Results 71 to 80 of about 3,358,336 (306)

Protection against lethal cytomegalovirus infection by a recombinant vaccine containing a single nonameric T-cell epitope [PDF]

, 1991
The regulatory immediate-early (IE) protein pp89 of murine cytomegalovirus induces CD8+ T lymphocytes that protect against lethal murine cytomegalovirus infection.
Ulrich, H. Koszinowski, Koszinowski, Ulrich H., Messerle, Martin, Matthias J. Reddehase, Hansjurgen Volkmer, Reddehase, Matthias J., Del Val, Margarita, Margarita Del Val, Martin Messerle, Volkmer, Hansjürgen, Hans-jurgen Schlicht, Schlicht, Hans-Jürgen   +12 more
core   +1 more source

DENV-Mimetic Polymersome Nanoparticles Bearing Multi-Epitope Lipopeptides Antigen as the Next-Generation Dengue Vaccine

Pharmaceutics, 2022
Dengue remains a severe threat to public health. The safety and efficacy of the licensed dengue vaccine is not clinically satisfactory, which necessitate the need of new approach in designing an effective dengue vaccine without eliciting adverse reaction.
Nur Adilah Abdul Rahman, Abdin Shakirin Mohamad Norpi, Muhammad Luqman Nordin, Mohd Cairul Iqbal Mohd Amin, Abdullah Al-Hadi Ahmad Fuaad, Nor Azila Muhammad Azami, Nirmal Marasini, Fazren Azmi   +7 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Epitope Labeling of Histidine Decarboxylase in Drosophila melanogaster [PDF]

, 2006
Histidine decarboxylase (HDC) plays a critical role in the synthesis of histamine, a central nervous system neurotransmitter used by both vertebrates and invertebrates.
Payne, Stephanie A. N.
core  

Design of a Multi-epitope Peptide Vaccine against SARS-CoV-2 based on Immunoinformatics Data

Journal of Mazandaran University of Medical Sciences, 2020
Background and purpose: In 2019, the world has witnessed the emergence of a virus that caused acute respiratory distress syndrome in human with high mortality rates (approximately 3.7%).
Alireza Habibi, Amin Azizan, Yahya Ehteshaminia, Farhad Jadidi-Niaragh, Ehsan Enderami, Esmaeil Akbari, Saeid Abediankenari, Hadi Hassannia   +7 more
doaj  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

A novel multi-epitope recombined protein for diagnosis of human brucellosis [PDF]

BMC Infectious Diseases, 2016
In epidemic regions of the world, brucellosis is a reemerging zoonosis with minimal mortality but is a serious public hygiene problem. Currently, there are various methods for brucellosis diagnosis, however few of them are available to be used to diagnose, especially for serious cross-reaction with other bacteria.To overcome this disadvantage, we ...
Yin, Dehui, Li, Li, Song, Xiuling, Li, Han, Wang, Juan, Ju, Wen, Qu, Xiaofeng, Song, Dandan, Liu, Yushen, Meng, Xiangjun, Cao, Hongqian, Song, Weiyi, Meng, Rizeng, Liu, Jinhua, Li, Juan, Xu, Kun   +15 more
openaire   +4 more sources

Rapid and simultaneous multiepitope antigen-based detection of Enterococcus by microscale thermophoresis and immunomagnetic separation

Frontiers in Microbiology
BackgroundGenerally, enterococci bacteria cause nosocomial infections and are major indicators of bacterial contamination in marine bathing beach. However, a method for the rapid and simultaneous detection of multiple pathogenic enterococci has not been ...
Yan Liu, Yan Liu, Ziyan Wang, Ziyan Wang, Ze Wang, Ze Wang, Jun Zhou, Jun Zhou, Jiaojiao Han, Jiaojiao Han, Chenyang Lu, Chenyang Lu, Bing Liu, Rongxian Yu, Xiaoling Sun, Zhen Zhang, Zhen Zhang, Rixin Wang, Xiurong Su, Xiurong Su   +19 more
doaj   +1 more source

Whole Yeast Vaccine Displaying ZIKV B and T Cell Epitopes Induces Cellular Immune Responses in the Murine Model

Pharmaceutics, 2023
Improving antigen presentation is crucial for the success of immunization strategies. Yeasts are classically used as biofactories to produce recombinant proteins and are efficient vehicles for antigen delivery, in addition to their adjuvant properties ...
Anna Jéssica Duarte Silva, André Luiz Santos de Jesus, Lígia Rosa Sales Leal, Larissa Silva de Macêdo, Bárbara Rafaela da Silva Barros, Georon Ferreira de Sousa, Simone da Paz Leôncio Alves, Lindomar José Pena, Cristiane Moutinho Lagos de Melo, Antonio Carlos de Freitas   +9 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source