Results 41 to 50 of about 50,861 (164)

A robust comprehensive immunoinformatics approach for designing a potential multi-epitope based vaccine against a reiterated monkeypox virus

Biochemistry and Biophysics Reports
Mpox, a viral disease, caused by the monkeypox virus (MPXV) has been a public health emergency of international concern since 2024. The absence of any mpox-specific treatment or vaccine, along with the emergence of new variants like Clade Ib, underscores
Khalid Hasan Raj, Emam Hossain, Hasnat Zahin, Abdullah Al Noman, Abdullah Al Saba, Mohammad Sayem, Tahirah Yasmin, A.H.M. Nurun Nabi   +7 more
doaj   +1 more source

Activation of epitope-specific memory cytotoxic T lymphocyte responses by synthetic peptides [PDF]

Clinical and Experimental Immunology, 1996
Abstract Cytotoxic T lymphocytes (CTL) recognize antigens as short peptides selected for presentation by their ability to bind to MHC class I molecules. Polyclonal Epstein–Barr virus (EBV)-specific memory CTL responses, reactivated from blood lymphocytes of HLA-A11-positive individuals by stimulation with the autologous EBV-transformed ...
REALI E., GUERRINI, Remo, GIORI B., BORGHI M., MARASTONI, Mauro, TOMATIS, Roberto, TRANIELLO S., MASUCCI M. G., GAVIOLI, Riccardo   +8 more
openaire   +3 more sources

A comprehensive strategy for the development of a multi-epitope vaccine targeting Treponema pallidum, utilizing heat shock proteins, encompassing the entire process from vaccine design to in vitro evaluation of immunogenicity

Frontiers in Microbiology
BackgroundTreponema pallidum, the causative spirochete of syphilis, is primarily transmitted through sexual contact and has emerged as a significant global health concern.
Jing Jiang, Jing Jiang, Linglan Xu, Linglan Xu, Xuefeng Wang, Ming Wang, Youde Cao, Ranhui Li, Kang Zheng, Xian Wu   +9 more
doaj   +1 more source

Spread of T Lymphocyte Immune Responses to Myelin Epitopes With Duration of Multiple Sclerosis [PDF]

Journal of Neuropathology & Experimental Neurology, 2005
Although the primary cause of multiple sclerosis (MS) is unclear, evidence supports a role for autoimmune attack of myelin by T lymphocytes. However, it has been difficult to relate patterns of autoimmunity to pathogenesis. In mouse models, the case has been made for relapsing and remitting disease driven by epitope spread: an initial lesion leads to ...
Selina, Davies, Tim, Nicholson, Matilde, Laura, Gavin, Giovannoni, Daniel M, Altmann   +4 more
openaire   +2 more sources

Design of A Multi-epitope Vaccine Candidate against Q Fever based on the Outer Mem-brane Proteins OMP1 and LolB: An Immunoinformatic Study [PDF]

Iranian South Medical Journal
Background: Q fever—caused by Coxiella burnetii—is a zoonotic disease reported worldwide. It can cause severe complications in the host, manifesting with conditions such as liver, heart, and vascular failure, pneumonia, and long-term chronic fatigue ...
Hamid Vaez, Ladan Shahrakimojahed
doaj  

Molecular assessment of the HIV pol gene and use of computational vaccine design targeting Pakistani isolates

Scientific Reports
Human immunodeficiency virus (HIV) is considered a major threat to human health. The global prevalence of individuals infected with HIV-1 continues to rise.
Akmal Zubair, Faisal Ahmad, Syeda Maryam Hussain, Zahid Manzoor, Ahmed Al-Emam, Safa Wdidi   +5 more
doaj   +1 more source

In silico screening and identification of CTL and HTL epitopes in the secreted virulence factors of Mycobacterium tuberculosis

BioTechnologia
Background Mycobacterium tuberculosis (MTb) is a highly infectious pathogen and a global health threat due to its resilient cell wall and immune evasion strategies.
Edward Kevin Bragais, Francisco M. Heralde III, Kim Claudette J. Fernandez, Salvador Eugenio C. Caoili, Leana Rich Herrera-Ong   +4 more
doaj   +1 more source

Molecular anatomy and number of antigen specific CD8 T cells required to cause type 1 diabetes.

PLoS Pathogens, 2012
We quantified CD8 T cells needed to cause type 1 diabetes and studied the anatomy of the CD8 T cell/beta (β) cell interaction at the immunologic synapse.
Michael B A Oldstone, Kurt H Edelmann, Dorian B McGavern, Justin T Cruite, Megan J Welch   +4 more
doaj   +1 more source

Immunoinformatic design of chimeric multiepitope vaccine for the prevention of human metapneumovirus (hMPV)

BMC Infectious Diseases
Background Human metapneumovirus (hMPV) is a significant etiological agent of acute respiratory infections in children and immunocompromised individuals.
Maryam Ehsasatvatan, Bahram Baghban Kohnehrouz, Mohammad Salavatizadeh   +2 more
doaj   +1 more source

Novel dual-pathogen multi-epitope mRNA vaccine development for Brucella melitensis and Mycobacterium tuberculosis in silico approach.

PLoS ONE
Brucellosis and Tuberculosis, both of which are contagious diseases, have presented significant challenges to global public health security in recent years. Delayed treatment can exacerbate the conditions, jeopardizing patient lives.
Yuejie Zhu, Juan Shi, Quan Wang, Yun Zhu, Min Li, Tingting Tian, Huidong Shi, Kaiyu Shang, Zhengwei Yin, Fengbo Zhang   +9 more
doaj   +1 more source