Results 51 to 60 of about 3,358,336 (306)

Survival After Hematopoietic Stem Cell Transplantation in Diamond–Blackfan Anemia Syndrome: The Role of Iron Overload—A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We assessed the effect of iron overload (IO) on mortality and complications following hematopoietic stem cell transplantation (HSCT) in patients with Diamond–Blackfan anemia syndrome (DBAS) in a systematic review of individual participant data and cohort data from observational studies.
Geoffrey Z. L. Kuppens, Evangelia Kiakou, Lieke de Zwart, Maurizio Miano, Eduard J. van Beers, Marc Bierings, Marije Bartels   +6 more
wiley   +1 more source

Design a multi-epitope vaccine candidate against Acinetobacter baumannii using advanced computational methods

AMB Express
Acinetobacter baumannii is a significant cause of hospital-acquired infections and is often resistant to multiple antibiotics. In this study, we designed a multi-epitope vaccine candidate using the outer membrane protein K (OmpK) of A. baumannii.
Hana Heidarinia, Elahe Tajbakhsh, Yadollah Bahrami, Mosayeb Rostamian   +3 more
doaj   +1 more source

The progress of peptide vaccine clinical trials in gynecologic oncology

Human Vaccines & Immunotherapeutics, 2022
Peptide vaccine are a type of immunotherapy that are synthesized according to the amino acid sequence of known or predicted tumor antigen epitopes. They are safe and well tolerated and have shown exciting results in gynecologic oncology.
Mi Tang, Jiang-Hui Cai, Hao-Yang Diao, Wen-Mei Guo, Xiao Yang, ShaSha Xing   +5 more
doaj   +1 more source

A Situational Assessment of the Diagnostic Landscape and Organizational Readiness to Implement Next‐Generation Sequencing at Two Childhood Cancer Treatment Centers in Ghana

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Next‐generation sequencing (NGS) has emerged as a promising approach to improve diagnostic accuracy, but its feasibility in low‐ and middle‐income countries remains unknown. This study characterized the diagnostic landscape and assessed organizational readiness for NGS implementation at two childhood cancer treatment centers in Accra ...
Melissa Carvalho, Emmanuella Amoako, Nihad Salifu, Lily Gloria Tagoe, Yaw Bediako, Michelle Hermiston, Catherine Segbefia   +6 more
wiley   +1 more source

Evaluation of immunoprotective effects of PlpE multi-epitope protein incorporated within the aluminum hydroxide-adjuvanted inactivated vaccine against Pasteurella multocida infection in chickens

Poultry Science
Pasteurella multocida (Pm) is a major zoonotic pathogen that causes avian cholera in poultry, leading to significant economic losses. Although inactivated vaccines are commonly used, their immunogenicity is limited, highlighting the need for safer and ...
Xuelian Xiang, Yi Sun, Haili Zhang, Xinrui Wu, Jing Xia, Xinfeng Han, Yong Huang, Min Cui   +7 more
doaj   +1 more source

Synthetic B-Cell Epitopes Eliciting Cross-Neutralizing Antibodies: Strategies for Future Dengue Vaccine.

PLoS ONE, 2016
Dengue virus (DENV) is a major public health threat worldwide. A key element in protection from dengue fever is the neutralising antibody response. Anti-dengue IgG purified from DENV-2 infected human sera showed reactivity against several peptides when ...
Babu Ramanathan, Chit Laa Poh, Kristin Kirk, William John Hannan McBride, John Aaskov, Lara Grollo   +5 more
doaj   +1 more source

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

In silico design of a multi-epitope vaccine against HPV16/18

BMC Bioinformatics, 2022
Abstract Background Cervical cancer is the fourth most common cancer affecting women and is caused by human Papillomavirus (HPV) infections that are sexually transmitted. There are currently commercially available prophylactic vaccines that have been shown to protect vaccinated individuals against HPV infections, however,
Samira Sanami, Mahmoud Rafieian-Kopaei, Korosh Ashrafi Dehkordi, Hamidreza Pazoki-Toroudi, Fatemeh Azadegan-Dehkordi, Gholam-Reza Mobini, Morteza Alizadeh, Muhammad Sadeqi Nezhad, Maryam Ghasemi-Dehnoo, Nader Bagheri   +9 more
openaire   +4 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Design, construction and evaluation of multi-epitope antigens for diagnosis of Lyme disease [PDF]

, 2017
Introduction Introduction and objective. Lyme disease (LD) is the most common vector-borne disease in the temperate zone of the Northern Hemisphere. Diagnosis of LD is mainly based on clinical symptoms supported with serology (detection of anti- Borrelia
Eva Schreterova, Lucia Borszekova Pulzova, Bhide, Mangesh, Mangesh Bhide, Borszekova Pulzova, Lucia, Lenka Potocnakova, Schreterova, Eva, Potocnakova, Lenka   +7 more
core   +2 more sources