Results 21 to 30 of about 50,861 (164)

Genome-wide Characterization of a Viral Cytotoxic T Lymphocyte Epitope Repertoire [PDF]

Journal of Biological Chemistry, 2003
A genome-wide search using major histocompatibility complex (MHC) class I binding and proteosome cleavage site algorithms identified 101 influenza A PR8 virus-derived peptides as potential epitopes for CD8+ T cell recognition in the H-2b mouse. Cytokine-based flow cytometry, ELISPOT, and cytotoxic T lymphocyte assays reveal that 16 are recognized by ...
Zhong, Weimin, Reche Gallardo, Pedro Antonio, Lai, Char-Chang, Reinhold, Bruce, Reinherz, Ellis L   +4 more
openaire   +3 more sources

Cytotoxic T Lymphocyte Epitopes of HIV-1 Nef [PDF]

The Journal of Experimental Medicine, 2000
Although a pivotal role of proteasomes in the proteolytic generation of epitopes for major histocompatibility complex (MHC) class I presentation is undisputed, their precise function is currently the subject of an active debate: do proteasomes generate many epitopes in definitive form, or do they merely generate the COOH termini, whereas the definitive
M, Lucchiari-Hartz, P M, van Endert, G, Lauvau, R, Maier, A, Meyerhans, D, Mann, K, Eichmann, G, Niedermann   +7 more
openaire   +2 more sources

Identification of cytotoxic T lymphocyte epitopes of human herpesvirus 8

Immunology, 2002
SummaryThe human herpesvirus 8 (HHV‐8) is a human γ2‐herpesvirus that is implicated in the development of Kaposi's sarcoma (KS), primary effusion lymphoma and Castelman's disease. Since the responses of cytotoxic T lymphocytes (CTL) play a key role in the control of herpesvirus infection, it is important to identify and to characterize the CTL target ...
MICHELETTI, Fabiola, MONINI P., FORTINI, Cinzia, RIMESSI, Paola, BAZZARO M., ANDREONI M., GIULIANI M., TRANIELLO, Maria Serena, ENSOLI B., GAVIOLI, Riccardo   +9 more
openaire   +3 more sources

Identification of CD8 T-Lymphocyte Epitopes in OmpB ofRickettsia conorii [PDF]

Infection and Immunity, 2003
ABSTRACTThe 1.2-kb DNA fragment of theRickettsia conoriiouter membrane protein B gene (OmpB451-846) was subcloned using site-specific PCR primers and expressed as six smaller fragments: OmpB458-652, OmpB595-744, OmpB595-654, OmpB645-692, OmpB689-744, and OmpB739-848.
Zhen, Li, C Marcela, Díaz-Montero, Gustavo, Valbuena, Xue-Jie, Yu, Juan P, Olano, Hui-Min, Feng, David H, Walker   +6 more
openaire   +2 more sources

Effect of epitope flanking residues on the presentation of N-terminal cytotoxic T lymphocyte epitopes

European Journal of Immunology, 1999
We here demonstrate that placing two distinct influenza virus nucleoprotein epitopes at the N terminus of a cytosolic protein selectively blocks their presentation to specific cytotoxic T lymphocytes. The block is a cytosolic phenomenon, which can be overcome by distancing the epitope from the protein N terminus by two or more amino acids.
Gileadi, U, Gallimore, A, Van der Bruggen, P, Cerundolo, V   +3 more
openaire   +3 more sources

Large-scale validation of methods for cytotoxic T-lymphocyte epitope prediction [PDF]

BMC Bioinformatics, 2007
Reliable predictions of Cytotoxic T lymphocyte (CTL) epitopes are essential for rational vaccine design. Most importantly, they can minimize the experimental effort needed to identify epitopes. NetCTL is a web-based tool designed for predicting human CTL epitopes in any given protein.
Mette V. Larsen, Claus Lundegaard, Kasper Lamberth, Søren Buus, Ole Lund, Morten Nielsen 0001   +5 more
openaire   +4 more sources

Evolution of cytotoxic T-lymphocyte epitopes in hepatitis B virus

Infection, Genetics and Evolution, 2007
In hepatitis B virus (HBV), while mutations that escape from cytotoxic T-lymphocyte (CTL) recognition have been described it has been difficult to determine how natural selection by host CTL has influenced long-term evolution of HBV. We used statistical analysis of published HBV genomic sequences to examine the role of natural selection in evolution of
Kristi M, Westover, Austin L, Hughes
openaire   +2 more sources

Exploring the structural basis to develop efficient multi-epitope vaccines displaying interaction with HLA and TAP and TLR3 molecules to prevent NIPAH infection, a global threat to human health.

PLoS ONE, 2023
Nipah virus (NiV) is an emerging zoonotic virus that caused several serious outbreaks in the south asian region with high mortality rates ranging from 40 to 90% since 2001. NiV infection causes lethal encephalitis and respiratory disease with the symptom
Sukrit Srivastava, Sonia Verma, Mohit Kamthania, Ajay Kumar Saxena, Kailash C Pandey, Veena Pande, Michael Kolbe   +6 more
doaj   +3 more sources

B- and T-lymphocyte responses to an immunodominant epitope of human immunodeficiency virus [PDF]

Journal of Virology, 1988
Using synthetic peptides, we characterized the B-lymphocyte (antibody) and T-lymphocyte (proliferation) responses to an immunodominant epitope of human immunodeficiency virus type 1 (HIV-1) located near the amino-terminal end of the transmembrane glycoprotein (env amino acids 598 to 609).
R D, Schrier, J W, Gnann, A J, Langlois, K, Shriver, J A, Nelson, M B, Oldstone   +5 more
openaire   +2 more sources

Designing a multi-epitope vaccine to control porcine epidemic diarrhea virus infection using immunoinformatics approaches

Frontiers in Microbiology, 2023
Porcine epidemic diarrhea virus (PEDV), a continuously evolving pathogen, causes severe diarrhea in piglets with high mortality rates. However, current vaccines cannot provide complete protection against PEDV, so vaccine development is still necessary ...
Wei Hou, Heqiong Wu, Sibei Wang, Wenting Wang, Bin Wang, Bin Wang, Haidong Wang   +6 more
doaj   +1 more source