Results 41 to 50 of about 562,468 (202)

Reverse vaccinology on the cusp [PDF]

Nature Reviews Drug Discovery, 2012
An upcoming decision for Novartis's Bexsero — the first vaccine against meningococcus B — could substantiate reverse vaccinology.
openaire   +1 more source

A novel nanoparticle vaccine, based on S1-CTD, elicits robust protective immune responses against porcine deltacoronavirus

Journal of Virology
Porcine deltacoronavirus (PDCoV), an emerging swine pathogen causing severe enteric disease in piglets, poses cross-species transmission risks, including humans.
Qing He, Yawen Zou, Beilei Yu, Qian Yuan, Chenguang Meng, Chenxuan Du, Zhiyong Wang, Jiahao Lian, Shile Luo, Siyu Cao, Wenbing Yang, Dantong Li, Hongyu Lei, Yang Zhan, Wenfeng Zhou, Yi Yang, Naidong Wang   +16 more
doaj   +1 more source

Probing the Rhipicephalus bursa Sialomes in Potential Anti-Tick Vaccine Candidates: A Reverse Vaccinology Approach

Biomedicines, 2021
In the wake of the ‘omics’ explosion of data, reverse vaccinology approaches are being applied more readily as an alternative for the discovery of candidates for next generation diagnostics and vaccines.
Joana Couto, Gonçalo Seixas, Christian Stutzer, Nicholas A. Olivier, Christine Maritz-Olivier, Sandra Antunes, Ana Domingos   +6 more
doaj   +1 more source

Reverse Vaccinology: Developing Vaccines in the Era of Genomics [PDF]

Immunity, 2010
The sequence of microbial genomes made all potential antigens of each pathogen available for vaccine development. This increased by orders of magnitude potential vaccine targets in bacteria, parasites, and large viruses and revealed virtually all their CD4(+) and CD8(+) T cell epitopes.
Sette, Alessandro, Rappuoli, Rino
openaire   +2 more sources

Challenges and Strategies for Developing Recombinant Vaccines against Leptospirosis: Role of Expression Platforms and Adjuvants in Achieving Protective Efficacy

Pathogens, 2023
The first leptospiral recombinant vaccine was developed in the late 1990s. Since then, progress in the fields of reverse vaccinology (RV) and structural vaccinology (SV) has significantly improved the identification of novel surface-exposed and conserved
Natasha Rodrigues de Oliveira, Francisco Denis Souza Santos, Vitória Adrielly Catschor dos Santos, Mara Andrade Colares Maia, Thaís Larré Oliveira, Odir Antônio Dellagostin   +5 more
doaj   +1 more source

Generation of Nasal Cell‐Derived Human Alveolar Organoids and Organoid‐Macrophage Assembloids for in Vitro Lung Modeling

Advanced Science, EarlyView.
This study demonstrates the generation of human alveolar organoids from nasal cells, which, when co‐cultured with monocyte‐derived macrophages, promotes maturation of both components and forms alveolar assembloids resembling native alveoli. These alveolar organoids and assembloids offer accessible, physiologically relevant in vitro systems for ...
Man Chun Chiu, Shuxin Zhang, Cun Li, Yifei Yu, Zhixin Wan, Jingjing Huang, Wei Xue, Ying Zhou, Xiaoxin Zhu, Qiaoshuai Lan, Jiali Wu, Zijun Zhao, Yuhong Liu, Xinjie Meng, Lin Huang, Hin Chu, Honglin Chen, Kelvin Kai‐Wang To, Kwok Yung Yuen, Jie Zhou   +19 more
wiley   +1 more source

Annexin A2 facilitates porcine circovirus type 2 infection by mediating viral attachment to host cells and interacting with the capsid protein

Veterinary Research
Porcine circovirus type 2 (PCV2) causes substantial economic losses globally. Although glycosaminoglycans (GAGs) have been identified as the general cell receptors responsible for PCV2 binding and subsequent cell infection, other critical protein(s) may ...
Yifan Jiang, Xinnuo Lei, Weijiao Liu, Siyu Cao, Qing He, Xiaohong Xie, Yang Zhan, Lei Tan, Jinhui Mai, Lingchen Yang, Aibing Wang, Yi Yang, Naidong Wang   +12 more
doaj   +1 more source

Immunoinformatics‐Based Design of a Multi‐Epitope Vaccine Targeting a Conserved Copper–Associated Protein in Neisseria gonorrhoeae

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Neisseria gonorrhoeae poses an urgent public health challenge due to rapidly increasing antimicrobial resistance and the absence of an effective vaccine. Targeting conserved bacterial pathways involved in essential physiological processes may provide new opportunities for vaccine antigen discovery.
Sinethemba H. Yakobi, Uchechukwu U. Nwodo   +1 more
wiley   +1 more source

Reverse Vaccinology: Basics and Applications

Journal of Vaccines & Vaccination, 2013
Vaccinomics is a new branch of bioinformatics that deals with designing a candidate vaccine against a pathogen that can be used for production of the vaccine in less time as that of conventional vaccinology. Reverse vaccinology is a part of vaccinomics which starts with the genome of pathogen and is used for the predicting the epitope.
Amol M Kanampalliwar Rajkumar Soni, Amandeep Girdhar Archana Tiwari   +1 more
openaire   +1 more source

Targeting Amastigote and Trypomastigote Phases: Multi‐Epitope Vaccine Strategy Against Trypanosoma cruzi

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Effective vaccines against Trypanosoma cruzi, the causative agent of Chagas disease, are urgently needed. Here, we report the design and in silico validation of a novel multiepitope vaccine construct targeting the key surface proteins ASP‐2 and gp82. Using a comprehensive immunoinformatics pipeline, we identified and selected 38 potent T‐cell (
Maria Karolaynne da Silva, Caio Patrício de Souza Sena, Davi Serradella Vieira, Magdi E. A. Zaki, Leow Chiuan Yee, Shahina Akter, Umberto Laino Fulco, Jonas Ivan Nobre Oliveira, João Firmino Rodrigues‐Neto   +8 more
wiley   +1 more source