Results 41 to 50 of about 3,358,336 (306)

QadirVax-19: A multi epitope-based vaccine against COVID-19 [PDF]

, 2022
An outbreak of COVID-19, caused by a novel virus named SARS-CoV-2, has become a global challenge which needs to be addressed immediately. It has high rate of transmission and severity of the disease varying from person to person.
Misha Mukhtar, Professor (Associate) Muhammad Imran Qadir   +1 more
core   +1 more source

Multi-Epitope-Based Vaccines for Colon Cancer Treatment and Prevention [PDF]

Frontiers in Immunology, 2021
BackgroundOverexpression of nonmutated proteins involved in oncogenesis is a mechanism by which such proteins become immunogenic. We questioned whether overexpressed colorectal cancer associated proteins found at higher incidence and associated with poor prognosis could be effective vaccine antigens.
Lauren R. Corulli, Denise L. Cecil, Ekram Gad, Marlese Koehnlein, Andrew L. Coveler, Jennifer S. Childs, Ronald A. Lubet, Mary L. Disis   +7 more
openaire   +3 more sources

Immunoinformatics study of CD40 ligand-targeting vaccine constructs: a novel immunotherapeutic approach [PDF]

Osong Public Health and Research Perspectives
Objectives Incorporating CD40 ligand (CD40L) into vaccine strategies has shown considerable potential for enhancing immune responses. In this study, we designed and formulated a CD40L-based multi-epitope vaccine construct using immunoinformatics ...
Seyed Amir Sadeghi, Mahroo Mohamadi, Hadi Bamehr, Fatemeh Heidarnejad, Azam Bolhassani   +4 more
doaj   +1 more source

Design of multi-epitope vaccine constructs of SARS-CoV-2.

, 2021
Design of multi-epitope vaccine constructs of SARS-CoV-2.
Vashkar Biswa (11707490), Chen Chongtham (11707487), Anutee Dolley (11707484), Robin Doley (2308216), Chongtham Shyamsunder Singh (11707499), Suvendra Kumar Ray (11707496), Chandrima Doley (11707481), Manabendra Mandal (1802338), Pabitra Nath (3589217), Yengkhom Damayanti Devi (11707472), Arpita Devi (9286923), Siddhartha Shankar Satapathy (11707493), Partha Pratim Borah (11707502), Aditya Kumar (2629198), Nima D. Namsa (11707505), Latonglila Jamir (10843498), Sandeep Das (439300), Sushmita Konwar (11707478), Dikshita Dowerah (9147290), Ramesh Chandra Deka (567929), Himanshu Ballav Goswami (11707475)   +20 more
core   +1 more source

Immunoinformatics approach for design novel multi-epitope prophylactic and therapeutic vaccine based on capsid proteins L1 and L2 and oncoproteins E6 and E7 of human papillomavirus 16 and human papillomavirus 18 against cervical cancer [PDF]

Osong Public Health and Research Perspectives
Objectives This study aimed to identify the optimal protein construction for designing a multi-epitope vaccine with both prophylactic and therapeutic effects against cervical cancer, utilizing an immunoinformatics approach.
Nicholas Ryan, Sari Eka Pratiwi, Mardhia Mardhia, Ysrafil Ysrafil, Delima Fajar Liana, Mahyarudin Mahyarudin   +5 more
doaj   +1 more source

Developing a multi-epitope vaccine candidate to combat porcine epidemic diarrhea virus and porcine deltacoronavirus co-infection by employing an immunoinformatics approach

Frontiers in Microbiology, 2023
Coinfection of porcine epidemic diarrhea virus (PEDV) and porcine deltacoronavirus (PDCoV) is common in pig farms, but there is currently no effective vaccine to prevent this co-infection.
Wei Hou, Heqiong Wu, Wenting Wang, Ruolan Wang, Wang Han, Sibei Wang, Bin Wang, Bin Wang, Haidong Wang   +8 more
doaj   +1 more source

A Comparative Analysis of Computational Strategies in Multi-Epitope Vaccine Design Against Human Papillomavirus and Cervical Cancer [PDF]

Cell Journal
Given the critical role of human papillomavirus (HPV) in the cause of cervical cancer and other malignancies, there is aneed for innovative approaches to preventing this infection.
Ali Najafi, Mohammad Ataee, Mahdieh Farzanehpour, Hadi Esmaeili Guvarchin Ghaleh   +3 more
doaj   +1 more source

Candidate multi-epitope vaccines in aluminium adjuvant induce high levels of antibodies with predefined multi-epitope specificity against HIV-1 [PDF]

FEMS Immunology & Medical Microbiology, 2000
Some neutralizing epitopes on HIV-1 envelope proteins were identified to induce antibodies which could effectively inhibit the infection of different strains in vitro. But only very low levels of these antibodies were determined in the HIV-1 infected individuals.
J, Ding, Y, Lu, Y, Chen
openaire   +2 more sources

Characteristics of in silico predicted multi-epitope peptides.

, 2020
Characteristics of in silico predicted multi-epitope peptides.
Abdelhamid Kidar (567550), Sarra Hamrouni (8582325), Jean-Loup Lemesre (558857), Rachel Bras-Gonçalves (558847), Elodie Petitdidier (558849), Karim Aoun (508425), Yasmine Messaoudi (8582328), Julie Pagniez (558854), Amel Meddeb-Garnaoui (558859), Rym Chamakh-Ayari (558846)   +9 more
core   +1 more source

Design of immunogenic and effective multi-epitope DNA vaccines for melanoma [PDF]

Cancer Immunology, Immunotherapy, 2011
Plasmid DNA vaccination is an attractive way to elicit T cell responses against infectious agents and tumor cells. DNA constructs can be designed to contain multiple T cell epitopes to generate a diverse immune response to incorporate numerous antigens and to reduce limitations due to MHC restriction into a single entity.
Hyun-Il, Cho, Esteban, Celis
openaire   +2 more sources