Results 1 to 10 of about 3,358,336 (306)
'Multi-epitope-targeted' immune-specific therapy for a multiple sclerosis-like disease via engineered multi-epitope protein is superior to peptides. [PDF]
PLoS ONE, 2011 Antigen-induced peripheral tolerance is potentially one of the most efficient and specific therapeutic approaches for autoimmune diseases. Although highly effective in animal models, antigen-based strategies have not yet been translated into practicable ...
Nathali Kaushansky +5 more
doaj +5 more sources
Multi-Epitope-Based Vaccine Candidate for Monkeypox: An In Silico Approach
Vaccines, 2022 Currently, there are limited treatment options available for the monkeypox disease. We used a computational strategy to design a specific antigenic vaccine against pathogens.
Sayed Aliul Hasan Abdi +5 more
doaj +5 more sources
Immunoinformatics‐Based Multi‐Epitope Vaccine Targeting Helicobacter Pylori [PDF]
Cancer ReportsBackground The rising global incidence of Helicobacter pylori‐related diseases, particularly gastric cancer, underscores the urgent need for effective preventive vaccines, motivating the exploration of innovative immunoinformatic strategies to address ...
Aytak Vahdat Khajeh Pasha +4 more
doaj +2 more sources
Design of a Novel Multi-Epitope Vaccine Against Echinococcus granulosus in Immunoinformatics
Frontiers in Immunology, 2021 All the time, echinococcosis is a global zoonotic disease which seriously endangers public health all over the world. In order to speed up the development process of anti-Echinococcus granulosus vaccine, at the same time, it can also save economic cost ...
Mingkai Yu +9 more
doaj +3 more sources
Epitope‐Resolved Digital SERS Profiling of Structurally Dynamic Antigens via a Multi‐Epitope Bispecific Antibody Framework [PDF]
Advanced ScienceDigital surface‐enhanced Raman scattering (SERS) immunoassays digitize epitope binding events to achieve ultrasensitive protein detection. However, existing implementations predominantly rely on single‐epitope recognition, yielding 1D molecular view of ...
Jing Wang +4 more
doaj +2 more sources
Effect of multi-epitope derived from HIV-1 on REM sleep deprivation-induced spatial memory impairment with respect to the level of immune factors in mice [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Sleep deprivation (SD) has a negative impact on cognitive functions including learning and memory. Many studies have shown that rapid-eye-movement (REM) SD also disrupts memory performance.
Roya Lahimgarzadeh +3 more
doaj +1 more source
Frontiers in Immunology, 2022 Emerging data have suggested that single short peptides have limited success as a cancer vaccine; however, extending the short peptides into longer multi-epitope peptides overcame the immune tolerance and induced an immune response.
Thi-Anh-Thuy Tran +21 more
doaj +1 more source
Zoonoses, 2022 No licensed vaccine is available to prevent the severe tick-borne disease Crimean-Congo hemorrhagic fever (CCHF), caused by the CCHF virus (CCHFV). This study sought to show that a combination of computational methods and data from published literature ...
Megan C. Mears, Dennis A. Bente
doaj +1 more source
Frontiers in Veterinary Science, 2021 Avian mycoplasma is a bacterial disease causing chronic respiratory disease (CRD) in poultry industries with high economic losses. The eradication of this disease still remains as a challenge.
Susithra Priyadarshni Mugunthan +1 more
doaj +1 more source
Virology Journal, 2020 Background An effective vaccine that prevents disease caused by hantaviruses is a global public health priority, but up to now, no vaccine has been approved for worldwide use.
Ying Ma +8 more
doaj +1 more source