Results 1 to 10 of about 3,636,379 (304)

Immunoinformatics‐Based Multi‐Epitope Vaccine Targeting Helicobacter Pylori [PDF]

Cancer Reports
Background The rising global incidence of Helicobacter pylori‐related diseases, particularly gastric cancer, underscores the urgent need for effective preventive vaccines, motivating the exploration of innovative immunoinformatic strategies to address ...
Aytak Vahdat Khajeh Pasha, Mohammad Esfandiyari, Alireza Parnian, Mohammad Mahboubi‐Rabbani, Maryam Bayanati   +4 more
doaj   +4 more sources

Design of a Helicobacter pylori multi-epitope vaccine based on immunoinformatics

Frontiers in Immunology
Helicobacter pylori (H. pylori) is an infectious bacterium that colonizes the stomach of approximately half of the global population. It has been classified as a Group I carcinogen by the World Health Organization due to its strong association with an ...
Man Cui, Man Cui, Xiaohui Ji, Xiaohui Ji, Fengtao Guan, Fengtao Guan, Guimin Su, Guimin Su, Lin Du, Lin Du   +9 more
doaj   +5 more sources

The Construction of A Multi-epitope Vaccine Against Klebsiella pneumoniae Using in silico Approach

MCBS (Molecular and Cellular Biomedical Sciences), 2023
Background: Klebsiella pneumoniae is one of the bacteria that causes pneumonia infection. Even though the number of pneumonia cases is relatively high and has become a global problem, there is still no vaccine available to prevent this disease.
Dhammiko Wonggo, Mariana Wahjudi
doaj   +2 more sources

Immunoinformatics-driven multi-epitope vaccine design targeting PSMA, STEAP1, and B7H3 for prostate cancer [PDF]

Frontiers in Medicine
IntroductionProstate cancer remains a major global health challenge, necessitating precision immunotherapeutic strategies tailored to tumor-associated antigens.
Stefanus Vicky Bernhard Elisa Runtunuwu, Trina Ekawati Tallei, Trina Ekawati Tallei, Trina Ekawati Tallei, Hyo Jeong Kim, Moon Nyeo Park, Moon Nyeo Park, Ismail Celik, Burak Kirilmaz, Grace Lendawati Amelia Turalaki, Fatimawali Fatimawali, Lydia Estelina Naomi Tendean, Martha Marie Kaseke, Dionisius Rafael Makawaehe, Elne Vieke Rambi, Bonglee Kim, Bonglee Kim   +16 more
doaj   +2 more sources

The long multi-epitope peptide vaccine combined with adjuvants improved the therapeutic effects in a glioblastoma mouse model

Frontiers in Immunology, 2022
Emerging data have suggested that single short peptides have limited success as a cancer vaccine; however, extending the short peptides into longer multi-epitope peptides overcame the immune tolerance and induced an immune response.
Thi-Anh-Thuy Tran, Thi-Anh-Thuy Tran, Young-Hee Kim, Ga-Eun Kim, Shin Jung, Shin Jung, In-Young Kim, In-Young Kim, Kyung-Sub Moon, Kyung-Sub Moon, Young-Jin Kim, Young-Jin Kim, Tae-Kyu Lee, Tae-Kyu Lee, Hyosuk Yun, Je-Jung Lee, Je-Jung Lee, Hyun-Ju Lee, Chul Won Lee, Tae-Young Jung, Tae-Young Jung, Tae-Young Jung   +21 more
doaj   +1 more source

A Computational Reverse Vaccinology Approach for the Design and Development of Multi-Epitopic Vaccine Against Avian Pathogen Mycoplasma gallisepticum

Frontiers in Veterinary Science, 2021
Avian mycoplasma is a bacterial disease causing chronic respiratory disease (CRD) in poultry industries with high economic losses. The eradication of this disease still remains as a challenge.
Susithra Priyadarshni Mugunthan, Harish Mani Chandra   +1 more
doaj   +1 more source

Exploring YidR Gene from Klebsiella pneumoniae To Design a Multi-epitope Vaccine Using Immunoinformatics Approach

Journal of Experimental Life Science, 2022
Klebsiella pneumoniae is the main leading cause of hospital-acquired infection, leading to severe infections such as pneumonia and urinary tract infection.
Maulana Wildan Seputra, Hani Susiati, Tri Yudani Mardining Raras   +2 more
doaj   +1 more source

Exploring rotavirus proteome to identify potential B- and T-cell epitope using computational immunoinformatics

Heliyon, 2020
Rotavirus is the most common cause of acute gastroenteritis in infants and children worldwide. The functional correlation of B- and T-cells to long-lasting immunity against rotavirus infection in the literature is limited.
Yengkhom Damayanti Devi, Arpita Devi, Hemanga Gogoi, Bondita Dehingia, Robin Doley, Alak Kumar Buragohain, Ch. Shyamsunder Singh, Partha Pratim Borah, C.Durga Rao, Pratima Ray, George M. Varghese, Sachin Kumar, Nima D. Namsa   +12 more
doaj   +1 more source

In silico design of recombinant multi-epitope vaccine against influenza A virus

BMC Bioinformatics, 2022
Background Influenza A virus is one of the leading causes of annual mortality. The emerging of novel escape variants of the influenza A virus is still a considerable challenge in the annual process of vaccine production.
Avisa Maleki, Giulia Russo, Giuseppe Alessandro Parasiliti Palumbo, Francesco Pappalardo   +3 more
doaj   +1 more source

Design of a novel multiepitope vaccine against Chlamydia pneumoniae using the extracellular protein as a target

Scientific Reports, 2023
Chlamydia pneumoniae (C. pneumoniae) infection in humans is universal and causes various respiratory infectious diseases, making a safe and effective preventive vaccine essential. In this study, a multi-epitope vaccine with CTLA-4 extracellular structure
Xiaomei Guo, Xiaohong Pan, Qiangming Sun, Yunzhang Hu, Jiandong Shi   +4 more
doaj   +1 more source