Results 101 to 110 of about 7,150 (221)

Looming REF deadlines lead to a rush in publication of lower quality research [PDF]

, 2018
The increased significance of research assessments and their implications for funding and career prospects has had a knock-on effect on academic publication patterns. Moqi Groen-Xu, Pedro A.
Groen-Xu, Moqi, Knapp, Bernhard, Teixeira, Pedro, Voigt, Thomas   +3 more
core  

Comparison of different substitution matrices for distance based T-cell receptor epitope predictions using tcrdist3

ImmunoInformatics
Various methods, differing in complexity, have been developed to predict T-cell receptor epitopes. tcrdist3, which implements an easy-to-interpret distance-based approach, has demonstrated performance comparable to the best feature-based methods. Here, a
Marc Hoffstedt, Hermann Wätzig, Knut Baumann   +2 more
doaj   +1 more source

AnalyzAIRR: A user-friendly guided workflow for AIRR data analysis

ImmunoInformatics
The analysis of bulk adaptive immune receptor repertoires (AIRR) enables the understanding of immune responses in both normal and pathological conditions.
Vanessa Mhanna, Gabriel Pires, Grégoire Bohl-Viallefond, Karim El Soufi, Nicolas Tchitchek, David Klatzmann, Adrien Six, Hang P. Pham, Encarnita Mariotti-Ferrandiz   +8 more
doaj   +1 more source

AMULETY: A Python package to embed adaptive immune receptor sequences

ImmunoInformatics
Large language models have been developed to capture relevant features of adaptive immune receptors, each with unique potential applications. However, the diversity in available models presents challenges in accessibility and usability for downstream ...
Meng Wang, Wengyao Jiang, Yuval Kluger, Steven H. Kleinstein, Gisela Gabernet   +4 more
doaj   +1 more source

Immunoinformatics: Implications on Reverse Vaccinology

Immunochemistry & Immunopathology, 2017
One area in which immunological studies have had most immediate and successful application is in the field of vaccination. Vaccines represent one of the greatest interventions in modern medicine [1]. Ever since Edward Jenner’s first use of a vaccine against smallpox in 1796, the use of vaccines has become indispensable to the eradication of disease [2].
openaire   +1 more source

Structural insights on the differentiation and reversion of conformational changes in SARS-CoV-2 spike protein models across variants occurring from December, 2019 to November, 2021

ImmunoInformatics
Conformational changes in the SARS-CoV-2 spike protein are critical for understanding viral evolution. In this study, we provide comparative structural and electrostatic analyses across variants, revealing both differentiation and reversion patterns not ...
Marni E. Cueno, Kenichi Imai
doaj   +1 more source

Building immunoglobulin and T cell receptor gene databases for the future

ImmunoInformatics
Genetic databases for immunoglobulin (IG) and T cell receptor (TR) genes have evolved from small catalogs to critical resources underpinning immunogenetic research.
Corey T. Watson, Andrew M. Collins, Mats Ohlin, James M. Heather, Ayelet Peres, William D. Lees, Gur Yaari   +6 more
doaj   +1 more source

Highly conserved regions in Ebola virus RNA dependent RNA polymerase may be act as a universal novel peptide vaccine target: a computational approach [PDF]

, 2015
Afrin Sultana Chowdhury, Arafat Rahman Oany, Md. Anayet Hasan, Tahmina Pervin Jyoti, Tahmina Sharmin   +4 more
core   +1 more source

Machine learning in AIRR diagnostics: Advances and applications

ImmunoInformatics
Recent advancements in sequencing technologies have led to an exponential increase in adaptive immune receptor repertoire (AIRR) data. These receptors, crucial to the adaptive immune system, are believed to have strong potential for diagnostic ...
Aslı Semerci, Celine AlBalaa, Brian Corrie, Dylan Duchen, Gisela Gabernet, Jinwoo Leem, Enkelejda Miho, Ulrik Stervbo, Justin Barton, Pieter Meysman   +9 more
doaj   +1 more source

Development and validation of an epitope prediction tool for swine (PigMatrix) based on the pocket profile method [PDF]

, 2015

core   +1 more source