Results 41 to 50 of about 3,636,379 (304)

Design of immunogenic and effective multi-epitope DNA vaccines for melanoma [PDF]

Cancer Immunology, Immunotherapy, 2011
Plasmid DNA vaccination is an attractive way to elicit T cell responses against infectious agents and tumor cells. DNA constructs can be designed to contain multiple T cell epitopes to generate a diverse immune response to incorporate numerous antigens and to reduce limitations due to MHC restriction into a single entity.
Hyun-Il, Cho, Esteban, Celis
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Design of multi-epitope vaccine constructs of SARS-CoV-2.

, 2021
Design of multi-epitope vaccine constructs of SARS-CoV-2.
Vashkar Biswa (11707490), Chen Chongtham (11707487), Anutee Dolley (11707484), Robin Doley (2308216), Chongtham Shyamsunder Singh (11707499), Suvendra Kumar Ray (11707496), Chandrima Doley (11707481), Manabendra Mandal (1802338), Pabitra Nath (3589217), Yengkhom Damayanti Devi (11707472), Arpita Devi (9286923), Siddhartha Shankar Satapathy (11707493), Partha Pratim Borah (11707502), Aditya Kumar (2629198), Nima D. Namsa (11707505), Latonglila Jamir (10843498), Sandeep Das (439300), Sushmita Konwar (11707478), Dikshita Dowerah (9147290), Ramesh Chandra Deka (567929), Himanshu Ballav Goswami (11707475)   +20 more
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Evaluation of immunoprotective effects of PlpE multi-epitope protein incorporated within the aluminum hydroxide-adjuvanted inactivated vaccine against Pasteurella multocida infection in chickens

Poultry Science
Pasteurella multocida (Pm) is a major zoonotic pathogen that causes avian cholera in poultry, leading to significant economic losses. Although inactivated vaccines are commonly used, their immunogenicity is limited, highlighting the need for safer and ...
Xuelian Xiang, Yi Sun, Haili Zhang, Xinrui Wu, Jing Xia, Xinfeng Han, Yong Huang, Min Cui   +7 more
doaj   +1 more source

Protective CD8+ T-cell response against Hantaan virus infection induced by immunization with designed linear multi-epitope peptides in HLA-A2.1/Kb transgenic mice

Virology Journal, 2020
Background An effective vaccine that prevents disease caused by hantaviruses is a global public health priority, but up to now, no vaccine has been approved for worldwide use.
Ying Ma, Kang Tang, Yusi Zhang, Chunmei Zhang, Linfeng Cheng, Fanglin Zhang, Ran Zhuang, Boquan Jin, Yun Zhang   +8 more
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Designing a Multi-Epitope Subunit Vaccine against VP1 Major Coat Protein of JC Polyomavirus

, 2023
The JC polyomavirus virus (JCPyV) affects more than 80% of the human population in their early life stage. It mainly affects immunocompromised individuals where virus replication in oligodendrocytes and astrocytes may lead to fatal progressive multifocal
Pandey, RK, Rajan Kumar Pandey, Bajarang Vasant Kumbhar, Kumbhar, BV, Khandelwal, M, Khokhar, M, Kanse, S, Desai, N, Mehak Khandelwal, Sukhada Kanse, Neetin Desai, Manoj Khokhar   +11 more
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Candidate Multi-Epitope Vaccine against Corona B.1.617 Lineage: In Silico Approach

Life, 2022
Various mutations have accumulated since the first genome sequence of SARS-CoV2 in 2020. Mutants of the virus carrying the D614G and P681R mutations in the spike protein are increasingly becoming dominant all over the world.
Mohamed G. Seadawy, Abdel Rahman N. Zekri, Aya A. Saeed, Emmanuel James San, Amr M. Ageez   +4 more
doaj   +1 more source

Design and validation of a novel multi-epitopes vaccine against hantavirus

Journal of Biomolecular Structure and Dynamics, 2023
Hantavirus is a member of the order Bunyavirales and an emerging global pathogen. Hantavirus infections have affected millions of people globally based on available epidemiological data and research studies. Hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS) are the two main human diseases associated with hantavirus ...
Taghreed N. Almanaa, Ayman Mubarak, Muhammad Sajjad, Asad Ullah, Muhammad Hassan, Yasir Waheed, Muhammad Irfan, Saifullah Khan, Sajjad Ahmad   +8 more
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Heterologous prime-boost-boost immunisation of Chinese cynomolgus macaques using DNA and recombinant poxvirus vectors expressing HIV-1 virus-like particles [PDF]

, 2011
Background: There is renewed interest in the development of poxvirus vector-based HIV vaccines due to the protective effect observed with repeated recombinant canarypox priming with gp120 boosting in the recent Thai placebo-controlled trial.
Bridge, S., Skinner, Michael A., Anson, Donald, Dennis, M., Simon H Bridge, Dowall, S., Blanchard, Tom J., Getty, B., Stewart, James, Dennis, Mike J., Dowall, SD, Donald S Anson, Anson, D., Dennis, MJ, Bridge, Simon H., Dowall, Stuart D., Blanchard, Thomas, Stewart, JP, Blanchard, T., Skinner, M., Stewart, James P., James P Stewart, Mike J Dennis, Getty, B, Michael A Skinner, Bridge, SH, Bridge, Simon, Sharpe, Sally, Sharpe, SA, Skinner, MA, Getty, Brian, Brian Getty, Dennis, Mike, Blanchard, Tom, Sharpe, Sally A., Anson, DS, Sally A Sharpe, Skinner, Michael, Stuart D Dowall, Tom J Blanchard, Blanchard, TJ, Anson, Donald S., Stewart, J., Sharpe, S., Dowall, Stuart   +44 more
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Design of Multi-Epitope Vaccine for Staphylococcus saprophyticus: Pan-Genome and Reverse Vaccinology Approach

, 2022
Staphylococcus saprophyticus is a Gram-positive coccus responsible for the occurrence of cystitis in sexually active, young females. While effective antibiotics against this organism exist, resistant strains are on the rise.
Sarosh, Nida, Bin Emran, Talha, Jawaher A. Abdulhakim, Abdulhakim, Jawaher A., Bibi, Shabana, Sumra Wajid Abbasi, Mohammad Mehedi Hasan, Ghadeer M. Albadrani, Albadrani, Ghadeer M., Saba Ismail, Nehal Ahmed Talaat Nouh, Talha Bin Emran, Ismail, Saba, Asad Ullah, Abbasi, Sumra Wajid, Nida Sarosh, Talaat Nouh, Nehal Ahmed, Maha Yousaf, Mohamed M. Abdel-Daim, Hasan, Mohammad Mehedi, Abdel-Daim, Mohamed M., Yousaf, Maha, Ullah, Asad, Shabana Bibi   +23 more
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Protective multi-epitope candidate vaccine for urinary tract infection

Biotechnology Reports, 2020
Urinary tract infections (UTIs) are induced by exogenous organisms including extraintestinal pathogenic such as Escherichia coli (ExPEC), Proteus mirabilis and Klebsiella pneumonia, which are closely related. These organisms can colonize in the urinary tract and cause UTIs.
Mana Oloomi, Maryam Javadi, Mohammad Reza Asadi Karam, Jamil Kheirvari Khezerloo, Zohreh Haghri, Saeid Bouzari   +5 more
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