Results 21 to 30 of about 3,636,379 (304)

Designing a novel in-silico multi-epitope vaccine against penicillin-binding protein 2A in Staphylococcus aureus

Informatics in Medicine Unlocked, 2022
Research has shown the implication of Penicillin-Binding Protein 2A (PBP2A) as a critical factor in Methicillin-Resistant Staphylococcus aureus (MRSA) as it confers resistance to β‐lactam antibiotics on S.
Simeon Kayowa Olatunde, Elijah Kolawole Oladipo, Joshua Babatunde Owolabi   +2 more
doaj   +1 more source

RTS,S/AS02A malaria vaccine does not induce parasite CSP T cell epitope selection and reduces multiplicity of infection. [PDF]

, 2006
OBJECTIVE: The candidate malaria vaccine RTS,S/AS02A is a recombinant protein containing part of the circumsporozoite protein (CSP) sequence of Plasmodium falciparum, linked to the hepatitis B surface antigen and formulated in the proprietary adjuvant ...
Dobaño, Carlota, 1969-, Sacarlal, Jahit, Conway, David J, Quelhas, Diana, Conway David J, Thompson Ricardo, Sutherland Colin J, Conway, David J., Alonso Pedro L, Quelhas Diana, Ballou W. Ripley, Aponte, John J., Cohen Joe, Dobaño, Carlota, Sutherland, Colin J, Lievens Marc, Dobaño Carlota, Leach, Amanda, Greenwood, Brian, Aponte John J, Alonso, Pedro, Milman Jessica, Cohen, Joe, Enosse, Sonia, Sacarlal Jahit, Greenwood Brian, Aponte, John J, Dubovsky, Filip, Sutherland, Colin J., Ballou, W Ripley, Ballou, W. Ripley, Enosse Sonia, Lievens, Marc, Alonso, Pedro L, Leach Amanda, Dubovsky Filip, Milman, Jessica, Thompson, Ricardo   +37 more
core   +1 more source

Immunoinformatics-Aided Analysis of RSV Fusion and Attachment Glycoproteins to Design a Potent Multi-Epitope Vaccine

, 2022
Respiratory syncytial virus (RSV) usually causes respiratory tract infections of upper airways in infants and young children. Despite recent medical advances, no approved vaccine is available to control RSV infections.
Shahkaar Aziz, Aziz, Shahkaar, Waheed, Yasir, Yasir Waheed, Hamza Arshad Dar, Fahad Nasser Almajhdi, Dar, Hamza Arshad, Almajhdi, Fahad Nasser   +7 more
core   +1 more source

In silico Design of a Crimean-Congo Hemorrhagic Fever Virus Glycoprotein Multi-Epitope Antigen for Vaccine Development

Zoonoses, 2022
No licensed vaccine is available to prevent the severe tick-borne disease Crimean-Congo hemorrhagic fever (CCHF), caused by the CCHF virus (CCHFV). This study sought to show that a combination of computational methods and data from published literature ...
Megan C. Mears, Dennis A. Bente
doaj   +1 more source

Protection against H1N1 influenza challenge by a DNA vaccine expressing H3/H1 subtype hemagglutinin combined with MHC class II-restricted epitopes

Virology Journal, 2010
Background Multiple subtypes of avian influenza viruses have crossed the species barrier to infect humans and have the potential to cause a pandemic. Therefore, new influenza vaccines to prevent the co-existence of multiple subtypes within a host and ...
Tian Mingyao, Zhang Dan, Lu Huijun, Tan Lei, Hu Bo, Wang Zhuoyue, Jin Ningyi   +6 more
doaj   +1 more source

A DNA vaccine construct incorporating intercellular trafficking and intracellular targeting motifs effectively primes and induces memory B and T cell responses in outbred animals [PDF]

, 2007
We developed a vaccine construct in which a BVP22 domain and an invariant-chain major histocompatibility complex class II-targeting motif capable of enhancing dendritic cell antigen uptake and presentation were fused to a sequence encoding a B- and T ...
Palmer, Guy H, Zhuang, Yan, Mwangi, W, Howard, CJ, Aida, Yoko, Hunter, Beverly J, Splitter, Gary A, Brown, WC, Palmer, GH, Hunter, BJ, Aida, Y, Davies, Christopher J, Brown, Wendy C, Davies, CJ, Mwangi, Waithaka, Splitter, GA, Zhuang, Y, Hope, Jayne; id_orcid, Howard, Chris J, Hope, Jayne C   +19 more
core   +1 more source

Employing an immunoinformatics approach revealed potent multi-epitope based subunit vaccine for lymphocytic choriomeningitis virus

Journal of Infection and Public Health, 2023
Background: Lymphocytic choriomeningitis virus (LCMV) infects many individuals worldwide and causes severe infection in the immunosuppressant recipient, spontaneous abortion, and congenital disabilities in infants.
Muhammad Waqas, Shahkaar Aziz, Aiman Bushra, Sobia Ahsan Halim, Amjad Ali, Saeed Ullah, Asaad Khalid, Ashraf N. Abdalla, Ajmal Khan, Ahmed Al-Harrasi   +9 more
doaj   +1 more source

Plasmodium falciparum merozoite surface protein 2: epitope mapping and fine specificity of human antibody response against non-polymorphic domains [PDF]

, 2014
Two long synthetic peptides representing the dimorphic and constant C-terminal domains of the two allelic families of Plasmodium falciparum merozoite surface proteins 2 are considered promising malaria vaccine candidates.
Kajava, Andrey V., Diakité, Mahamadou, Felger, Ingrid, Servis, Catherine, Corradin, Giampietro, D’Alessandro, Alba, Moret, Remy, Balam, Saidou, Nebie, Issa, Kajava, Andrey V, Spertini, François, Olugbile, Sope, Smith, Thomas, D'Alessandro, Alba, Frank, Geraldine, Tanner, Marcel   +15 more
core   +1 more source

Immunoinformatics study of CD40 ligand-targeting vaccine constructs: a novel immunotherapeutic approach [PDF]

Osong Public Health and Research Perspectives
Objectives Incorporating CD40 ligand (CD40L) into vaccine strategies has shown considerable potential for enhancing immune responses. In this study, we designed and formulated a CD40L-based multi-epitope vaccine construct using immunoinformatics ...
Seyed Amir Sadeghi, Mahroo Mohamadi, Hadi Bamehr, Fatemeh Heidarnejad, Azam Bolhassani   +4 more
doaj   +1 more source

The physicochemical properties of a multi-epitope vaccine.

, 2023
The physicochemical properties of a multi-epitope vaccine.
Shahin Nazarian (9192158), Sajjad Ahmad (768814), Hamidreza Pazoki-Toroudi (10879906), Mahdi Ghatreh Samani (15852860), Elham Raeisi (15852857), Samira Sanami (13192454), Muhammad Tahir ul Qamar (9269536), Shahram Tahmasebian (14233182), Maryam Fazeli (3171162)   +8 more
core   +1 more source