Results 21 to 30 of about 562,468 (202)

Immunoinformatic Analysis of T- and B-Cell Epitopes for SARS-CoV-2 Vaccine Design

Vaccines, 2020
Currently, there is limited knowledge about the immunological profiles of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). We used computer-based immunoinformatic analysis and the newly resolved 3-dimensional (3D) structures of the SARS-CoV ...
Dongliang Wang, Jinhui Mai, Wenfeng Zhou, Wanting Yu, Yang Zhan, Naidong Wang, Neal D. Epstein, Yi Yang   +7 more
doaj   +1 more source

Mapping Potential Vaccine Candidates Predicted by VaxiJen for Different Viral Pathogens between 2017–2021—A Scoping Review

Vaccines, 2022
Reverse vaccinology (RV) is a promising alternative to traditional vaccinology. RV focuses on in silico methods to identify antigens or potential vaccine candidates (PVCs) from a pathogen’s proteome.
Zakia Salod, Ozayr Mahomed
doaj   +1 more source

Review on Approaches of A Reverse Vaccinology for Dangerous Pathogens of Animal [PDF]

, 2023
The traditional method of vaccine development includes pathogen culture in the laboratory, but this is not possible in the case of highly infectious pathogens that are hazardous to culture in the laboratory.Reverse vaccinology is regarded as a low-cost ...
Mulatu, Henok
core   +1 more source

Reverse vaccinology and subtractive genomics approaches for identifying common therapeutics against Mycobacterium leprae and Mycobacterium lepromatosis [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2021
Background Mycobacterium leprae and Mycobacterium lepromatosis are gram-positive bacterial pathogens and the causative agents of leprosy in humans across the world.
Arun Kumar Jaiswal, Sandeep Tiwari, Syed Babar Jamal, Letícia de Castro Oliveira, Helioswilton Sales-Campos, Leonardo Eurípedes Andrade-Silva, Carlo Jose Freire Oliveira, Preetam Ghosh, Debmalya Barh, Vasco Azevedo, Siomar C. Soares, Virmondes Rodrigues Junior, Marcos Vinicius da Silva   +12 more
doaj   +1 more source

Development and application of a baculovirus-expressed capsid protein-based indirect ELISA for detection of porcine circovirus 3 IgG antibodies

BMC Veterinary Research, 2019
Background Porcine circovirus type 3 (PCV3), recently widely isolated from pigs with various clinical conditions, is likely globally epidemic. However, development of serological diagnosis for PCV3 in pigs is ongoing. Our objectives were to: 1) establish
Sujiao Zhang, Dongliang Wang, Yifan Jiang, Zhoumian Li, Yawen Zou, Meng Li, Haoyang Yu, Kun Huang, Yi Yang, Naidong Wang   +9 more
doaj   +1 more source

Beyond the state of the art of reverse vaccinology: predicting vaccine efficacy with the universal immune system simulator for influenza

BMC Bioinformatics, 2023
When it was first introduced in 2000, reverse vaccinology was defined as an in silico approach that begins with the pathogen's genomic sequence. It concludes with a list of potential proteins with a possible, but not necessarily, list of peptide ...
Giulia Russo, Elena Crispino, Avisa Maleki, Valentina Di Salvatore, Filippo Stanco, Francesco Pappalardo   +5 more
doaj   +1 more source

Rational Vaccine Design by Reverse & Structural Vaccinology and Ontology [PDF]

, 2021
Vaccination is one of the most successful public health interventions in modern medicine. However, it is still challenging to develop effective vaccines against many infectious diseases such as tuberculosis, HIV, and malaria.
Ong, Edison
core   +1 more source

Structure-Based Design of Porcine Circovirus Type 2 Chimeric VLPs (cVLPs) Displays Foreign Peptides on the Capsid Surface

Frontiers in Cellular and Infection Microbiology, 2018
Although porcine circovirus-like particles can function as a vector to carry foreign peptides into host cells, displaying foreign peptides on the surface of virus-like particles (VLPs) remains challenging.
Dongliang Wang, Sujiao Zhang, Yawen Zou, Wanting Yu, Yifan Jiang, Yang Zhan, Naidong Wang, Yanpeng Dong, Yi Yang   +8 more
doaj   +1 more source

Reverse vaccinology approach for the identifications of potential vaccine candidates against Salmonella

International Journal of Medical Microbiology, 2021
Salmonella is a leading cause of foodborne pathogen which causes intestinal and systemic diseases across the world. Vaccination is the most effective protection against Salmonella, but the identification and design of an effective broad-spectrum vaccine ...
Jie Li, Jingxuan Qiu, Zhiqiang Huang, Tao Liu, Jing Pan, Qi Zhang, Qing Liu   +6 more
doaj   +1 more source

Computational vaccinology and the ICoVax 2012 workshop [PDF]

, 2015
Computational vaccinology or vaccine informatics is an interdisciplinary field that addresses scientific and clinical questions in vaccinology using computational and informatics approaches.
Cao, Zhiwei, Brusic, Vladimir, De Groot, Anne S, Schönbach, Christian, Petrovsky, Nikolai, He, Yongqun   +5 more
core   +3 more sources