Results 1 to 10 of about 50,861 (164)

Learning from HIV-1 to predict the immunogenicity of T cell epitopes in SARS-CoV-2

iScience, 2021
Summary: We describe a physics-based learning model for predicting the immunogenicity of cytotoxic T lymphocyte (CTL) epitopes derived from diverse pathogens including SARS-CoV-2. The model was trained and optimized on the relative immunodominance of CTL
Ang Gao, Zhilin Chen, Assaf Amitai, Julia Doelger, Vamsee Mallajosyula, Emily Sundquist, Florencia Pereyra Segal, Mary Carrington, Mark M. Davis, Hendrik Streeck, Arup K. Chakraborty, Boris Julg   +11 more
doaj   +1 more source

Epitope-Based Vaccine Target Screening against Highly Pathogenic MERS-CoV: An In Silico Approach Applied to Emerging Infectious Diseases. [PDF]

PLoS ONE, 2015
Middle East respiratory syndrome coronavirus (MERS-CoV) with pandemic potential is a major worldwide threat to public health. However, vaccine development for this pathogen lags behind as immunity associated with protection is currently largely unknown ...
Jiandong Shi, Jing Zhang, Sijin Li, Jing Sun, Yumei Teng, Meini Wu, Jianfan Li, Yanhan Li, Ningzhu Hu, Haixuan Wang, Yunzhang Hu   +10 more
doaj   +1 more source

In silico design and immunoinformatics analysis of a universal multi-epitope vaccine against monkeypox virus

PLoS ONE, 2023
Monkeypox virus (MPXV) outbreaks have been reported in various countries worldwide; however, there is no specific vaccine against MPXV. In this study, therefore, we employed computational approaches to design a multi-epitope vaccine against MPXV ...
Samira Sanami, Shahin Nazarian, Sajjad Ahmad, Elham Raeisi, Muhammad Tahir ul Qamar, Shahram Tahmasebian, Hamidreza Pazoki-Toroudi, Maryam Fazeli, Mahdi Ghatreh Samani   +8 more
doaj   +2 more sources

Predicting potential epitopes of structural proteins for Alpha, Delta, and Omicron variants of SARS-CoV-2

Heliyon
Background: Due to the emergence of highly transmissible variants, such as the recombinant subvariant XEC, SARS-CoV-2 continues to spread worldwide. Epitope-based vaccines have been developed since conventional antigen-based vaccines may not provide ...
Diyantoro, Fedik Abdul Rantam, Juniastuti, Andi Yasmin Wijaya, Helen Susilowati, Suryo Kuncorojakti, Ahmad Aswin   +6 more
doaj   +1 more source

Designing a conjugate vaccine targeting Klebsiella pneumoniae ST258 and ST11

Heliyon
Klebsiella pneumoniae (K. pneumoniae) is a common bacterium that can cause iatrogenic infection. Recently, the rise of antibiotic resistance among K. pneumoniae strains is one key factor associated with antibiotic treatment failure.
Min Li, Mingkai Yu, Yigang Yuan, Danyang Li, Daijiao Ye, Min Zhao, Zihan Lin, Liuzhi Shi   +7 more
doaj   +1 more source

Screening helper T lymphocyte epitopes based on IFN-γ/IL-10 ratio for developing a novel multi-epitope vaccine candidate using Wolbachia surface protein as an adjuvant against visceral leishmaniasis

Parasites & Vectors
Background Visceral leishmaniasis (VL) is the most lethal form of leishmaniasis. In terms of anti-leishmanial vaccines, favorable immune responses are Th1 responses that primarily produce interferon gamma (IFN-γ) and activate macrophages for ...
Jianhui Zhang, Tianhang Lv, Shuoyan Tan, Lingqi Yu, Yangjian Chi, Jianping Chen, Xiaohui Fan, Xiaoyan Lu   +7 more
doaj   +1 more source

Immunogenicity of two FMDV nonameric peptides encapsulated in liposomes in mice and the protective efficacy in guinea pigs. [PDF]

PLoS ONE, 2013
It has been predicted that nonameric peptides I (VP1(26-34), RRQHTDVSF), II (VP1(157-165), RTLPTSFNY) and III (VP1(45-53), KEQVNVLDL) from the VP1 capsid protein of the foot-and-mouth disease virus (FMDV) are T cell epitopes. To investigate whether these
Feng-Shan Gao, Lei Feng, Qiang Zhang, Ruo-qian Yan, Yun-Gang Li, Xin-sheng Li   +5 more
doaj   +1 more source

Evaluation of a conserved glycoprotein precursor (GPC) derived, pan-Lassa fever T cell epitope-based vaccine candidate

The Microbe
Lassa fever (LF) is a viral zoonotic disease that can lead to fatal outcomes in some cases of human infection. Currently, no licensed vaccines are available to protect humans from this disease.
Rebecca Oziohu Omosimua, Srinivasan Prabhu, Baskar Venkidasamy, Naomi Adelola, Venkatramanan Varadharajan, Tolulope Uzoka, Rukayat Olajumoke Onilegbale, Chioma Ekwedigwe, Habeebah Fakayode, Zainab Ashimuyu-Abdulsalam, Akorede Daniel Aladeitan, Elizabeth Oladipo, Babatunde Salako, Adeola Olukosi   +13 more
doaj   +1 more source

Mapping and characterization of visna/maedi virus cytotoxic T-lymphocyte epitopes

Journal of General Virology, 2008
CD8+cytotoxic T-lymphocyte (CTL) responses have been shown to be important in the control of human and simian immunodeficiency virus infections. Infection of sheep with visna/maedi virus (VISNA), a related lentivirus, induces specific CD8+CTLin vivo, but the specific viral proteins recognized are not known.
Changxin, Wu, Cyril, Barbezange, Ian, McConnell, Barbara A, Blacklaws   +3 more
openaire   +2 more sources

Immunoinformatics design of multivalent epitope vaccine against monkeypox virus and its variants using membrane-bound, enveloped, and extracellular proteins as targets

Frontiers in Immunology, 2023
IntroductionThe current monkeypox (MPX) outbreak, caused by the monkeypox virus (MPXV), has turned into a global concern, with over 59,000 infection cases and 23 deaths worldwide.ObjectivesHerein, we aimed to exploit robust immunoinformatics approach ...
Muhammad Waqas, Muhammad Waqas, Shahkaar Aziz, Pietro Liò, Yumna Khan, Amjad Ali, Aqib Iqbal, Aqib Iqbal, Faizullah Khan, Faizullah Khan, Fahad Nasser Almajhdi   +10 more
doaj   +1 more source