Results 61 to 70 of about 562,468 (202)

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, Volume 16, Issue 9, Page 1801-1812, September 2026.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Vaxign: a web-based vaccine target design program for reverse vaccinology [PDF]

, 2009
In the post-genomic era, strategies of vaccine development have progressed dramatically from traditional Pasteur's principles of isolating, inactivating and injecting the causative agent of an infectious disease, to reverse vaccinology that starts from ...
Xiang, Zuoshuang, He, Yongqun
core   +1 more source

A reverse vaccinology approach identifies putative vaccination targets in the zoonotic nematode Ascaris [PDF]

, 2022
Ascariasis is the most prevalent helminthic disease affecting both humans and pigs and is caused by the roundworms Ascaris lumbricoides and Ascaris suum.
Lawton, SP; id_orcid, Betson, Martha, van Vliet, Arnoud H. M., Evangelista, Francisco, Lawton, Scott P., van Vliet, Arnoud, Evangelista, Francisco M. D.   +6 more
core   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, Volume 16, Issue 9, Page 1813-1824, September 2026.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

From Identification to Enzymatic Activity Profiling: Comprehensive Characterization of BloCAβ, a Probiotic β‐Carbonic Anhydrase From Bifidobacterium longum

Archiv der Pharmazie, Volume 359, Issue 9, September 2026.
Production and biochemical characterization of a new β‐carbonic anhydrase from the probiotic Bifidobacterium longum, one of the main players of human gut microbiota. ABSTRACT The microbiota comprises communities of microorganisms that establish complex relationships with the host and play key roles in physiology, metabolism, and immunity.
Simone Giovannuzzi, Andrea Ammara, Simone Carradori, Viviana De Luca, Marialucia Gallorini, Damiano Iacovozzi, Amelia Cataldi, Ilaria D'Agostino, Davide Moi, Valentina Onnis, Claudiu T. Supuran, Clemente Capasso   +11 more
wiley   +1 more source

Use of Dried Blood Spots for Identifying Hepatitis E Infections in an Outbreak Setting

Journal of Medical Virology, Volume 98, Issue 9, September 2026.
ABSTRACT Accurate and accessible diagnostics for hepatitis E virus (HEV) are essential for outbreak preparedness and surveillance, particularly in low‐resource settings. Dried blood spots (DBS) are a scalable alternative to serum, but their diagnostic performance for HEV remains poorly characterised.
Catia Alvarez, Robin Nesbitt, Kinya Vincent Asilaza, Pascale Sattonnet‐Roche, Joseph Wamala, Shimul Das, Melat Haile, Monica Rull, Etienne Gignoux, Manuel Albela, John Rumunu, Isabella Eckerle, Iza Ciglenecki, Andrew S. Azman, Benjamin Meyer   +14 more
wiley   +1 more source

Report of the 2nd workshop of the International Collaboration on advanced vaccinology training

, 2022
: At a workshop on 22-24 March 2022, leaders of 33 advanced vaccinology courses were invited to meet with partners to further the aims of the International Collaboration on Advanced Vaccinology Training (ICAVT) initiated in 2018 to assist courses in ...
Lambert, Paul-Henri, Duclos, Philippe, Dochez, Carine, Wharton, Melinda, Steffen, Christoph A., Nohynek, Hanna, MacDonald, Noni E., Thacker, Naveen   +7 more
core  

Reverse vaccinology as a platform for antigen discovery: towards the development of an effective staphylococcal vaccine

Microbiology Independent Research Journal
BACKGROUND: Gram-positive cocci, particularly Staphylococcus aureus and Staphylococcus epidermidis , are common components of the human microbiota but can act as opportunistic pathogens, causing a wide range of infections.
Khaled Jasem
doaj   +1 more source

Human Cytomegalovirus Genetic Diversity, Clinical Relevance, and Emerging Insights

Reviews in Medical Virology, Volume 36, Issue 5, September 2026.
ABSTRACT Human cytomegalovirus (HCMV) is a globally prevalent virus that poses a significant public health concern, especially for newborns and immunocompromised patients, causing a wide range of infections. Clinical outcomes associated with HCMV infection include congenital disease, graft rejection in transplant recipients, and life‐threatening ...
Hajar Y. AlQahtani, Fadilah Sfouq Aleanizy, Fulwah Yahya Alqahtani   +2 more
wiley   +1 more source

New Approaches to Vaccinology Made Possible by Advances in Next Generation Sequencing, Bioinformatics and Protein Modeling

, 2021
Vaccines can be powerful tools, but for some diseases, safe and effective vaccines have been elusive. New developments in nucleic acid sequencing, bioinformatics, and protein modeling are facilitating the discovery of previously unknown antigens through ...
Cypriana Swiderski, Amelia R. Woolums
core   +1 more source