Results 1 to 10 of about 562,468 (202)
Is the reverse vaccinology idea becoming exhausted? [PDF]
Frontiers in ImmunologyReverse vaccinology (RV) was originally conceived to leverage genomic information for antigen selection and promised a paradigm change in vaccine design.
Javier Zumárraga +5 more
doaj +5 more sources
Viruses, 2023 mRNA vaccines are a new class of vaccine that can induce potent and specific immune responses against various pathogens. However, the design of mRNA vaccines requires the identification and optimization of suitable antigens, which can be challenging and ...
Maria Karolaynne da Silva +6 more
doaj +4 more sources
NERVE: New Enhanced Reverse Vaccinology Environment [PDF]
BMC Biotechnology, 2006 Background Since a milestone work on Neisseria meningitidis B, Reverse Vaccinology has strongly enhanced the identification of vaccine candidates by replacing several experimental tasks using in silico prediction steps.
Filippini Francesco +2 more
doaj +5 more sources
A reverse vaccinology approach to swine dysentery vaccine development [PDF]
Veterinary Microbiology, 2009 Swine dysentery (SD) is a mucohaemorrhagic colitis of pigs resulting from infection of the large intestine with the anaerobic intestinal spirochaete Brachyspira hyodysenteriae. Whole-cell bacterin vaccines are available to help control SD, but their performance has been inconsistent. This study aimed to use a reverse vaccinology approach to identify B.
Matthew Bellgard +2 more
exaly +7 more sources
Vaccines, 2023 The clinical use of antibiotics has led to the emergence of multidrug-resistant (MDR) bacteria, leading to the current antibiotic resistance crisis. To address this issue, next-generation vaccines are being developed to prevent antimicrobial resistance ...
Kanwal Khalid, Chit Laa Poh
doaj +3 more sources
Editorial: Reverse Vaccinology [PDF]
Frontiers in Immunology, 2019 Richard Moxon +3 more
doaj +3 more sources
Reverse Vaccinology: An Approach for Identifying Leptospiral Vaccine Candidates [PDF]
International Journal of Molecular Sciences, 2017 Leptospirosis is a major public health problem with an incidence of over one million human cases each year. It is a globally distributed, zoonotic disease and is associated with significant economic losses in farm animals. Leptospirosis is caused by pathogenic Leptospira spp. that can infect a wide range of domestic and wild animals.
Thaïs Oliveira +2 more
exaly +3 more sources
COVID-19 Coronavirus Vaccine Design Using Reverse Vaccinology and Machine Learning
Frontiers in Immunology, 2020 To ultimately combat the emerging COVID-19 pandemic, it is desired to develop an effective and safe vaccine against this highly contagious disease caused by the SARS-CoV-2 coronavirus. Our literature and clinical trial survey showed that the whole virus,
Edison Ong +4 more
doaj +3 more sources
Frontiers in Microbiology, 2023 Many pathogens cause reproductive failure in sows suffering a broad spectrum of sequelae, including abortions, stillbirth, mummification, embryonic death, and infertility.
Yuan Chen +12 more
doaj +1 more source
Current knowledge on epidemiology and evolution of novel porcine circovirus 4
Veterinary Research, 2022 Porcine circovirus type 4 (PCV4) is a newly emerging virus, with both PCV4 genomic DNA and specific antibodies detected in swine herds in several provinces in China and South Korea.
Dongliang Wang +4 more
doaj +1 more source