Results 31 to 40 of about 3,636,379 (304)

Immunoinformatics approach for design novel multi-epitope prophylactic and therapeutic vaccine based on capsid proteins L1 and L2 and oncoproteins E6 and E7 of human papillomavirus 16 and human papillomavirus 18 against cervical cancer [PDF]

Osong Public Health and Research Perspectives
Objectives This study aimed to identify the optimal protein construction for designing a multi-epitope vaccine with both prophylactic and therapeutic effects against cervical cancer, utilizing an immunoinformatics approach.
Nicholas Ryan, Sari Eka Pratiwi, Mardhia Mardhia, Ysrafil Ysrafil, Delima Fajar Liana, Mahyarudin Mahyarudin   +5 more
doaj   +1 more source

Immunoinformatics Approach to Design a Multi-Epitope Vaccine against Cutaneous Leishmaniasis

, 2023
Cutaneous Leishmaniasis (CL), a neglected vector-borne disease caused by protozoan parasite Leishmania major (L. major), is a major public health concern, and the development of new strategies to reduce the disease incidence has become a top priority ...
Esra Atalay Şahar, Ayse Caner, Yusuf Ozbel, Shumaila Naz, Sumra Wajid Abbasi, Seray Toz, Aiman Aroosh   +6 more
core   +1 more source

A Comparative Analysis of Computational Strategies in Multi-Epitope Vaccine Design Against Human Papillomavirus and Cervical Cancer [PDF]

Cell Journal
Given the critical role of human papillomavirus (HPV) in the cause of cervical cancer and other malignancies, there is aneed for innovative approaches to preventing this infection.
Ali Najafi, Mohammad Ataee, Mahdieh Farzanehpour, Hadi Esmaeili Guvarchin Ghaleh   +3 more
doaj   +1 more source

In silico design of a multi-epitope vaccine against HPV16/18

BMC Bioinformatics, 2022
Abstract Background Cervical cancer is the fourth most common cancer affecting women and is caused by human Papillomavirus (HPV) infections that are sexually transmitted. There are currently commercially available prophylactic vaccines that have been shown to protect vaccinated individuals against HPV infections, however,
Samira Sanami, Mahmoud Rafieian-Kopaei, Korosh Ashrafi Dehkordi, Hamidreza Pazoki-Toroudi, Fatemeh Azadegan-Dehkordi, Gholam-Reza Mobini, Morteza Alizadeh, Muhammad Sadeqi Nezhad, Maryam Ghasemi-Dehnoo, Nader Bagheri   +9 more
openaire   +4 more sources

Preferential amplification of CD8 effector-T cells after transcutaneous application of an inactivated influenza vaccine: a randomized phase I trial [PDF]

, 2010
Background: Current conventional vaccination approaches do not induce potent CD8 T-cell responses for fighting mostly variable viral diseases such as influenza, avian influenza viruses or HIV.
van der Werf, Sylvie, Christine Katlama, Annika Vogt, Dominique Costagliola, Katlama, Christine, Sabrina Hadam, Behazine Combadière, Sterry, Wolfram, Vogt, Annika, Costagliola, Dominique, Autran, Brigitte, Blume-Peytav, Ulrike, Brice Mahé, Wolfram Sterry, Bonduelle, Olivia, Shlomo Staszewski, Ulrike Blume-Peytavi, Brigitte Autran, Olivia Bonduelle, Blume-Peytavi, Ulrike, Combadière, Behazine, Mahé, Brice, Hadam, Sabrina, Schaefer, Hans, Staszewski, Shlomo, Hans Schaefer, Sylvie van der Werf   +26 more
core   +2 more sources

Additional file 1 of Design of a multi-epitope-based peptide vaccine against the S and N proteins of SARS-COV-2 using immunoinformatics approach

, 2022
Additional file 1. Design of a multi-epitope-based peptide vaccine against the S and N proteins of SARS -COV-2 using Immunoinformatics Approach. ( http://galaxy.seoklab.org/cgi-bin/report_REFINE.cgi?key=27ac3cd2f0bd1f0372ce673a67eac9e1 , https://npsa ...
Farnaz Kheirandish (805358), Seyedeh Zeinab Hosseini (12044459), Arian Karimi Rouzbahani (12044456)   +2 more
core   +1 more source

A Rational Design of a Multi-Epitope Vaccine Against SARS-CoV-2 Which Accounts for the Glycan Shield of the Spike Glycoprotein [PDF]

, 2020
The ongoing global health crisis caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the virus which leads to Coronavirus Disease 2019 (COVID-19) has impacted not only the health of people everywhere, but the economy in nations across
William R., Martin, Feixiong, Cheng
core   +1 more source

Immunoinformatics Design of Multi-Epitope Peptide-Based Vaccine Against Schistosoma mansoni Using Transmembrane Proteins as a Target

Frontiers in Immunology, 2021
Schistosomiasis remains a serious health issue nowadays for an estimated one billion people in 79 countries around the world. Great efforts have been made to identify good vaccine candidates during the last decades, but only three molecules reached ...
Rodrigo C. O. Sanches, Sandeep Tiwari, Laís C. G. Ferreira, Flávio M. Oliveira, Marcelo D. Lopes, Maria J. F. Passos, Eduardo H. B. Maia, Eduardo H. B. Maia, Alex G. Taranto, Rodrigo Kato, Vasco A. C. Azevedo, Debora O. Lopes   +11 more
doaj   +1 more source

Development of a Novel Multi-Epitope Vaccine Candidate against Streptococcus Iniae Infection in Fish: An Immunoinformatics Study [PDF]

Archives of Razi Institute, 2022
Streptococcus iniae infection is recognized as a disease with substantial economic losses, infecting a wide range of fish species. The limitations of current vaccines and strategies have led to the identification of new methods to control this disease ...
Ali Forouharmehr, A Banan, S. M Mousavi, A Jaydari   +3 more
doaj   +1 more source

A multi-method and structure-based in silico vaccine designing against Echinococcus granulosus through investigating enolase protein [PDF]

BioImpacts, 2019
Introduction: Hydatid disease is a ubiquitous parasitic zoonotic disease, which causes different medical, economic and serious public health problems in some parts of the world.
Mohammad Mostafa Pourseif, Mitra Yousefpour, Mohammad Aminianfar, Gholamali Moghaddam, Ahmad Nematollahi   +4 more
doaj   +1 more source