Results 31 to 40 of about 50,861 (164)

Recognition of distinct epitopes on the HLA-A2 antigen by cytotoxic T lymphocytes

Human Immunology, 1986
Alloimmune CTLs specifically recognizing the HLA-A2.3 subtype could be made besides the previously described HLA-A2.1 and A2.2 subtype-specific CTLs. Examination of the fine specificity of 15 different CTLs directed against distinct HLA-A2 subtypes demonstrated further complexity of antigenic epitopes present on the A2 molecule.
Goulmy, E.A.J.M., Poel, J.J. van der, Pool, J., Giphart, M.J., Rood, J.J. van   +4 more
openaire   +3 more sources

In silico design of a promiscuous chimeric multi-epitope vaccine against Mycobacterium tuberculosis

Computational and Structural Biotechnology Journal, 2023
Tuberculosis (TB) is a global health threat, killing approximately 1.5 million people each year. The eradication of Mycobacterium tuberculosis, the main causative agent of TB, is increasingly challenging due to the emergence of extensive drug-resistant ...
Binda T. Andongma, Yazheng Huang, Fang Chen, Qing Tang, Min Yang, Shan-Ho Chou, Xinfeng Li, Jin He   +7 more
doaj   +1 more source

An Approach for a Synthetic CTL Vaccine Design against Zika Flavivirus Using Class I and Class II Epitopes Identified by Computer Modeling

Frontiers in Immunology, 2017
The threat posed by severe congenital abnormalities related to Zika virus (ZKV) infection during pregnancy has turned development of a ZKV vaccine into an emergency.
Edecio Cunha-Neto, Edecio Cunha-Neto, Edecio Cunha-Neto, Daniela S. Rosa, Daniela S. Rosa, Paul E. Harris, Tim Olson, Alex Morrow, Serban Ciotlos, Charles V. Herst, Reid Martin Rubsamen, Reid Martin Rubsamen   +11 more
doaj   +1 more source

Designing a Multi-Epitope Vaccine against Toxoplasma gondii: An Immunoinformatics Approach

Vaccines, 2022
Infection with the intracellular apicomplexan parasite Toxoplasma gondii causes serious clinical outcomes in both human and veterinary settings worldwide. Although approximately one-third of the world’s population is infected with T. gondii, an effective
Mutiat Hammed-Akanmu, Maria Mim, Abdinasir Yusuf Osman, Abdulrahman M. Sheikh, Esmaeil Behmard, Ali A. Rabaan, Rapeah Suppain, Khalid Hajissa   +7 more
doaj   +1 more source

Epitopes recognized by human T lymphocytes in the ROP2 protein antigen of Toxoplasma gondii [PDF]

Infection and Immunity, 1996
The ROP2 protein of Toxoplasma gondii possesses immunological and biological properties which have led to its proposal as a vaccine candidate. To identify epitopes recognized by human T cells in the ROP2 antigen, we submitted the sequence of this protein to three reported T-cell epitope prediction algorithms.
Saavedra, Rafael, Becerril, Marco Antonio, Dubeaux, Christine, Lippens, Renée, De Vos, Marie-Joëlle, Herion, Pascal, Bollen, Alex   +6 more
openaire   +3 more sources

Computational multi-epitope based design of a multivalent subunit vaccine against co-infecting African swine fever virus and porcine circovirus type 2

Veterinary Integrative Sciences
African swine fever virus (ASFV) and porcine circovirus type 2 (PCV2) are two prevalent and economically significant viruses causing high rates of pig mortality and large-scale losses to global pork production.
Lauren Emily Fajardo, Edward C. Banico, Ella Mae Joy S. Sira, Nyzar Mabeth O. Odchimar, Fredmoore L. Orosco   +4 more
doaj   +1 more source

Antigen-specific T cell responses in autoimmune diabetes

Frontiers in Immunology
Autoimmune diabetes is a disease characterized by the selective destruction of insulin-secreting β-cells of the endocrine pancreas by islet-reactive T cells.
Alexander J. Dwyer, Zachary R. Shaheen, Brian T. Fife   +2 more
doaj   +1 more source

Chimeric Vaccine Design against Dengue Virus Using Immunoinformatics and Docking Approaches [PDF]

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul
Background and Objective: Over the past five years, transmission of the dengue virus to humans by infected Aedes mosquitoes has increased significantly.
A Asadzadeh, K Dastan, N Ghorbani
doaj  

Integrating immunoinformatics and computational epitope prediction for a vaccine candidate against respiratory syncytial virus

Infectious Disease Modelling
Respiratory syncytial virus (RSV) poses a significant global health threat, especially affecting infants and the elderly. Addressing this, the present study proposes an innovative approach to vaccine design, utilizing immunoinformatics and computational ...
Truc Ly Nguyen, Heebal Kim
doaj   +1 more source

Prediction and identification of mouse cytotoxic T lymphocyte epitopes in Ebola virus glycoproteins [PDF]

Virology Journal, 2012
Abstract Background Ebola viruses (EBOVs) cause severe hemorrhagic fever with a high mortality rate. At present, there are no licensed vaccines or efficient therapies to combat EBOV infection. Previous studies have shown that both humoral and cellular immune responses are crucial for controlling Ebola infection.
Wu Shipo, Yu Ting, Song Xiaohong, Yi Shaoqiong, Hou Lihua, Chen Wei   +5 more
openaire   +3 more sources