Results 11 to 20 of about 3,636,379 (304)

Bioinformatics analysis for the purpose of designing a novel multi-epitope DNA vaccine against Leishmania major

Scientific Reports, 2022
Leishmaniasis is one of the main infectious diseases worldwide. In the midst of all the different forms of the disease, Cutaneous Leishmania (CL) has the highest incidence in the world.
Sama Rashidi, Seyed Nooreddin Faraji, Amirreza Javadi Mamaghani, Saeid Hatam, Bahram Kazemi, Peyman Bemani, Seyyed Javad Seyyed Tabaei, Gholamreza Hatam   +7 more
doaj   +2 more sources

VaccineDesigner: A Web-Based Tool for Streamlined Multi-Epitope Vaccine Design

Biology
Background: Multi-epitope vaccines have become the preferred strategy for protection against infectious diseases by integrating multiple MHC-restricted T-cell and B-cell epitopes that elicit both humoral and cellular immune responses against pathogens ...
Dimitrios Trygoniaris, Anna Korda, Anastasia Paraskeva, Esmeralda Dushku, Georgios Tzimagiorgis, Minas Yiangou, Charalampos Kotzamanidis, Andigoni Malousi   +7 more
doaj   +2 more sources

Application of In-Silico Reverse Vaccinology for Designing Multi-Epitope Vaccine Against Coronavirus [PDF]

, 2020
In absence of any specific medication or vaccine till now, experimentation has reached new heights. With lockdown imposed in almost every country and huge economic losses the search for a suitable vaccine has still been unsuccessful.
Dr. Shubhangi, Dange, Kumar, Sharp
core   +1 more source

Vaccinomics to Design a Multi-Epitopes Vaccine for Acinetobacter baumannii

International Journal of Environmental Research and Public Health, 2022
Antibiotic resistance (AR) is the result of microbes’ natural evolution to withstand the action of antibiotics used against them. AR is rising to a high level across the globe, and novel resistant strains are emerging and spreading very fast. Acinetobacter baumannii is a multidrug resistant Gram-negative bacteria, responsible for causing severe ...
Miraj ud-din, Aqel Albutti, Asad Ullah, Saba Ismail, Sajjad Ahmad, Anam Naz, Muhammad Khurram, Mahboob ul Haq, Zobia Afsheen, Youness El Bakri, Muhammad Salman, Bilal Shaker, Muhammad Tahir ul Qamar   +12 more
openaire   +2 more sources

Multi-epitope vaccine candidate design for dengue virus

Bioinformation, 2023
Dengue Fever (DF) is a vector-borne neglected viral disease with a high burden in the sub-tropics of Asia and Africa. Aedes aegypti is responsible for 90% of cases in the global burden of disease. The primary goal of the treatment is to eliminate the virus from the bloodstream of affected individuals.
Dharani, A, Ezhilarasi, DR, Priyadarsini, G, Abhinand, PA   +3 more
openaire   +2 more sources

Immunogenicity of a multi-epitope DNA vaccine against hantavirus [PDF]

Human Vaccines & Immunotherapeutics, 2012
Hemorrhagic fever with renal syndrome (HFRS) is a severe epidemic disease caused by hantaviruses including Hantaan virus (HTNV), Seoul virus (SEOV), Dobrava virus (DOBV) and Puumala virus. Three of the four HFRS hantaviruses, HTNV, SEOV, and PUUV are found in China. Currently, there is no effective strategy available to reduce infection risk.
Chen, Zhao, Ying, Sun, Yujie, Zhao, Si, Wang, Tongtong, Yu, Feng, Du, X Frank, Yang, Enjie, Luo   +7 more
openaire   +2 more sources

A Candidate multi-epitope vaccine against SARS-CoV-2 [PDF]

Scientific Reports, 2020
Abstract In the past two decades, 7 coronaviruses have infected the human population, with two major outbreaks caused by SARS-CoV and MERS-CoV in the year 2002 and 2012, respectively. Currently, the entire world is facing a pandemic of another coronavirus, SARS-CoV-2, with a high fatality rate.
Kar Tamalika, Narsaria Utkarsh, Basak Srijita, Deb Debashrito, Castiglione Filippo, Mueller David M, Srivastava Anurag P   +6 more
openaire   +6 more sources

Computational Design of a Multi-Epitope Vaccine Against Porphyromonas gingivalis [PDF]

Frontiers in Immunology, 2022
Porphyromonas gingivalisis a Gram-negative pathogenic bacterium associated with chronic periodontitis. The development of a chimeric peptide-based vaccine targeting this pathogen could be highly beneficial in preventing oral bone loss as well as other severe gum diseases.
Bilal Shaker, Sajjad Ahmad, Junhao Shen, Hyung Wook Kim, Dokyun Na   +4 more
openaire   +3 more sources

Multi-Epitope-Based Vaccines for Colon Cancer Treatment and Prevention [PDF]

Frontiers in Immunology, 2021
BackgroundOverexpression of nonmutated proteins involved in oncogenesis is a mechanism by which such proteins become immunogenic. We questioned whether overexpressed colorectal cancer associated proteins found at higher incidence and associated with poor prognosis could be effective vaccine antigens.
Lauren R. Corulli, Denise L. Cecil, Ekram Gad, Marlese Koehnlein, Andrew L. Coveler, Jennifer S. Childs, Ronald A. Lubet, Mary L. Disis   +7 more
openaire   +3 more sources

In-silico Design of Multi-epitope Vaccine against Nipah Virus using Immunoinformatics Approach

, 2021
Nipah virus is a pleomorphic virus that causes high mortality with unpredictable outbreaks. The virus also shows high zoonotic potential with long term neurological damage after recovery further adding to the disease burden.
Suraj Raju, Debasish Sahoo, Vikas Kumar Bhari   +2 more
core   +1 more source