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VaccineDesigner: A Web-Based Tool for Streamlined Multi-Epitope Vaccine Design
BiologyBackground: Multi-epitope vaccines have become the preferred strategy for protection against infectious diseases by integrating multiple MHC-restricted T-cell and B-cell epitopes that elicit both humoral and cellular immune responses against pathogens ...
Dimitrios Trygoniaris +7 more
doaj +2 more sources
Epitope-Based Specific Antibody Modification [PDF]
, 2023 Modified antibodies play essential roles in various fields, such as analysis, diagnosis, and therapy, which require modified antibodies with optimal physical and biological properties.
Saki, Horie +6 more
core +1 more source
Heliyon, 2020 Rotavirus is the most common cause of acute gastroenteritis in infants and children worldwide. The functional correlation of B- and T-cells to long-lasting immunity against rotavirus infection in the literature is limited.
Yengkhom Damayanti Devi +12 more
doaj +1 more source
In silico design of recombinant multi-epitope vaccine against influenza A virus
BMC Bioinformatics, 2022 Background Influenza A virus is one of the leading causes of annual mortality. The emerging of novel escape variants of the influenza A virus is still a considerable challenge in the annual process of vaccine production.
Avisa Maleki +3 more
doaj +1 more source
, 2023 The thermodynamic interactions of three proposed multi-epitope-based vaccines against P. aeruginosa with TLR1, 2, and 4.
Behnoush Khasheii (16748697) +5 more
core +1 more source
Dynamics of virus and immune response in multi-epitope network [PDF]
Journal of Mathematical Biology, 2018 The host immune response can often efficiently suppress a virus infection, which may lead to selection for immune-resistant viral variants within the host. For example, during HIV infection, an array of CTL immune response populations recognize specific epitopes (viral proteins) presented on the surface of infected cells to effectively mediate their ...
Browne, Cameron J., Smith, Hal L.
openaire +3 more sources
Application of In-Silico Reverse Vaccinology for Designing Multi-Epitope Vaccine Against Coronavirus [PDF]
, 2020 In absence of any specific medication or vaccine till now, experimentation has reached new heights. With lockdown imposed in almost every country and huge economic losses the search for a suitable vaccine has still been unsuccessful.
Dr. Shubhangi, Dange, Kumar, Sharp
core +1 more source
Designing of Multi-Epitope Peptide Vaccine Based on Outer Membrane Proteins OmpF, OmpC, and PgtE of Salmonella enterica Typhi [PDF]
Archives of Razi Institute, 2023 Consumption of contaminated water and foods by Salmonella Typhi cause the most common enteric disease known as Typhoid fever in both humans and animals.
Fereshteh Ezzati Ghadi +2 more
doaj +1 more source
Epitope-Based Specific Antibody Modifications
, 2023 Modified antibodies have essential roles in analytic, diagnostic, and therapeutic uses, and thus, these antibodies are required to have optimal physical and biological properties.
Kenji Mishiro (1910746) +6 more
core +1 more source
B-Cell Epitope Discovery: The First Protein Flexibility-Based Algorithm – Zika Virus Conserved Epitope Demonstration [PDF]
, 2020 Antibody-antigen interaction – at antigenic local environments called B-cell epitopes – is a prominent mechanism for neutralization of infection. Effective mimicry, and display, of B-cell epitopes is key to vaccine design.
Peter J., Ortoleva +2 more
core +1 more source