Results 31 to 40 of about 562,468 (202)
Data, 2023 Reverse vaccinology (RV) is a computer-aided approach for vaccine development that identifies a subset of pathogen proteins as protective antigens (PAgs) or potential vaccine candidates. Machine learning (ML)-based RV is promising, but requires a dataset
Zakia Salod, Ozayr Mahomed
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Reverse Vaccinology in Plasmodium falciparum 3D7 [PDF]
Journal of Immunological Techniques in Infectious Diseases, 2016 A timely immunization can be effective against certain diseases and can save thousands of lives. However, for some diseases it has been difficult, so far, to develop an efficient vaccine. Malaria, a tropical disease caused by a parasite of the genus Plasmodium, is one example. Bioinformatics has opened the way to new lines of experimental investigation
Isea, Raul +2 more
openaire +2 more sources
Advanced vaccinology education: Landscaping its growth and global footprint
, 2020 International audienceIn preparation for the first Global Vaccinology Training workshop in 2018, a survey of 27 advanced vaccinology courses was conducted to provide a landscape of the vaccinology education around the world.
Lambert, Paul-Henri +5 more
core +1 more source
Pathogen proteins eliciting antibodies do not share epitopes with host proteins: a bioinformatics approach. [PDF]
PLoS ONE, 2007 The best way to prevent diseases caused by pathogens is by the use of vaccines. The advent of genomics enables genome-wide searches of new vaccine candidates, called reverse vaccinology.
Isaac Amela, Juan Cedano, Enrique Querol
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Non-muscle Myosin II: Role in Microbial Infection and Its Potential as a Therapeutic Target
Frontiers in Microbiology, 2019 Currently, the major measures of preventing and controlling microbial infection are vaccinations and drugs. However, the appearance of drug resistance microbial mounts is main obstacle in current anti-microbial therapy.
Lei Tan +5 more
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BMC Bioinformatics, 2019 Background A revolutionary diversion from classical vaccinology to reverse vaccinology approach has been observed in the last decade. The ever-increasing genomic and proteomic data has greatly facilitated the vaccine designing and development process ...
Kanwal Naz +6 more
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Systematic Reviews, 2022 Background Vaccination is essential for the prevention of infectious diseases and has helped to reduce disease-related mortality, such as pneumonia. However, traditional vaccine development is time-consuming and risky.
Zakia Salod, Ozayr Mahomed
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Relationship of Noncoding RNA and Swine Viruses
Intervirology, 2022 Background: Swine viruses are well known as a threat to the pig industry. Many signaling pathways and a number of proteins were discovered to participate in the immune responses to swine viruses.
Manxin Fang, Wei Hu, Zhibang Deng
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Post-Genomics and Vaccine Improvement for Leishmania
Frontiers in Microbiology, 2016 Leishmaniasis is a parasitic disease that primarily affects Asia, Africa, South America and the Mediterranean basin. Despite extensive efforts to develop an effective prophylactic vaccine, no promising vaccine is available yet.
Negar eSeyed +2 more
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Fight fire with fire: the need for a vaccine based on intrinsic disorder and structural flexibility
Exploration of Immunology, 2022 The absence of advancement in finding efficient vaccines for several human viruses, such as hepatitis C virus (HCV), human immunodeficiency virus type 1 (HIV-1), and herpes simplex viruses (HSVs) despite 30, 40, and even 60 years of research ...
Vladimir N. Uversky
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