a bovine‐derived Brucella abortus S19 field strain, revealing significant antigenic variations and virulence adaptations impacting vaccine efficacy. These findings provide insights for designing improved vaccines tailored to regional epidemiological needs.
Ali Arslan +3 more
wiley +1 more source
Navigating the immunosuppressive brain tumor microenvironment using spatial biology
ImmunoInformaticsWith the application of spatial biology, the detection and identification of the diverse cell types present in the tumor microenvironment, including specific immune subsets, is possible at single cell resolution.
Samuel S. Widodo +5 more
doaj +1 more source
Transfer learning improves pMHC kinetic stability and immunogenicity predictions
ImmunoInformaticsThe cellular immune response comprises several processes, with the most notable ones being the binding of the peptide to the Major Histocompability Complex (MHC), the peptide-MHC (pMHC) presentation to the surface of the cell, and the recognition of the ...
Romanos Fasoulis +4 more
doaj +1 more source
ImmunoInformaticsCD8 T cell proper differentiation during antiviral responses relies on metabolic adaptations. Herein, we investigated global metabolic activity in single CD8 T cells along an in vivo response by estimating metabolic fluxes from single-cell RNA-sequencing
Christophe Arpin +2 more
doaj +1 more source
Immunoinformatics: Current trends and future directions
Drug Discovery Today, 2009 Immunoinformatics has recently emerged as a critical field for accelerating immunology research. Although still an evolving process, computational models now play instrumental roles, not only in directing the selection of key experiments, but also in the formulation of new testable hypotheses through detailed analysis of complex immunologic data that ...
Tong, Joo Chuan, Ren, Ee Chee
openaire +2 more sources
Is the vaccination-induced B cell receptor repertoire predictable?
ImmunoInformaticsVaccines trigger an immune response that results in a population of memory cells that can quickly respond to subsequent antigen re-encounters. Most vaccines are designed to induce memory B cells with vaccine-specific B cell receptors (BCRs).
Eve Richardson +4 more
doaj +1 more source
Challenges for the immunoglobulin and T cell receptor gene nomenclatures in the modern genomics era
ImmunoInformaticsFor over thirty years, an approach to the nomenclatures of human immunoglobulin (IG) and T cell receptor (TR) genes has operated successfully and has been widely supported by the research community. The principles behind the human nomenclatures were then
Andrew M. Collins +5 more
doaj +1 more source
Immunoglobulins: 25 Years of Immunoinformatics and IMGT-ONTOLOGY [PDF]
Biomolecules, 2014 IMGT®, the international ImMunoGeneTics information system® (CNRS and Montpellier University) is the global reference in immunogenetics and immunoinformatics. By its creation in 1989, IMGT® marked the advent of immunoinformatics, which emerged at the interface between immunogenetics and bioinformatics.
openaire +3 more sources
Lessons learned from the IMMREP23 TCR-epitope prediction challenge
ImmunoInformaticsHere, we present the findings from IMMREP23, the second benchmark competition focused on predicting the specificity of TCR-pMHC interactions.The interaction of T cell receptors (TCR) towards their pMHC target is a cornerstone of the cellular immune ...
Morten Nielsen +16 more
doaj +1 more source
Data mining antibody sequences for database searching in bottom-up proteomics
ImmunoInformaticsMass spectrometry-based proteomics facilitates the identification and quantification of thousands of proteins but encounters challenges in measuring human antibodies due to their vast diversity.
Xuan-Tung Trinh +3 more
doaj +1 more source