Results 91 to 100 of about 2,776 (178)

Using Immunoinformatics to Design a mRNA Vaccine against the Spike Glycoprotein of SARS-CoV-2

, 2021
The rapid outbreak of the new coronavirus SARS-COV-2 has created a major public health challenge. Immunoinformatics tools had a clear effect in tracking the genetic sequence of the virus and monitoring mutations and design vaccines that are effective ...
Elkholy, Shereen F.
core   +1 more source

AMULETY: A Python package to embed adaptive immune receptor sequences

ImmunoInformatics
Large language models have been developed to capture relevant features of adaptive immune receptors, each with unique potential applications. However, the diversity in available models presents challenges in accessibility and usability for downstream ...
Meng Wang, Wengyao Jiang, Yuval Kluger, Steven H. Kleinstein, Gisela Gabernet   +4 more
doaj   +1 more source

Novel prophylactic and therapeutic multi-epitope vaccine based on Ag85A, Ag85B, ESAT-6, and CFP-10 of Mycobacterium tuberculosis using an immunoinformatics approach [PDF]

Objectives Current tuberculosis (TB) control strategies face limitations, such as low antibiotic treatment compliance and a rise in multidrug resistance. Furthermore, the lack of a safe and effective vaccine compounds these challenges.
Tasya Salsabila, Sari Eka Pratiwi, Ysrafil Ysrafil, Arsila Nurizati, Daniel Alexander Changestu, Rizky Ramadhan, Muhammad Fikri Nugraha   +6 more
core   +2 more sources

A comparison of clustering models for inference of T cell receptor antigen specificity

ImmunoInformatics
The vast potential sequence diversity of TCRs and their ligands has presented an historic barrier to computational prediction of TCR epitope specificity, a holy grail of quantitative immunology.
Dan Hudson, Alex Lubbock, Mark Basham, Hashem Koohy   +3 more
doaj   +1 more source

Immunoinformatics: Current trends and future directions

Drug Discovery Today, 2009
Immunoinformatics has recently emerged as a critical field for accelerating immunology research. Although still an evolving process, computational models now play instrumental roles, not only in directing the selection of key experiments, but also in the formulation of new testable hypotheses through detailed analysis of complex immunologic data that ...
Tong, Joo Chuan, Ren, Ee Chee
openaire   +2 more sources

SARS-CoV-2-identical protein regions found in mammalian coronaviruses have immunogenic potential and can imply cross-protection

ImmunoInformatics
Coronaviruses are known to infect a wide range of mammals. In humans, coronaviruses have been responsible for causing the common cold. The immune response against common cold coronaviruses appears to elicit a cross-protective response to SARS-CoV-2. This
Luciano Rodrigo Lopes
doaj   +1 more source

Epitope Prediction by Novel Immunoinformatics Approach: A State-of-the-art Review [PDF]

, 2020
Immunoinformatics is a science that helps to create significant immunological information using bioinformatics softwares and applications. One of the most important applications of immunoinformatics is the prediction of a variety of specific epitopes for
Eftekhari, S., Hemmati, M., Mohsenzadegan, M., Khaksaran, K., Mahmodi, Z., Farajollahi, M.M., Raoufi, E.   +6 more
core  

Guiding a language-model based protein design method towards MHC Class-I immune-visibility targets in vaccines and therapeutics

ImmunoInformatics
Proteins have an arsenal of medical applications that include disrupting protein interactions, acting as potent vaccines, and replacing genetically deficient proteins.
Hans-Christof Gasser, Diego A. Oyarzún, Ajitha Rajan, Javier Antonio Alfaro   +3 more
doaj   +1 more source

Integrating Metagenomics and Immunoinformatics to Prioritize Antigens and Immune-Modulating Molecules from Environmental Microbiomes

Environmental microbiomes - especially diverse soil and terrestrial communities - harbor an immense and largely untapped reservoir of microbial genetic diversity.
Harsh Purohit, Jignesh Kamdar
core   +1 more source

Navigating the immunosuppressive brain tumor microenvironment using spatial biology

ImmunoInformatics
With the application of spatial biology, the detection and identification of the diverse cell types present in the tumor microenvironment, including specific immune subsets, is possible at single cell resolution.
Samuel S. Widodo, Marija Dinevska, Stanley S. Stylli, Adriano L. Martinelli, Marianna Rapsomaniki, Theo Mantamadiotis   +5 more
doaj   +1 more source