Results 11 to 20 of about 50,861 (164)

Epitope Prediction Assays Combined with Validation Assays Strongly Narrows down Putative Cytotoxic T Lymphocyte Epitopes [PDF]

Vaccines, 2015
Tumor vaccine design requires prediction and validation of immunogenic MHC class I epitopes expressed by target cells as well as MHC class II epitopes expressed by antigen-presenting cells essential for the induction of optimal immune responses.
Peng Peng Ip, Hans W. Nijman, Toos Daemen   +2 more
doaj   +3 more sources

Different dose-based multi HN & F epitope mRNA vaccine against Newcastle disease [PDF]

Open Veterinary Journal
Background: Newcastle disease virus (NDV) is considered a major player in the ongoing challenges in the poultry farming system due to its virulence, which affects productivity.
Asma Abdlhusen Shrshoh, Nafea Sabih Jasim   +1 more
doaj   +2 more sources

Bioinformatics-driven design and protective efficacy assessment of a multi-epitope vaccine for Toxoplasma gondii [PDF]

Frontiers in Immunology
IntroductionToxoplasma gondii can cause toxoplasmosis. It is an important type of pathogen within the broad category of emerging and re-emerging zoonoses.
Wenyong Feng, Wenyong Feng, Lu Sun, Chenglong Yang, Chenglong Yang, Jie Cao, Yongzhi Zhou, Jinlin Zhou, Longzheng Yu, Houshuang Zhang   +9 more
doaj   +2 more sources

Phylogenetic and Immune Epitope Analysis of Hepatitis B Surface Antigen in Chronic Carriers from Tabriz, Northwest of Iran [PDF]

ImmunoAnalysis, 2022
Background: The purpose of this investigation was to specify the genotypes and subtypes of hepatitis B virus (HBV) by phylogenetic analysis and to investigate the mutations in the S gene region in chronic patients with hepatitis B surface antigen (HBsAg)-
Fatemeh Ebrahimi, Mahin Ahangar Oskoee, Hossein Bannazadeh Baghi, Javid Sadeghi, Mohammad Ahangarzadeh Rezaei, Omid Gholizadeh, Nader Mohammadzadeh, Ahmad Dashti, Vahdat Poortahmasebi   +8 more
doaj   +1 more source

Designing a multi-epitope vaccine against Peptostreptococcus anaerobius based on an immunoinformatics approach

Synthetic and Systems Biotechnology, 2023
Peptostreptococcus anaerobius is an anaerobic bacterium, which has been found selectively en-riched in the fecal and mucosal microbiota of colorectal cancer (CRC) patients. Emerging evidence suggest P.
Yudan Mao, Xianzun Xiao, Jie Zhang, Xiangyu Mou, Wenjing Zhao   +4 more
doaj   +1 more source

Design of a Recombinant Multivalent Epitope Vaccine Based on SARS-CoV-2 and Its Variants in Immunoinformatics Approaches

Frontiers in Immunology, 2022
The development of an effective multivalent vaccine against SARS-CoV-2 variants is an important means to improve the global public health situation caused by COVID-19. In this study, we identified the antigen epitopes of the main global epidemic SARS-CoV-
Mingkai Yu, Mingkai Yu, Yuejie Zhu, Yujiao Li, Zhiqiang Chen, Zhiqiang Chen, Zhiwei Li, Jing Wang, Zheng Li, Fengbo Zhang, Fengbo Zhang, Jianbing Ding, Jianbing Ding   +12 more
doaj   +1 more source

Design of a multi-epitope vaccine candidate against Brucella melitensis

Scientific Reports, 2022
Brucella is a typical facultative intracellular bacterium that can cause zoonotic infections. For Brucella, it is difficult to eliminate with current medical treatment.
Min Li, Yuejie Zhu, Ce Niu, Xinru Xie, Gulishati Haimiti, Wenhong Guo, Mingkai Yu, Zhiqiang Chen, Jianbing Ding, Fengbo Zhang   +9 more
doaj   +1 more source

Sporozoite glycoprotein antigen (SGA) of Cryptosporidium parvum is a promising vaccine target for prevention of cryptosporidiosis In silico analysis of C. parvum SGA protein

Informatics in Medicine Unlocked, 2023
Cryptosporidiosis is a zoonotic parasitic infection causing diarrhea in humans and farm animals. The present study was done to computationally analyze the Cryptosporidium parvum sporozoite glycoprotein antigen (SGA) regarding immunogenic epitopes, as a ...
Bahareh Kordi, Amir Fotovati, Hamidreza Majidiani, Hadi Fazel, Esfandiar Azizi, Morteza Shams, Amir Abaszadeh   +6 more
doaj   +1 more source

Common Antiviral Cytotoxic T-Lymphocyte Epitope for Diverse Arenaviruses [PDF]

Journal of Virology, 2001
ABSTRACT Members of the Arenaviridae family have been isolated from mammalian hosts in disparate geographic locations, leading to their grouping as Old World types (i.e., lymphocytic choriomeningitis virus [LCMV], Lassa fever virus [LFV], Mopeia virus, and Mobala virus) and New World types (i.e., Junin ...
M B, Oldstone, H, Lewicki, D, Homann, C, Nguyen, S, Julien, J E, Gairin   +5 more
openaire   +2 more sources

Identification of CTL Epitopes on Efflux Pumps of the ATP-Binding Cassette and the Major Facilitator Superfamily of Mycobacterium tuberculosis

Journal of Immunology Research, 2021
Tuberculosis is the world’s most deadly infectious disease, with 10 million people falling ill and 1.5 million people dying from the disease every year. With the increasing number of drug-resistant Mycobacterium tuberculosis (MTB) strains and prevalence ...
Yan Lin, Yu Dong, Yanfeng Gao, Ranran Shi, Yubing Li, Xiuman Zhou, Wenwen Liu, Guodong Li, Yuanming Qi, Yahong Wu   +9 more
doaj   +1 more source