Results 71 to 80 of about 7,150 (221)

Immunoinformatics‐Based Multi‐Epitope Vaccine Design Against P. falciparum‐Causing Malaria: A Computational Approach

Health Science Reports, Volume 8, Issue 10, October 2025.
ABSTRACT Background and Aim Malaria is an infectious disease that affects people in Africa, and other parts of the world by the millions. Despite the effectiveness of artemisinin‐based combination therapies against the disease, current findings on possible Plasmodium resistance to artemisinin warrants an exploration of new treatment options. This study
Amma Aboagyewa Larbi, Caleb Mensah, Rebecca Korankye, Andrew Appiah Darkwah, Esther Boakye Agyemang, Isaac Yao Ayikpah, Alexander Kwarteng   +6 more
wiley   +1 more source

Allergens derived from shrimp [PDF]

, 2015
Allergy caused by food is usually type 1 allergy of four types of allergic reactions. One of the most widespread allergic is those that are caused by crustacean shellfish. Crustaceans are classified among arthropods which include crab, crayfish, lobster,
Abdull Razis, Ahmad Faizal, Packiamuthu Dewaprigam Solomen, Mary Margaret, Selamat, Jinap   +2 more
core  

Automated benchmarking of peptide-MHC class I binding predictions [PDF]

, 2015
Motivation: Numerous in silico methods predicting peptide binding to major histocompatibility complex (MHC) class I molecules have been developed over the last decades. However, the multitude of available prediction tools makes it non-trivial for the end-
Greenbaum, Jason, Kim, Yohan, Lund, Ole, Metushi, Imir G., Nielsen, Morten, Peters, Bjoern, Sette, Alessandro, Sidney, John, Trolle, Thomas   +8 more
core   +3 more sources

A Mutation‐Based Reverse Vaccinology Approach Considering Variability in Epitopes to Combat Multi‐Strains: A Study Using Glycoprotein of LASV

Journal of Cellular and Molecular Medicine, Volume 29, Issue 20, October 2025.
ABSTRACT Lassa virus (LASV) remains a persistent threat to public health, and to combat this, various therapeutics have been developed, but their effectiveness is limited due to the virus's strain variability. Therefore, mutation‐based reverse vaccinology approaches were implemented to formulate an epitope‐based vaccine against the LASV, considering ...
Saurav Kumar Mishra, Rajesh B. Patil, Amdola Tshering Sherpa, Mohammad Borhan Uddin, Md. Harun‐Or‐Rashid, Muniruddin Ahmed, Turki M. Dawoud, John J. Georrge   +7 more
wiley   +1 more source

ImmunoInformatics: at the crossroads between immunology and informatics, and beyond

ImmunoInformatics, 2021
Niels Halama, Doron Levy
doaj   +1 more source

Allergenicity and oral tolerance of enzymatic cross-linked tropomyosin evaluated using cell and mouse models [PDF]

, 2017
The enzymatic cross-linking of proteins to form high-molecular-weight compounds may alter their sensitization potential. The IgG-/IgE-binding activity, digestibility, allergenicity, and oral tolerance of cross-linked tropomyosin with tyrosinase (CTC) or ...
Alcocer, Marcos J.C., Cao, Min-Jie, Fei, Dan-Xia, Han, Xin-Yu, Hu, Meng-Jun, Liu, Guang-Ming, Liu, Guang-Yu, Liu, Qing-Mei, Sun, Le-Chang   +8 more
core   +2 more sources

T‐cell receptor insights: Determinants of Major Histocompatibility Complex class I versus class II recognition

Protein Science, Volume 34, Issue 9, September 2025.
Abstract In this study, we analyzed large‐scale T‐cell receptor (TCR) sequence data to determine whether TCRs preferentially bind to major histocompatibility complex (MHC) class I (CD8+) or class II (CD4+) epitopes. Using the International ImMunoGeneTics information system numbering scheme, we identified specific positions with distinct amino acid ...
Marcus De Almeida Mendes, Leila Chihab, Jonas Birkelund Nilsson, Lonneke Scheffer, Morten Nielsen, Bjoern Peters   +5 more
wiley   +1 more source

Survival analysis of DNA mutation motifs with penalized proportional hazards

, 2018
Antibodies, an essential part of our immune system, develop through an intricate process to bind a wide array of pathogens. This process involves randomly mutating DNA sequences encoding these antibodies to find variants with improved binding, though ...
Feng, Jean, Matsen IV, Frederick A., Minin, Vladimir N., Shaw, David A., Simon, Noah   +4 more
core   +2 more sources

IMGT-ONTOLOGY for immunogenetics and immunoinformatics.

In silico biology, 2004
IMGT, the international ImMunoGeneTics information system(R) (http://imgt.cines.fr), is a high quality integrated knowledge resource specializing in immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrates, created in 1989, by the Laboratoire d ...
Lefranc, Marie-Paule, Giudicelli, Véronique, Ginestoux, Chantal, Bosc, Nathalie, Folch, Géraldine, Guiraudou, Delphine, Jabado-Michaloud, Joumana, Magris, Séverine, Scaviner, Dominique, Thouvenin, Valérie, Combres, Kora, Girod, David, Jeanjean, Stéphanie, Protat, Céline, Yousfi-Monod, Mehdi, Duprat, Elodie, Kaas, Quentin, Pommié, Christelle, Chaume, Denys, Lefranc, Gérard   +19 more
openaire   +3 more sources

Immunoinformatics: Current trends and future directions

Drug Discovery Today, 2009
Immunoinformatics has recently emerged as a critical field for accelerating immunology research. Although still an evolving process, computational models now play instrumental roles, not only in directing the selection of key experiments, but also in the formulation of new testable hypotheses through detailed analysis of complex immunologic data that ...
Tong, J.C., Ren, E.C.
openaire   +2 more sources